| Identification | More | [Name]
1-N-Boc-Aminocyclopentanecarboxylic acid | [CAS]
35264-09-6 | [Synonyms]
1-BOC-AMINO-CYCLOPENTANE-1-CARBOXYLIC ACID
1-(BOC-AMINO)CYCLOPENTANECARBOXYLIC ACID
1-N-BOC-AMINOCYCLOPENTANECARBOXYLIC ACID
1-TERT-BUTOXYCARBONYLAMINO-CYCLOPENTANECARBOXYLIC ACID
BOC-1-AMINO-1-CYCLOPENTANECARBOXYLIC ACID
BOC-1-AMINOCYCLOPENTANE-1-CARBOXYLIC ACID
BOC-1-AMINOCYCLOPENTANECARBOXYLIC ACID
BOC-CLE-OH
BOC-CYCLOLEUCINE
BOC-NH(1)CPNE-OH
N-ALPHA-T-BOC-1-AMINOCYCLOPENTANE CARBOXYLIC ACID
N-ALPHA-T-BUTOXYCARBONYL-1-AMINO-CYCLOPENTANECARBOXYLIC ACID
N-ALPHA-T-BUTOXYCARBONYL-CYCLOLEUCINE
N-BOC-CYCLOLEUCINE
N-TERT-BUTOXYCARBONYL-1-AMINOCYCLOPENTANECARBOXYLIC ACID
Boc-1-aminocyclopentane-1-carboxy acid
1-TERT-BUTYLOXYCARBONYLAMINO-CYCLOPENTANE-1-CARBOXYLIC ACID | [EINECS(EC#)]
-0 | [Molecular Formula]
C11H19NO4 | [MDL Number]
MFCD01076126 | [Molecular Weight]
229.27 | [MOL File]
35264-09-6.mol |
| Chemical Properties | Back Directory | [Appearance]
white to off-white crystalline powder | [Melting point ]
130-135 °C | [Boiling point ]
376.6±21.0 °C(Predicted) | [density ]
1.15±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
Crystalline Powder | [pka]
4.14±0.20(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble in hot water | [BRN ]
2734412 | [CAS DataBase Reference]
35264-09-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [HazardClass ]
IRRITANT | [HS Code ]
29242990 |
| Hazard Information | Back Directory | [Chemical Properties]
white to off-white crystalline powder | [Uses]
Boc-Cycloleucine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | [Synthesis]
Cycloleucine (1.0 g, 7.74 mmol), triethylamine (Et3N, 5.4 mL, 38.7 mmol), 1 M aqueous NaOH (7.74 mL, 7.74 mmol) and acetonitrile (CH3CN, 10 mL) were added to a 250 mL round-bottom flask. The resulting clarified solution was cooled to 0 °C, followed by the slow addition of di-tert-butyl dicarbonate ((Boc)2O). The reaction mixture was gradually warmed to room temperature and stirred continuously for 4 h. A white precipitate was generated during the reaction. After completion of the reaction, the mixture was concentrated and the residue was dissolved in a solvent mixture of ethyl acetate (EtOAc) and water (1:1, 100 mL). The organic phase was separated and the aqueous phase was acidified with 10% HCl and then extracted three times with EtOAc. All organic phases were combined, washed with water and saturated saline in turn, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated to give 1-((tert-butoxycarbonyl)amino)cyclopentanecarboxylic acid as a white solid (1.29 g, 73% yield). | [References]
[1] Chemistry - A European Journal, 2011, vol. 17, # 19, p. 5256 - 5260
[2] Tetrahedron Letters, 1996, vol. 37, # 20, p. 3441 - 3444
[3] Organic Process Research and Development, 1998, vol. 2, # 4, p. 238 - 244
[4] Patent: WO2004/22534, 2004, A1. Location in patent: Page 39
[5] Patent: WO2017/21922, 2017, A1. Location in patent: Page/Page column 29 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Shanghai Ennopharm Co., Ltd.
|
| Telephone: |
+86 (21) 6435-5022 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList13640/0_EN.htm |
| Company Name: |
Aemon Chemical
|
| Telephone: |
0086-755-86198205 |
| Website: |
www.aemonchem.com |
|