| Identification | More | [Name]
1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine | [CAS]
4271-96-9 | [Synonyms]
1,2-DIMETHYL-1,4,5,6-TETRAHYDROPYRIMIDINE
1,4,5,6-TETRAHYDRO-1,2-DIMETHYLPYRIMIDINE
DMTHPM
1,4,5,6-tetrahydro-1,2-dimethyl-pyrimidin
Pyrimidine,1,4,5,6-tetrahydro-1,2-dimethyl-
1,2-Dimethyl-1,4,5,6-Tetrahydropyrimidne | [EINECS(EC#)]
224-262-2 | [Molecular Formula]
C6H12N2 | [MDL Number]
MFCD00036056 | [Molecular Weight]
112.17 | [MOL File]
4271-96-9.mol |
| Chemical Properties | Back Directory | [Boiling point ]
125°C (115 mmHg) | [density ]
0,98 g/cm3 | [Fp ]
73°C | [storage temp. ]
2-8°C | [solubility ]
Acetone (Sparingly), Chloroform (Sparingly), DMSO (Sparingly), Methanol(Sparingly) | [form ]
Oil | [pka]
13.42±0.20(Predicted) | [color ]
Clear Colourless | [Specific Gravity]
0.982 (20/4℃) | [InChI]
1S/C6H12N2/c1-6-7-4-3-5-8(6)2/h3-5H2,1-2H3 | [InChIKey]
ZFDWWDZLRKHULH-UHFFFAOYSA-N | [CAS DataBase Reference]
4271-96-9(CAS DataBase Reference) | [EPA Substance Registry System]
Pyrimidine, 1,4,5,6-tetrahydro-1,2-dimethyl- (4271-96-9) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R22:Harmful if swallowed.
R34:Causes burns. | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
3267 | [WGK Germany ]
WGK 3 | [TSCA ]
TSCA listed | [HS Code ]
2933599590 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Uses]
1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine is a reagent used in the synthesis of pyrantel derivatives with nematocidal activity. Also used as a reactant in the preparation of hapten antibodies that evoke terpenoid cyclization. | [Synthesis]
General procedure for the synthesis of 1,2-dimethyl-1,4,5,6-tetrahydropyrimidine from N-[3-(methylamino)propyl]-acetamide: N-[3-(methylamino)propyl]-acetamide obtained from the previous step was dissolved in 200 mL of polyphosphoric acid ester (PPE) and placed in a microwave reactor. The reaction temperature was controlled to be 80 °C and the reaction time was 2 hours. After completion of the reaction, the reaction mixture was purified to afford the target product 1,2-dimethyl-1,4,5,6-tetrahydropyrimidine 240 g in 94.42% yield. | [References]
[1] Patent: CN108822044, 2018, A. Location in patent: Paragraph 0025; 0028; 0031; 0032; 0037; 0042; 0047-0057 |
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