| Identification | More | [Name]
Isopropyl ether | [CAS]
108-20-3 | [Synonyms]
2-ISOPROPOXYPROPANE
DIISOPROPYL ETHER
DIPE
I,I'-DIMETHYLDIETHYL ETHER
ISOPROPYL ETHER
(iso-C3H7)2O
1,1'-Dimethyldiethyl ether
1-methyl-1-(1-methylethoxy)ethane
2,2’-oxybis-propan
2,2’-oxybispropane
2,2’-oxybis-Propane
2,2'-Oxybispropane
2,4-dimethyl-3-oxapentane
bis-(1-Methylethyl)ether
bis(1-methylethyl)ether
Bis(isopropyl) ether
bis(isopropyl)ether
di-(1-methylethyl)ether
di(2-propyl)ether
Diiospropyl ether | [EINECS(EC#)]
203-560-6 | [Molecular Formula]
C6H14O | [MDL Number]
MFCD00008880 | [Molecular Weight]
102.17 | [MOL File]
108-20-3.mol |
| Chemical Properties | Back Directory | [Appearance]
colourless liquid | [Melting point ]
-85.5 °C | [Boiling point ]
68-69 °C(lit.)
| [density ]
0.725 g/mL at 25 °C(lit.)
| [vapor density ]
3.5 (vs air)
| [vapor pressure ]
120 mm Hg ( 20 °C)
| [refractive index ]
n20/D 1.367(lit.)
| [Fp ]
−29 °F
| [storage temp. ]
Flammables area | [solubility ]
3.11g/l | [form ]
Liquid | [color ]
APHA: ≤25 | [Odor]
Sweet, slightly sharp; characteristic pungent; ethereal; like amphor and ethyl ether. | [Relative polarity]
2.2 | [Stability:]
Extremely flammable. This material is a serious fire and explosion risk. Vapour may travel considerable distances to an ignition source, which need not be an open flame, but may be a hot plate, steam pipe, etc. Vapour may be ignited by the static electricty which can build up when isopropyl ether is being poured from one vessel | [explosive limit]
1-21%, 100°F | [Water Solubility ]
9 g/L (20 ºC) | [Merck ]
14,5212 | [BRN ]
1731256 | [Henry's Law Constant]
2.57 at 25 °C (headspace-GC, Arp and Schmidt, 2004) | [Dielectric constant]
3.9（25℃） | [Exposure limits]
TLV-TWA 1045 mg/m3 (250 ppm) (ACGIH),
2090 mg/m3 (500 ppm) (OSHA); STEL
1300 mg/m3 (310 ppm) (ACGIH). | [LogP]
2.4 at 20℃ | [CAS DataBase Reference]
108-20-3(CAS DataBase Reference) | [NIST Chemistry Reference]
Diisopropyl ether(108-20-3) | [EPA Substance Registry System]
108-20-3(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
F | [Risk Statements ]
R11:Highly Flammable.
R19:May form explosive peroxides.
R66:Repeated exposure may cause skin dryness or cracking.
R67:Vapors may cause drowsiness and dizziness. | [Safety Statements ]
S9:Keep container in a well-ventilated place .
S16:Keep away from sources of ignition-No smoking .
S29:Do not empty into drains .
S33:Take precautionary measures against static discharges . | [RIDADR ]
UN 1159 3/PG 2
| [WGK Germany ]
1
| [RTECS ]
TZ5425000
| [F ]
10 | [Autoignition Temperature]
827 °F | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29091990 | [Hazardous Substances Data]
108-20-3(Hazardous Substances Data) | [Toxicity]
LD50 in 14 day old, young adult, adult rats (ml/kg): 6.4, 16.5, 16.0 orally (Kimura) | [IDLA]
1,400 ppm [10% LEL] |
| Hazard Information | Back Directory | [General Description]
A clear colorless liquid with an ethereal odor. Flash point-18°F. Less dense than water. Vapors heavier than air. | [Reactivity Profile]
Ethers, such as DIISOPROPYL ETHER, can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert. Mixing diisopropyl ether in equal molar portions with any of the following substances in a closed container caused the temperature and pressure to increase: chlorosulfonic acid, nitric acid, [NFPA 1991]. | [Air & Water Reactions]
Highly flammable. Slightly soluble in water. Form explosive peroxide in storage. A flask of DIISOPROPYL ETHER(108-20-3) was heated on a steam bath with gentle shaking when an explosion occurred. In a second instance, an explosion occurred after practically all the ether had been distilled, [MCA Guide for Safety(1972)]. | [Hazard]
Flammable, dangerous fire risk, explosive
limits in air 1.4–21%. Toxic by inhalation, strong
irritant. | [Health Hazard]
Inhalation causes anesthesia, nausea, headache, dizziness, and irritation of the eyes and nose. Contact of liquid with eyes causes only minor injury; repeated contact with skin will remove natural oils and may cause dermatitis. | [Fire Hazard]
Behavior in Fire: Vapor is heavier than air and may travel a considerable distance to a source of ignition and flash back. Containers may explode when heated. | [Description]
Isopropyl ether (diisopropyl ether) is highly flammable, with a wide flammable range of 1.4%–21% in air. Boiling point is 156°F (68°C), flash point is ?18°F (?27°C), and ignition temperature is 830°F (443°C). Vapor density is 3.5, which is heavier than air. In addition to flammability, isopropyl ether is toxic by inhalation and a strong irritant, with a TLV of 250 ppm in air. | [Chemical Properties]
colourless liquid | [Physical properties]
Clear, colorless, volatile, flammable liquid with a penetrating, sweet, ether-like odor.
