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51013-67-3

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51013-67-3 Structure

51013-67-3 Structure
IdentificationMore
[Name]

4-(Morpholinomethyl)aniline
[CAS]

51013-67-3
[Synonyms]

4-(4-MORPHOLINYLMETHYL)ANILINE
4-(MORPHOLIN-4-YLMETHYL)ANILINE
4-MORPHOLIN-4-YLMETHYL-PHENYLAMINE
4-(MORPHOLINOMETHYL)ANILINE
AKOS BBS-00006785
AKOS MSC-0181
ASISCHEM U94603
BUTTPARK 98\57-95
CHEMBRDG-BB 4011238
TIMTEC-BB SBB010875
4-MORPHOLIN-4-YLMETHYLPHENYLAMINE 95%
[Molecular Formula]

C11H16N2O
[MDL Number]

MFCD03659020
[Molecular Weight]

192.26
[MOL File]

51013-67-3.mol
Chemical PropertiesBack Directory
[Melting point ]

95-97°C
[Boiling point ]

320.7±27.0 °C(Predicted)
[density ]

1.136±0.06 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Inert atmosphere,Room temperature
[pka]

7.26±0.10(Predicted)
[Appearance]

White to light yellow Solid
[CAS DataBase Reference]

51013-67-3(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

Xi,C
[Risk Statements ]

R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R34:Causes burns.
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S22:Do not breathe dust .
[HazardClass ]

IRRITANT
[HS Code ]

2934999090
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Potassium carbonate-->Acetone-->Ammonium chloride-->Iron-->Morpholine-->HEAVY DISTILLATE-->4-Nitrobenzyl bromide-->4-(4-Nitrobenzyl)Morpholine hydrochloride-->4-(4-Nitrobenzyl)morpholine-->Hydrogen
Hazard InformationBack Directory
[Uses]

4-(Morpholinomethyl)aniline is an aniline derivative used in the preparation of tyrosine kinase inhibitors.
[Synthesis]

4-(4-NITROBENZYL)MORPHOLINE

6425-46-3

4-(Morpholinomethyl)aniline

51013-67-3

General procedure for the synthesis of 4-morpholinomethylaniline from 4-(4-nitrobenzyl)morpholine: 4-(4-nitrobenzyl)morpholine (2.22 g, 10 mmol) was dissolved in methanol under nitrogen atmosphere and 200 mg of Pd/C catalyst was added. Hydrogen was then passed through to carry out the hydrogenation reaction, which lasted for 6 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was collected. The filtrate was concentrated to give 1.83 g of 4-morpholinomethylaniline solid in 95% yield.

[References]

[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 12, p. 3507 - 3525
[2] RSC Advances, 2015, vol. 5, # 58, p. 47125 - 47130
[3] Patent: CN106432235, 2017, A. Location in patent: Paragraph 0091; 0092
[4] Organic Process Research and Development, 2006, vol. 10, # 3, p. 493 - 499
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 4, p. 1499 - 1518
Spectrum DetailBack Directory
[Spectrum Detail]

4-(Morpholinomethyl)aniline(51013-67-3)1HNMR
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

4-(morpholinomethyl)aniline(51013-67-3)
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