ChemicalBook--->CAS DataBase List--->24168-96-5

24168-96-5

24168-96-5 Structure

24168-96-5 Structure
IdentificationMore
[Name]

Isoconazole nitrate
[CAS]

24168-96-5
[Synonyms]

1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1h-imidazole mononitrate
ISOCONAZOLE NITRATE
1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1H-imidazolium nitrate
1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-, mononitrate (9CI)
Adestan G 100
Fazol
Gyno-Travogen
Imidazole, 1-[2,4-dichloro-b-[(2,6-dichlorobenzyl)oxy]phenethyl]-, mononitrate (8CI)
R 15454
Travogen
Travogyn
1-(2-(2,4-Dichlorophenyl)-2-((2,6-dichlorophenyl)methoxy)ethyl)-1H-imidazole nitrate
Gyno-travozen
[EINECS(EC#)]

246-051-4
[Molecular Formula]

C18H15Cl4N3O4
[MDL Number]

MFCD01721647
[Molecular Weight]

479.14
[MOL File]

24168-96-5.mol
Chemical PropertiesBack Directory
[Melting point ]

178-182°C
[storage temp. ]

Sealed in dry,2-8°C
[solubility ]

Very slightly soluble in water, soluble in methanol, slightly soluble in ethanol (96 per cent).
[form ]

neat
[color ]

White to Off-White
[Merck ]

14,5160
[CAS DataBase Reference]

24168-96-5(CAS DataBase Reference)
Safety DataBack Directory
[RTECS ]

NI4772000
[HS Code ]

2933.29.4300
Hazard InformationBack Directory
[Chemical Properties]

White Solid
[Originator]

Fazol,Fournier,France,1979
[Uses]

Antibacterial; antifungal
[Uses]

Isoconazole Nitrate acts as an antibacterial in the local treatment of vaginitis; antifungal agent (1,2).
[Manufacturing Process]

To a stirred and refluxing solution of 40 parts of benzene and 35 parts of dimethylformamide (both solvents previously dried azeotropically) are added successively 1.6 parts of sodium hydride and 7.7 parts of α-(2,4- dichlorophenyl)imidazole-1-ethanol, (cooling on ice is necessary). After the addition is complete, stirring and refluxing is continued for 30 minutes. Then there are added 7.8 parts of 2.6-dichlorobenzyl chloride and the whole is stirred at reflux for another 3 hours. The reaction mixture is poured onto water and the product 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl] imidazole, is extracted with benzene. The extract is washed twice with water, dried, filtered and evaporated in vacuo. The base residue is dissolved in a mixture of acetone and diisopropyl ether and to this solution is added an excess of concentrated nitric acid solution. The precipitated nitrate salt is filtered off and recrystallized from a mixture of methanol and diisopropyl ether, yielding 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl]imidazole nitrate; melting point 179°C.
[Therapeutic Function]

Antibacterial, Antifungal
Spectrum DetailBack Directory
[Spectrum Detail]

Isoconazole nitrate(24168-96-5)1HNMR
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