| Identification | More | [Name]
4-Chloro-2-methylthiopyrimidine | [CAS]
49844-90-8 | [Synonyms]
4-CHLORO-2-(METHYLTHIO)PYRIMIDINE
PYRIMIDINE, 4-CHLORO-2-(METHYLTHIO)-
4-Chloro-2-(methylmercapto)pyrimidine
4-CHLORO-2-METHYLSULFANYL-PYRIMIDINE
4-Chloro-2-(methylthio)pyrimidine 97%
2-methylthio-4-chloropyrimine
2-(Methylthio)-4-chloropyrimidine
4-Chloro-2-(methylthio)pyrimidine ,98% | [EINECS(EC#)]
256-500-6 | [Molecular Formula]
C5H5ClN2S | [MDL Number]
MFCD00006083 | [Molecular Weight]
160.62 | [MOL File]
49844-90-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear yellow to brown liquid | [Melting point ]
−2 °C(lit.)
| [Boiling point ]
139-140 °C36 mm Hg(lit.)
| [density ]
1.381 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.6(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
liquid | [pka]
-0.56±0.20(Predicted) | [color ]
Colorless to Red to Green | [Water Solubility ]
Not miscible or difficult to mix in water. | [Sensitive ]
Hygroscopic | [Detection Methods]
HPLC | [BRN ]
118042 | [InChI]
InChI=1S/C5H5ClN2S/c1-9-5-7-3-2-4(6)8-5/h2-3H,1H3 | [InChIKey]
DFOHHQRGDOQMKG-UHFFFAOYSA-N | [SMILES]
C1(SC)=NC=CC(Cl)=N1 | [CAS DataBase Reference]
49844-90-8(CAS DataBase Reference) | [Storage Precautions]
Moisture sensitive |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS05 | [Signal word ]
Danger | [Hazard statements ]
H314 | [Precautionary statements ]
P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405 | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 1760 8/PG 2
| [WGK Germany ]
3
| [F ]
10-13-23 | [Hazard Note ]
Corrosive/Hygroscopic | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29335990 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Skin Corr. 1B |
| Hazard Information | Back Directory | [Chemical Properties]
Clear yellow to brown liquid | [Uses]
4-Chloro-2-methylthiopyrimidine was used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It was used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors. It was used as building block in medicinal chemistry synthesis. | [Uses]
It finds it application as a building block used in medicinal chemistry synthesis. 4-Chloro-2-methylthiopyrimidine is used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It is also used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors. | [Synthesis]
4-Chloro-2-methylthiopyrimidine can be produced from 2-thiouracil as raw material, dimethyl sulfate as methylation reagent, and thionyl chloride and phosphorus oxychloride as chlorination reagents by methylation and chlorination reaction. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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