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108-24-7 Structure

108-24-7 Structure

Acetic anhydride


AKOS BBS-00004312
Acetyl acetate
Acetyl anhydride
Acetyl ether
Anhydrid kyseliny octove
Anhydride acetique

[Molecular Formula]

[MDL Number]

[Molecular Weight]

[MOL File]

Chemical PropertiesBack Directory

Acetic anhydride is a colourless liquid and appreciably soluble in water. It is of ethanoic acid smell. Acetic acid anhydride is flammable, moisture sensitive, and incompatible with strong oxidising agents, water, strong bases, alcohols, metals, reducing agents, amines, ammonia, nitrates, nitric acid, permanganates, phenols, sodium hydroxide, hydrogen peroxide, chromium trioxide, potassium hydroxide, perchloric acid, and ethanol. Acetic anhydride is mainly used for the acetylation of cellulose to cellulose acetate for photographic film and other applications. Upon burning, acetic anhydride decomposes and produces toxic gases and toxic fumes including acetic acid fumes. It attacks many metals with or without the presence of water.

Acetic anhydride is a combustible, colorless, strongly refractive, liquid which has a strongly irritating odor.

Colorless liquid
[mp ]

-73.1 °C
[bp ]

140 °C
[density ]

[vapor density ]

3.5 (vs air)
[vapor pressure ]

10 mm Hg ( 36 °C)
[refractive index ]

n20/D 1.390(lit.)
[Fp ]

130 °F
[storage temp. ]

Store at RT.

Stability Flammable. Incompatible with strong oxidizing agents, water, strong bases, alcohols.
[Water Solubility ]


Acetic anhydride is an important solvent and acetylation agent. It is used for the manufacture of acetylcellulose, acetylsalicylic acid, acetanilide, nitrofurane, sulfonamides, vitamin B6 etc. Product Data Sheet
[Sensitive ]

Moisture Sensitive
[Merck ]

[BRN ]


Acetic Anhydride is an esterifier for food starch; also used in combi- nation with adipic anhydride.
[CAS DataBase Reference]

108-24-7(CAS DataBase Reference)
[NIST Chemistry Reference]

Acetic acid anhydride(108-24-7)
[EPA Substance Registry System]

108-24-7(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

[Risk Statements ]

R11:Highly Flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R34:Causes burns.
R20/21:Harmful by inhalation and in contact with skin .
R20/22:Harmful by inhalation and if swallowed .
R19:May form explosive peroxides.
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39:Wear eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S33:Take precautionary measures against static discharges .
S16:Keep away from sources of ignition-No smoking .

UN 2924 3/PG 2
[WGK Germany ]


[F ]

[HazardClass ]

[PackingGroup ]

[HS Code ]

[Safety Profile]

Moderately toxic by inhalation, ingestion, and skin contact. A skin and severe eye irritant. A flammable liquid. A fire and explosion hazard when exposed to heat or flame. Potentially explosive reactions with barium peroxide, boric acid, chromium trioxide, 1,3diphenyltriazene, hydrochloric acid + water, hypochlorous acid, nitric acid, perchloric acid + water, peroxyacetic acid, potassium permanganate, tetrafluoroboric acid, 4toluenesulfonic acid + water, and acetic acid + water. Reactions with ethanol + sodium hydrogen sulfate, and hydrogen peroxide form explosive products. Reactions with ammonium nitrate + hexamethylenetetrammonium acetate + nitric acid form as products the military explosives RDX and HMX. Reacts violently with N-tert-butyl-phthalimic acid + tetrafluoroboric acid, chromic acid, glycerol + phosphoryl chloride, and metal nitrates (e.g., copper or sodium nitrates). Incompatible with 2-aminoethanol, aniline, chlorosulfonic acid, (CrOs + acetic acid), ethylene-diamine, ethyleneimine, glycerol, oleum, HF, permanganates, NaOH, Na2O2, H2SO4, water, N2O2, (glycerol + phosphoryl chloride). When heated to decomposition it emits toxic fumes; can react vigorously with oxidizing materials, wdl react violently on contact with water or steam. Used in production of drugs of abuse. To fight fire, use CO2, dry chemical, water mist, alcohol foam. See also ANHYDRIDES.
[Hazardous Substances Data]

108-24-7(Hazardous Substances Data)
Raw materials And Preparation ProductsBack Directory
【Raw materials】

Ethyl acetate-->Acetic acid-->Ammonia-->Acetyl ketene-->ketene-->Triethyl phosphate-->olefine ketone
【Preparation Products】

