| Identification | More | [Name]
4-Fluoro-2-methylaniline | [CAS]
452-71-1 | [Synonyms]
2-AMINO-5-FLUOROTOLUENE
3-FLUORO-6-AMINOTOLUENE
4-FLUORO-2-METHYLANILINE
4-fluoro-2-methylbenzeneamine
4-FLUORO-O-TOLUIDINE
2-Methyl-4-fluoroaniline
4-fluoro-2-methyl-benzenamin
4-Fluoro-2-methylbenzenamine
6-Amino-3-fluorotoluene
o-Toluidine, 4-fluoro-
4-fluorotoluidine
4-Fluoro-2-methylaniline 97%
4-Fluoro-2-methylaniline97%
2-Amino-5-fluorotoluene, 4-Fluoro-o-toluidine
2-Fluoro-o-toluidine
Benzenamine, 4-fluoro-2-methyl- | [EINECS(EC#)]
207-208-2 | [Molecular Formula]
C7H8FN | [MDL Number]
MFCD00007832 | [Molecular Weight]
125.14 | [MOL File]
452-71-1.mol |
| Chemical Properties | Back Directory | [Appearance]
colorlesstolightyellowliqui | [Melting point ]
14.2°C | [Boiling point ]
90-92 °C/16 mmHg (lit.) | [density ]
1.126 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.537(lit.)
| [Fp ]
190 °F
| [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
clear liquid | [pka]
4.51±0.10(Predicted) | [color ]
Light yellow to Yellow to Orange | [Specific Gravity]
1.126 | [BRN ]
1931798 | [InChI]
1S/C7H8FN/c1-5-4-6(8)2-3-7(5)9/h2-4H,9H2,1H3 | [InChIKey]
KMHLGVTVACLEJE-UHFFFAOYSA-N | [SMILES]
Cc1cc(F)ccc1N | [CAS DataBase Reference]
452-71-1(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzenamine, 4-fluoro-2-methyl-(452-71-1) | [EPA Substance Registry System]
452-71-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,T,Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36:Wear suitable protective clothing . | [RIDADR ]
2810 | [WGK Germany ]
3
| [RTECS ]
CY0500000
| [Hazard Note ]
Toxic/Irritant | [TSCA ]
T | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29214300 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
colorlesstolightyellowliqui | [Uses]
4-Fluoro-2-methylaniline was used in the synthesis of 4-fluoro-N-[(E)-{7-methoxy-2-[4-(methylsulfanyl)phenyl]-1-benzofuran-5-yl}methylidene]-2-methylaniline. | [Synthesis]
General procedure for the synthesis of 4-fluoro-2-methylaniline from 5-fluoro-2-nitrotoluene: 10% palladium/carbon (Pd/C, 21 mg, 0.020 mmol) was added to a solution of 4-fluoro-2-methyl-1-nitrobenzene (3b, 243 mL, 2.00 mmol) in methanol (MeOH, 10 mL). The reaction mixture was stirred at room temperature and bubbled with hydrogen (H2) for 2 hours. Upon completion of the reaction, the solid catalyst was removed by filtration and the solids were washed with dichloromethane (DCM, 25 mL). The filtrate and DCM wash solution were combined and concentrated under reduced pressure. The residue was purified by fast column chromatography (silica gel, petroleum ether (P.E.) gradient elution to petroleum ether:ethyl acetate (PE:EtOAc) 4:1) to afford 4-fluoro-2-methylaniline (4b) as a pink oil (250 mg, 100% yield). | [References]
[1] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 539 - 550
[2] Collection of Czechoslovak Chemical Communications, 1984, vol. 49, # 1, p. 86 - 109
[3] Synlett, 2007, # 16, p. 2557 - 2558
[4] Acta Chemica Scandinavica (1947-1973), 1955, vol. 9, p. 1079,1083
[5] Chemische Berichte, 1929, vol. 62, p. 1804 |
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Alfa Aesar
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Energy Chemical
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Jia Xing Isenchem Co.,Ltd
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