Experimentally determined detection and recognition odor threshold concentrations were 70 μg/m3
(17 ppbv) and 220 μg/m3 (53 ppbv), respectively (Hellman and Small, 1974). | [Uses]
As solvent; fuel additive. | [Uses]
Isopropyl ether is used as a solvent for oils,waxes, resins, and dyes; and as a varnishremover. | [Uses]
Solvent; chemical intermediate | [Preparation]
Diisopropyl ether can be prepared by liquid-phase dehydration of 2-propanol at 130 – 190°C and 1.96– 7.85 MPa over acidic catalysts containing aluminum. | [Flammability and Explosibility]
Highlyflammable | [Chemical Reactivity]
Reactivity with Water: No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Unstable peroxides may form if the product contacts air for long time periods. These may explode spontaneously or when heated; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent. | [Industrial uses]
Isopropyl ether is a solvent of minor importance since its boiling point is
intermediate between the two widely used solvents diethyl ether and acetone.
Hazardous peroxides are formed more readily in isopropyl ether than in other
dialkyl ethers. | [Potential Exposure]
ReproductiveEffector; Human Data; Primary Irritant. This material isused as a solvent, additive for gasoline, and a chemicalintermediate. | [First aid]
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit. | [Source]
Some unleaded gasoline may contain isopropyl ether and other oxygenates as an octane
booster and to prevent engine knock. | [Environmental Fate]
Biological. Bridié et al. (1979) reported BOD and COD values of 0.19 and 1.75 g/g using
filtered effluent from a biological sanitary waste treatment plant. These values were determined
using a standard dilution method at 20 °C and stirred for a period of 5 d. The ThOD for isopropyl
ether is 2.82 g/g.
Chemical/Physical. May form explosive peroxides on standing with air (NIOSH, 1997).
At an influent concentration of 1,018 mg/L, treatment with GAC resulted in an effluent
concentration of 203 mg/L. The adsorbability of the GAC used was 162 mg/g carbon (Guisti et al.,
1974).
Isopropyl will not hydrolyze in water except at elevated temperatures and low pH. | [storage]
Isopropyl ether is stored in a flammable-liquids storage room, isolated from combustible and oxidizing materials. It shouldalso be protected from direct sunlight, staticelectricity, and lightning. It is stabilized with0.01% hydroquinone or p-benzylaminphenol.The ether is shipped in amber glass bottles,steel cans, and drums. | [Shipping]
This compound requires a shipping label of“FLAMMABLE LIQUID.” It falls in Hazard Class 3 andPacking Group II. | [Purification Methods]
Common impurities are water and peroxides [detected by the liberation of iodine from weakly acid (HCl) solutions of 2% KI]. Peroxides can be removed by shaking with aqueous Na2SO3 or with acidified ferrous sulfate (0.6g FeSO4 and 6mL conc H2SO4 in 110mL of water, using 5-10g of solution per L of ether), or aqueous NaBH4 solution. The ether is then washed with water, dried with CaCl2 and distilled. Alternatively, refluxing with LiAlH4 or CaH2, or drying with CaSO4, then passage through an activated alumina column, can be used to remove water and peroxides. Other dehydrating agents used with isopropyl ether include P2O5, sodium amalgam and sodium wire. (The ether is often stored in brown bottles, or in the dark, with sodium wire.) Bonner and Goishi (J Am Chem Soc 83 85 1961) treated isopropyl ether with dilute sodium dichromate/sulfuric acid solution, followed by repeated shaking with a 1:1 mixture of 6M NaOH and saturated KMnO4. The ether is washed several times with water, dilute aqueous HCl, and water, with a final washing with, and storage over, ferrous ammonium sulfate acidified with H2SO4. Blaustein and Gryder (J Am Chem Soc 79 540 1957), after washing with alkaline KMnO4, then water, treated the ether with ceric nitrate in nitric acid, and again washed it with water. Hydroquinone is added before drying with CaCl2 and MgSO4, and refluxing with sodium amalgam (108g Hg/100g Na) for 2hours under nitrogen. The distillate (nitrogen atmosphere) is made 2 x 10-5M in hydroquinone to inhibit formation of peroxides (which is negligible if the ether is stored in the dark). Catechol (pyrocatechol) and resorcinol are alternative inhibitors. [Beilstein 1 IV 1471.] | [Incompatibilities]
Forms explosive mixture with air. Aircontact forms explosive peroxides that may explode withheat or shock. Contact with strong oxidizers or strong acidsmay cause a fire and explosion hazard. Attacks some plastics, rubber, and coatings. | [Waste Disposal]
Isopropyl ether is burned in a chemicalincinerator equipped with an afterburner andscrubber. A small amount of ether, if free ofperoxides, can be evaporated in a fume hoodin the absence of any open flame or sourceof ignition nearby. |
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