| Identification | Back Directory | [Name]
JNJ 16259685 | [CAS]
409345-29-5 | [Synonyms]
CS-2455
JNJ16259865
JNJ 16259685
.TN.T 16259685
3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl-(4-methoxycyclohexyl)methanone
(3,4-DIHYDRO-2H-PYRANO[2,3-B]QUINOLIN-7-YL)-(CIS-4-METHOXYCYCLOHEXYL)-METHANONE | [Molecular Formula]
C20H23NO3 | [MDL Number]
MFCD08690525 | [MOL File]
409345-29-5.mol | [Molecular Weight]
325.4 |
| Chemical Properties | Back Directory | [Melting point ]
102-104°C | [Boiling point ]
502.5±50.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
Chloroform (Slightly), DMSO (Slightly) | [form ]
White to off-white solid. | [pka]
2.60±0.20(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
JNJ 16259685 is a metabotropic glutamate receptor-1 antagonist that alters select behavior in mouse model of fragile X syndrome. | [Definition]
ChEBI: 3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl-(4-methoxycyclohexyl)methanone is an organonitrogen heterocyclic compound, an oxacycle and an organic heterotricyclic compound. | [in vivo]
JNJ16259685 (0.125, 0.25, 0.5, 1, 2, 4 and 8 mg/kg, i.p) significantly reduces the time spent in digging behaviours (0.25-8 mg/kg), threat (all doses) and attack, in comparison with vehicle group[1]. JNJ16259685 (30 mg/kg) produces very minimal effects on locomotor activity. JNJ16259685 dramatically reduces rearing behavior, exploration of a novel environment and lever pressing for a food reward (rat: 0.3 mg/kg; mouse: 1 mg/kg). Subcutaneously administered JNJ16259685 (30 mg/kg) has no effect on reflexive startle responses to loud auditory stimuli or foot shock in mice[2]. JNJ16259685 exhibits high potencies in occupying central mGlu1 receptors in the rat cerebellum and thalamus (ED50=0.040 and 0.014 mg/kg, respectively)[3]. | [IC 50]
mGluR1: 19 nM (IC50) | [storage]
+4°C |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
|