| Identification | More | [Name]
4-Chloro-2-hydroxypyridine | [CAS]
40673-25-4 | [Synonyms]
4-CHLORO-2-HYDROXYPYRIDINE
4-CHLORO-2-PYRIDINOL
4-CHLORO-PYRIDIN-2-OL
2(1H)-Pyridinone,4-chloro-(9CI)
4-CHLORO-2-HYDROXYPYRIDINE, 98+% | [EINECS(EC#)]
201-525-2 | [Molecular Formula]
C5H4ClNO | [MDL Number]
MFCD03093022 | [Molecular Weight]
129.54 | [MOL File]
40673-25-4.mol |
| Hazard Information | Back Directory | [Uses]
4-Chloro-2-hydroxypyridine serves as a precursor for the synthesis of 4-chloropyridin-2-yl trifluoromethanesulfonate [1]. | [Synthesis]
4-Chloro-2-hydroxypyridine forms via chlorination and elimination reactions involving HCl loss and decarboxylation that facilitate cyclization, and is also generated during controlled chloramination and chlorination of surface water [2]. | [References]
[1] Reeves, E. K., Humke, J. N., & Neufeldt, S. R. (2019). N-Heterocyclic Carbene Ligand-Controlled Chemodivergent Suzuki–Miyaura Cross Coupling. The Journal of Organic Chemistry, 84(18), 11799–11812. https://doi.org/10.1021/acs.joc.9b01692
[2] Wang, P., Ye, B., Nomura, Y., & Fujiwara, T. (2025). Emerging heterocyclic nitrogenous disinfection byproducts: Occurrence, precursors, and mechanisms of halogenated pyridines. Journal of Environmental Chemical Engineering, 13(6), 120309. https://doi.org/10.1016/j.jece.2025.120309 |
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