| Identification | More | [Name]
Propyphenazone | [CAS]
479-92-5 | [Synonyms]
4-ISOPROPYL-1,5-DIMETHYL-2-PHENYL-3-PYRAZOLONE
4-ISOPROPYL-2,3-DIMETHYL-1-PHENYL-5-PYRAZOLONE
4-ISOPROPYLANTIPYRINE
ISOPROPYLANTIPYRINE
ISOPROPYLANTIPYRINUM
ISOPROPYLPHENAZONE
PROPYPHENAZONE
1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3h-pyrazol-3-on
1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3H-Pyrazol-3-one
1,2-dihydro-1,5-dimethyl-4-(isopropyl)-2-phenyl-pyrazol-3-one
1-Phenyl-2,3-dimethyl-4-isopropyl-3-pyrazolin-5-one
1-phenyl-2,3-dimethyl-4-isopropyl-5-Pyrazolone
1-Phenyl-2,3-dimethyl-4-isopropylpyrazol-5-one
2,3-Dimethyl-4-isopropyl-1-phenyl-3H-pyrazolin-5-one
2,3-dimethyl-4-isopropyl-1-phenyl-3-pyrazolin-5-on
3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-
3H-Pyrazol-3-one,1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-
3-Pyrazolin-5-one, 2,3-dimethyl-4-isopropyl-1-phenyl-
3-Pyrazolin-5-one, 4-isopropyl-2,3-dimethyl-1-phenyl-
4-Isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one | [EINECS(EC#)]
207-539-2 | [Molecular Formula]
C14H18N2O | [MDL Number]
MFCD00053368 | [Molecular Weight]
230.31 | [MOL File]
479-92-5.mol |
| Chemical Properties | Back Directory | [Appearance]
solid | [Melting point ]
102-105°C | [Boiling point ]
372.3°C (rough estimate) | [density ]
1.0371 (rough estimate) | [refractive index ]
1.5500 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Slightly soluble in water, freely soluble in ethanol (96 per cent) and in methylene chloride. | [form ]
neat | [pka]
1.46±0.65(Predicted) | [color ]
White to Off-White | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
743.6g/L(25.35 ºC) | [Merck ]
7871 | [BRN ]
204533 | [CAS DataBase Reference]
479-92-5(CAS DataBase Reference) | [NIST Chemistry Reference]
Propyphenazone(479-92-5) | [EPA Substance Registry System]
479-92-5(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3 | [RTECS ]
CD2800000 | [TSCA ]
TSCA listed | [HS Code ]
2933.39.9200 |
| Hazard Information | Back Directory | [Description]
This uncharacterized alkaloid has been described by Hartsen as occurring in Iso_x0002_pyrum thalictroides L. No chemical or physical characteristics are known. | [Chemical Properties]
solid | [Uses]
Analgesic; antipyretic; anti-inflammatory. | [Definition]
ChEBI: A pyrazolone derivative that is antipyrine substituted at C-4 by an isopropyl group. | [Brand name]
539 grippe-dragees;Amipylo-n;Balpiren;Baukal;Caffalgina;Camoplex;Cantacin;Cerebrol;Daturmed;Degripol;Dentocaps a;Dim-antos;Dolibral;Dolo-mineuron;Dysmalgin;Ejcopyrin;Epizon;Escomen;Estesina;Fd 8;Febral;Finigripp;Grippocaps;Heaven;Infantex;Influvit;Isopronazon;Kavapyret;Kuronde;Lysadestat;Mamaslu;Milneuron;Myo-europan;Neuramin;Neuridal;Neuro-spondryl;Nodiras;Noric;Otobacid;Pfeil;Reomin;Retamex;Rheumanol;Rhinivict;Sanalgin-p;Saridon neu;Saridone;Sedospin;Servalgin;Sonotryl;Spalt;Spongamed;Stona;Synpyrin;Vivcet;Wauco-sin;Wecontrin. | [World Health Organization (WHO)]
Propyphenazone, a pyrazolone derivative with anti-inflammatory,
analgesic and antipyretic activity, was introduced in 1951 for the treatment of
rheumatic disorders. As it is structurally related to aminophenazone it has been
associated with severe blood dyscrasias. However, it cannot be transformed into
potentially carcinogenic nitrosamines and has therefore been widely used as a
replacement drug for aminophenazone. In certain countries, products containing
propyphenazone have now been restricted in their indications, whereas in others
they are still available, sometimes as over-the-counter preparations. See also WHO
comment for aminophenazone. | [Clinical Use]
Propyphenazone is a
derivative of phenazone and has a similar analgesic
and antipyretic action. It is used as a monocompound
as well as in multi-ingredient preparations. | [References]
Hartsen., J. Chem. Soc., 511 (1873)
Mirande., Compt. rend., 168,316 (1919) |
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