| Identification | More | [Name]
4-Bromo-3-fluorotoluene | [CAS]
452-74-4 | [Synonyms]
3-FLUORO-4-BROMO-TOLUENE
4-BROMO-3-FLUOROTOLUENE
4-Bromo-3-fluorotoluene,98+%
4-Bromo-3-fluorotoluene 98%
4-Bromo-3-fluoro-1-methylbenzene
4-Bromo-3-flurotoluene
3-FLUORO-4-BROMO-TOLUONE | [EINECS(EC#)]
629-423-4 | [Molecular Formula]
C7H6BrF | [MDL Number]
MFCD00040940 | [Molecular Weight]
189.02 | [MOL File]
452-74-4.mol |
| Chemical Properties | Back Directory | [Appearance]
colorless to light yellow liqui | [Boiling point ]
95 °C/50 mmHg (lit.) | [density ]
1.494 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.53(lit.)
| [Fp ]
95 °F
| [storage temp. ]
Flammables area | [form ]
Liquid | [color ]
Clear light yellow | [Specific Gravity]
1.494 | [BRN ]
2500154 | [InChI]
InChI=1S/C7H6BrF/c1-5-2-3-6(8)7(9)4-5/h2-4H,1H3 | [InChIKey]
SLFNGVGRINFJLK-UHFFFAOYSA-N | [SMILES]
C1(Br)=CC=C(C)C=C1F | [CAS DataBase Reference]
452-74-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R10:Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 1993 3/PG 3
| [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29039990 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
colorless to light yellow liqui | [Uses]
4-Bromo-3-fluorotoluene is used in the synthesis of S-trityl-L-cysteine based inhibitors that show potent antitumor activity in lung cancer models. Chemical reagent for organic synthesis. | [General Description]
4-Bromo-3-fluorotoluene (1-bromo-2-fluoro-4-methylbenzene) is an aryl fluorinated building block. Synthesis of 4-bromo-3-fluorotoluene from o-nitro-p-toluidine (Fast Red Base GL), via diazo reaction at high temperature, Sandmeyer reaction, reduction and Schiemann reaction has been reported. Its density and refractive index have been determined. | [Synthesis]
the preparation method of a 4-Bromo-3-fluorotoluene, it is
characterized in that: 4-amino-3-toluene fluoride hydrobromate, Hydrogen
bromide, water drips Sodium Nitrite/water down at-10-10 ℃ and carries
out diazotization, reaction solution joins in cuprous
bromide/hydrobromic solution, and bromination under the normal
temperature was reacted 0.5-2 hour, separate, purifying obtains target
product 4-Bromo-3-fluorotoluene. | [References]
[1] Method for preparing 4-bromine-3-fluorine methylbenzene. CN1274650C |
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