4-(METHOXYCARBONYL)NICOTINIC ACID-->1-BENZOTHIOPHENE-3-SULFONYL CHLORIDE-->2-cyano-N-methyl-N-[(methylamino)carbonyl]acetamide-->Magnesium acetate-->N-(2-METHOXY-4-NITROPHENYL)ACETAMIDE-->Antimony triacetate-->water-proofing agent PF-->3-(METHOXYCARBONYL)PYRIDINE-2-CARBOXYLIC ACID-->2-Acetylamino-4-methylpyridine-->3-ACETYL-2,5-DIMETHYLFURAN-->3,4-PYRIDINEDICARBOXIMIDE-->N-Hydroxysulfosuccinimide sodium salt-->N-(6-CHLORO-3-NITROPYRIDIN-2-YL)ACETAMIDE-->4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE-->2-ACETAMIDO-5-PICOLINE-->4-Acetamido-2-chloropyridine-->6-(ACETYLAMINO)-2-PYRIDINECARBOXYLIC ACID-->2-ACETYLAMINO-5-BROMO-6-METHYLPYRIDINE-->1,3-Dimethyl-8-nitro-1H-purine-2,6(3H,9H)-dione ,97%-->(2R,3R)-2-Amino-3-methylpentanoic acid-->6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione-->5-ALPHA-ANDROSTANE-ALPHA-NOR-2,17-DIONE-->DL-THREO-2-ACETAMIDO-L-(4-NITROPHENYL)-L,3-PROPANEDIOL-->Vitamin E-->(6-BROMO-2-PYRIDINYL)-CARBAMIC ACID,1,1-DIMETHYLETHYL ESTER-->7-(Acetylamino)-4-hydroxy-2-naphthalenesulfonic acid-->2-Ethylbutyl acetate-->2-[(Acetyloxy)methoxy]ethyl acetate-->FARNESOL-->4-ACETAMIDO-3-NITROPYRIDINE-->2-ACETAMIDO-3-PICOLINE-->PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE-->19-Nor-17-alpha-pregna-3,5-dien-20-yne-3,17-diol, diacetate-->methyl 2-cyano-3-ethoxyacrylate-->2,4,6-TRIHYDROXY-1,3-DIMETHYL BENZENE-->D-Phenylalanine-->N-Acetyl-L-glutamine-->O-ACETYLRICINOLEIC ACID METHYL ESTER-->CELLULOSE ACETATE-->N-Acetylmorpholine-->Pengitoxin
Hazard InformationBack Directory
[General Description]

A clear colorless liquid with a strong odor of vinegar. Flash point 129°F. Corrosive to metals and tissue. Density 9.0 lb /gal. Used to make fibers, plastics, pharmaceuticals, dyes, and explosives.
[Reactivity Profile]

ACETIC ANHYDRIDE(108-24-7) reacts violently on contact with water, steam, methanol, ethanol, glycerol and boric acid. Reaction with water is particularly dangerous in presence with mineral acids (e.g., nitric, perchloric, chromic, sulfuric acid) [Chem. Eng. News 25, 3458]. Potentially explosive reactions with oxidizing reagents such as barium peroxide, chromium trioxide, chromic acid, hypochlorous acid, nitric acid, perchloric acid, peroxyacetic acid, potassium permanganate, hydrogen peroxide. [Sax, 9th ed., 1996, p. 15]. Reacts violently with metal nitrates used as nitrating agents [Davey W. et al., Chem. & Ind., 1948, p. 814].
[Air & Water Reactions]

Flammable. Reacts violently with water to generate acetic acid . This reaction is heightened by the presence of mineral acids (nitric, perchloric, sulfuric acid, etc.) [Chem. Eng. News 25, 3458].
[Health Hazard]

Liquid is volatile and causes little irritation on uncovered skin. However, causes severe burns when clothing is wet with the chemical or if it enters gloves or shoes. Causes skin and eye burns and irritation of respiratory tract. Nausea and vomiting may develop after exposure.
[Potential Exposure]

Acetic anhydride is used as an acetylating agent or as a solvent in the manufacture of cellulose acetate, acetanilide, aspirin, synthetic fibers, plastics, explosives, resins, perfumes, and flavorings; and it is used in the textile dyeing industry. It is widely used as a pharmaceutical intermediate and as a pesticide intermediate
[First aid]

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately with large amounts of water. If this chemical contacts the skin, quickly remove clothing and immediately wash area with large amounts of water. If a person breathes this chemical, move the exposed person to fresh air at once and perform (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if hearth action hasstopped. When this chemical has been swallowed, get medical attention immediately. If victim is conscious, administer water or milk. Do not induce vomiting

UN1715 Acetic anhydride, Hazard class: 8; Labels: 8-Corrosive material, 3-Flammable liquid.

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, alcohols, chromic acid (violent reaction), amines, strong caustics; finely divided metals. Contact with water forms acetic acid and liberates a large amount of heat. Corrosive to iron, steel and other metals.
[Waste Disposal]

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Acetic anhydride(108-24-7).msds
Questions And AnswerBack Directory

Acetic anhydride (chemical formula: (CH3CO)2O) is the simplest isolable anhydride of a carboxylic acid, is widely used as a reagent in organic synthesis. It has an internal asymmetric structure, leading to its potent electrophilicity. In organic chemistry, it is mainly used in acetylation for the manufacture of commercially significant materials, e.g. it can be used for the conversion of cellulose to cellulose acetate and aspirin. It can also be used as a wood preservative. In starch industry, it is a common acetylation compound for acetylation of monoglyceride. It is also an esterification agent for the production of modified starches. It is produced by carbonylation of methyl acetate or the reaction between ketene and acetic acid.
Spectrum DetailBack Directory
[Spectrum Detail]

Acetic anhydride(108-24-7) Raman
Acetic anhydride(108-24-7) MS
Acetic anhydride(108-24-7) 13C NMR
Acetic anhydride(108-24-7) IR2
Acetic anhydride(108-24-7) 1H NMR
Acetic anhydride(108-24-7) IR1
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

[Alfa Aesar]

Acetic anhydride, ACS, 97+%(108-24-7)
[Sigma Aldrich]


Acetic Anhydride  (ca. 1mol/L in Dichloromethane)(108-24-7)
108-24-7 suppliers list
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