| Identification | More | [Name]
Methyl malonyl chloride | [CAS]
37517-81-0 | [Synonyms]
AURORA KA-3053
METHYL 3-CHLORO-3-OXOPROPIONATE
METHYL CHLOROFORMYLACETATE
METHYL MALONYL CHLORIDE
Propanoic acid, 3-chloro-3-oxo-, methyl ester
Malonic acid monomethyl ester chloride~Methyl (chloroformyl)acetate
Mehtyl Malonyl Chloride
METHYL 3-CHLORO-3-OXOPROPIONATE,97%
Methyl malonyl chloride 97%
Methyl chloroformylacetate, Methyl malonyl chloride
(Chlorocarbonyl)acetic acid methyl ester
(Malonic acid 1-methyl) chloride
3-Chloro-3-oxopropionic acid methyl ester
3-Oxo-3-chloropropanoic acid methyl ester
3-Oxo-3-chloropropionic acid methyl ester | [EINECS(EC#)]
253-540-6 | [Molecular Formula]
C4H4Cl2O2 | [MDL Number]
MFCD00013657 | [Molecular Weight]
154.98 | [MOL File]
37517-81-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear light yellow to yellow liquid | [Boiling point ]
57-59 °C/12 mmHg (lit.) | [density ]
1.273 g/mL at 25 °C(lit.) | [refractive index ]
n20/D 1.432(lit.)
| [Fp ]
176 °F
| [storage temp. ]
2-8°C
| [solubility ]
soluble in Chloroform, Ethyl Acetate | [form ]
Liquid | [pka]
9.33±0.46(Predicted) | [color ]
Colorless | [Specific Gravity]
1.275 | [Water Solubility ]
Reacts with water. | [Sensitive ]
Lachrymatory | [BRN ]
1754078 | [InChI]
1S/C4H5ClO3/c1-8-4(7)2-3(5)6/h2H2,1H3 | [InChIKey]
UTBCRHAMJFMIIR-UHFFFAOYSA-N | [SMILES]
COC(=O)CC(Cl)=O | [CAS DataBase Reference]
37517-81-0(CAS DataBase Reference) | [NIST Chemistry Reference]
Methyl malonyl chloride(37517-81-0) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns.
R36/37:Irritating to eyes and respiratory system . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3265 8/PG 2
| [WGK Germany ]
3
| [F ]
8-10-19 | [Hazard Note ]
Corrosive/Lachrymatory/Keep Cold | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29171900 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Eye Dam. 1
Skin Corr. 1B
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear light yellow to yellow liquid | [Uses]
Methyl malonyl chloride is used as pharmaceutical intermediate. Used in anti-cancer drugs. | [General Description]
Methyl 3-chloro-3-oxopropionate reacts with 4-cyano-1,1′-biphenyl derivatives bearing ω-hydroxyalkyl substituents to yield liquid-crystalline linear malonates and cyanoacetates. | [Synthesis]
Methylmalonyl chloride can be obtained by reacting hydrogen methylmalonate with oxalyl chloride. Take out the 100 mL clean flask from the oven and cool it to room temperature under argon, add 5 mL of methylene chloride and 1.0 g (8.5 mmol) of hydrogen met |
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