| Identification | More | [Name]
alpha-Methyldopa sesquihydrate | [CAS]
41372-08-1 | [Synonyms]
(-)-3-(3,4-DIHYDROXYPHENYL)-2-METHYL-L-ALANINE SESQUIHYDRATE
3-(3,4-DIHYDROXYPHENYL)-2-METHYL-L-ALANINE SESQUIHYDRATE
3-HYDROXY-ALPHA-METHYL-L-TYROSINE SESQUIHYDRATE
3-hydroxy-b-methyl-l-tyrosine hydrate
ALPHA-METHYL-DOPA SESQUIHYDRATE
(-)-ALPHA-METHYL-L-DOPA SESQUIHYDRATE
ALPHA-METHYL-L-DOPA SESQUIHYDRATE
methyl dopa sesquihydrate
(S)-2-AMINO-3-(3,4-DIHYDROXYPHENYL)-2-METHYLPROPIONIC ACID SESQUIHYDRATE
3-hydroxy-alpha-methyl-l-tyrosinhydrate(2:3)
hyperpax
L-METHYL DOPA USP24
L-Methyldopa sesquihydrate
3-(3,4-DIHYDROXYPHENYL)-2-METHYL-
MethyldopaUsp25
(-)-3-(3,4-Dihydroxyphenyl)-2-methyl-L-alaninesesquihydrate,99%
-METHYL-L-DOPA SESQUIHYDRATE
L-Tyrosine, 3-hydroxy-.alpha.-methyl-, hydrate (2:3)
à-methyl-l-dopa
L-(-)-ALPHA-METHYLDOPA ((-)-3-(3,4-DIHYDROXYPHENYL)-2-METHYL-L-ALANINE SESQUIHYDRATE) | [EINECS(EC#)]
209-089-2 | [Molecular Formula]
C10H15NO5 | [MDL Number]
MFCD00149280 | [Molecular Weight]
229.23 | [MOL File]
41372-08-1.mol |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
>300 °C(lit.)
| [storage temp. ]
2-8°C | [solubility ]
Slightly soluble in water, very slightly soluble in ethanol (96 per cent). It is freely soluble in dilute mineral acids. | [form ]
neat | [color ]
White to Off-White | [Stability:]
Stable, but may be light sensitive. Very hygroscopic. Undergoes catalytic oxygenation in the presence of magnesium, cupric, cobalt, nickel and ferric ions. Store under a dry atmosphere. | [Optical Rotation]
[α]25/D 13°, c = 1 in H2O | [Water Solubility ]
0.1-1 g/100 mL at 23 ºC | [Sensitive ]
Air & Light Sensitive | [Usage]
Antihypertensive agent | [Merck ]
13,6080 | [BRN ]
2417244 | [Major Application]
peptide synthesis | [InChI]
InChI=1/C10H13NO4.H2O/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6;/h2-4,12-13H,5,11H2,1H3,(H,14,15);1H2/t10-;/s3 | [InChIKey]
XDJUBZFLFDODNF-MEQOOBBNNA-N | [SMILES]
[C@@](N)(C)(CC1C=CC(O)=C(O)C=1)C(=O)O.O |&1:0,r| | [CAS DataBase Reference]
41372-08-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302 | [Precautionary statements ]
P280-P305+P351+P338 | [Risk Statements ]
R20/21:Harmful by inhalation and in contact with skin .
R36/37/38:Irritating to eyes, respiratory system and skin .
R42/43:May cause sensitization by inhalation and skin contact .
R65:Harmful: May cause lung damage if swallowed. | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
YP2860000
| [F ]
10-23 | [HS Code ]
2922504500 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Antihypertensive agent | [Uses]
Antihypertensive agent. | [Uses]
Potent inhibitor of invertase and glucosidase inhibitor with a different specificity of action to DNJ and castanospermine. Inhibits glucosidase I.? | [reaction suitability]
reaction type: solution phase peptide synthesis | [Biological Activity]
l-(-)-α-methyldopa (hydrate) is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive. | [Purification Methods]
Recrystallise methyldopa from H2O. [Reinhold et al. J Org Chem 33 1209 1968.] The L-isomer forms a sesquihydrate from H2O m 302-304o (dec), and the anhydrous crystals are hygroscopic,[] 23D -4.0o (c 1, 0.1N HCl), []546 +154.5o (c 5, CuSO4 solution). It has max at 281nm ( 2780). Its solubility in H2O at 25o is ~10mg/mL and the pH of an aqueous solution is ~5.0. It is insoluble in most organic solvents. [Stein et al. J Am Chem Soc 77 700 1955, Beilstein 4 IV 2505.] |
|
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Sinfachem Limited Gold
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025-84683399 13952017251 |
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http://www.sinfachem.com |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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