| Identification | More | [Name]
2-Amino-4-cyanopyridine | [CAS]
42182-27-4 | [Synonyms]
2-AMINO-4-CYANOPYRIDINE
4-PYRIDINECARBONITRILE, 2-AMINO-
2-Aminoisonicotinonitrile
4-Cyano-2-pyridinamine
5-AMINO-4-CYANOPYRIDINE
2-Amino-4-pyridinecarbonitrile | [EINECS(EC#)]
677-660-7 | [Molecular Formula]
C6H5N3 | [MDL Number]
MFCD03791310 | [Molecular Weight]
119.12 | [MOL File]
42182-27-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
146-148°C | [Boiling point ]
297.7±20.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
3.93±0.11(Predicted) | [Appearance]
Off-white to light yellow Solid | [Water Solubility ]
Slightly soluble in water. | [Usage]
A pyridine derivative as mGluR2 antagonists; used in the treatment of CNS disorders. | [BRN ]
386393 | [InChI]
InChI=1S/C6H5N3/c7-4-5-1-2-9-6(8)3-5/h1-3H,(H2,8,9) | [InChIKey]
GEEAYLFEIFJFGP-UHFFFAOYSA-N | [SMILES]
C1(N)=NC=CC(C#N)=C1 | [CAS DataBase Reference]
42182-27-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS06 | [Signal word ]
Warning | [Hazard statements ]
H301-H311-H319 | [Precautionary statements ]
P280f-P305+P351+P338-P309-P310 | [Hazard Codes ]
Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36:Wear suitable protective clothing . | [RIDADR ]
3439 | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Description]
2-Amino-4-cyanopyridine is a pharmaceutical intermediate compound with two functional groups—an amino group and a cyano group—in its molecular structure, which are the primary factors contributing to its reactivity. It can also be used as a cyanide source for the preparation of organic light-emitting materials. | [Chemical Properties]
Yellow or pale brown cryst powder | [Uses]
2-Amino-4-cyanopyridine is a pyridine derivative as mGluR2 antagonists; used in the treatment of CNS disorders.
| [Synthesis]
Step 5: A mixture of 4-bromopyridin-2-amine (4.9 g, 28.5 mmol), zinc cyanide (5.0 g, 42.5 mmol), tris(dibenzylideneacetone)dipalladium (1.3 g, 1.4 mmol), and 1,1'-bis(diphenylphosphino)ferrocene (1.6 g, 2.8 mmol) was dissolved in N,N-dimethylformamide (150 mL). The reaction mixture was stirred at 100 °C for 1.5 h under nitrogen protection. After completion of the reaction, the mixture was cooled to room temperature and diluted with water (500 mL). The mixture was extracted with ethyl acetate (300 mL x 3). The organic layers were combined, washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent petroleum ether/ethyl acetate (10:1 to 2:1) to afford 2-amino-4-cyanopyridine as a light yellow solid (2.7 g, 80% yield).1H NMR (300 MHz, CDCl3) δ 8.19 (d, J = 5.1 Hz, 1H), 6.82 (d, J = 4.8 Hz, 1H) 6.69 (d, J = 0.9 Hz, 1H), 4.72 (br s, 2H).LCMS (ESI) m/z 120 (M + H)+. | [References]
[1] Patent: EP2766359, 2016, B1. Location in patent: Paragraph 117.5 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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| Telephone: |
0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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