| Identification | More | [Name]
Meclofenoxate hydrochloride | [CAS]
3685-84-5 | [Synonyms]
2-(DIMETHYLAMINO)ETHYL 4-CHLOROPHENOXYACETATE HYDROCHLORIDE
[4-CHLOROPHENOXY] ACETIC ACID 2-[DIMETHYLAMINO] ETHYL ESTER HYDROCHLORIDE
CENTROPHENOXIN
CENTROPHENOXINE
CENTROPHENOXINE HYDROCHLORIDE
MECLOFENOXATE
MECLOFENOXATE HCL
MECLOFENOXATE HYDROCHLORIDE
MECLOFENOXAT HYDROCHLORIDE
(p-chlorophenoxy)aceticacid2-(dimethylamino)ethylesterhydrochloride
235anphydrochloride
acefen
aceticacid,(4-chlorophenoxy)-,2-(dimethylamino)ethylester,hydrochloride
aceticacid,(p-chlorophenoxy)-,2-dimethylaminoethylester,hydrochloride
amipolen
brenal
cellative
centrofenoxin
cerutil
chlorowodorkicentrofenoksyna | [EINECS(EC#)]
222-975-3 | [Molecular Formula]
C12H17Cl2NO3 | [MDL Number]
MFCD00012533 | [Molecular Weight]
294.17 | [MOL File]
3685-84-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
133-135°C | [density ]
1.3255 (rough estimate) | [refractive index ]
1.6140 (estimate) | [storage temp. ]
−20°C | [solubility ]
DMSO (Sparingly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Merck ]
13,5803 | [InChI]
InChI=1S/C12H16ClNO3.ClH/c1-14(2)7-8-16-12(15)9-17-11-5-3-10(13)4-6-11;/h3-6H,7-9H2,1-2H3;1H | [InChIKey]
FIVHOHCAXWQPGC-UHFFFAOYSA-N | [SMILES]
C(OCCN(C)C)(=O)COC1=CC=C(Cl)C=C1.[H]Cl | [CAS DataBase Reference]
3685-84-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302 | [Precautionary statements ]
P264-P270-P301+P312a-P330-P501a | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RTECS ]
AG0440000 | [Toxicity]
LD50 in mice (mg/kg): 330 i.v.; 1750 orally; 845 i.p. (Rumpf, Thuillier) |
| Questions And Answer | Back Directory | [Pharmacological action]
Meclofenoxate hydrochloride(MecloCl) [CAS,NO:51-68-3], an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA), has been shown to improve memory, have a mentally stimulating effect, and improve general cognition.
Meclofenoxate hydrochloride is a psychostimulant in the nootropic agent group available in capsule and tablet formulations approved for traumatic cataphora, alcoholic poisoning, anoxia neonatorum, and children's enuresis in China. Although these 2 generic formulations are marketed in China, information regarding their pharmacokinetics and bioequivalence in humans has not been published. Meclofenoxate hydrochloride appears to increase the consolidation of new information into long-term memory. Meclofenoxate does not affect other aspects of remembering. Meclofenoxate is found that significantly more of the subjects receiving meclofenoxate reportes an increased level of mental alertness.
| [Uses]
The applications of is Meclofenoxate hydrochloride:
- Memory decline through aging
- Dementia and Alzheimer’s (clinically)
- Brain damage or injuries
- Alcohol or drug abuse symptoms and effects
- Promote the metabolism of brain
|
| Hazard Information | Back Directory | [Description]
Meclofenoxate hydrochloride is a cholinergic nootropic used as a dietary supplement and drug in the treatment of symptoms of senile dementia and Alzheimer's disease.
| [Chemical Properties]
White Solid | [Mechanism of action]
Meclofenoxate hydrochloride is a cholinergic drug that has been used to treat bowel diseases. It inhibits the enzyme acetylcholinesterase, which breaks down acetylcholine in the body and thus increases the amount of acetylcholine available to stimulate muscle contractions. Meclofenoxate hydrochloride also affects the production of other enzymes, such as those involved in energy metabolism.
| [Side effects]
Possible side effects of meclofenoxate include insomnia, dizziness, restlessness, muscle tremors, depression, nausea, muscle tension, and headache, which are generally rare; these side effects may be associated with overdose of the medication and may indicate the need for a reduction in the dosage of the medication. | [Safety Profile]
Poison by intravenous route.Moderately toxic by ingestion and intraperitoneal routes.When heated to decomposition it emits very toxic fumes ofCl??, NOx, and HCl. |
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| Company Name: |
NCE Biomedical Co.,Ltd.
|
| Telephone: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15748/0_EN.htm |
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