| Identification | More | [Name]
3-Amino-6-morpholinopyridine | [CAS]
52023-68-4 | [Synonyms]
3-AMINO-6-MORPHOLINOPYRIDINE
6-MORPHOLIN-4-YLPYRIDIN-3-AMINE
6-MORPHOLIN-4-YL-PYRIDIN-3-YLAMINE
6-MORPHOLINO-3-PYRIDINAMINE
6-MORPHOLINOPYRIDIN-3-AMINE
AKOS B034244
BUTTPARK 99\12-14
OTAVA-BB BB7018930038
5-Amino-2-morpholin-4-ylpyridine
3-Amino-6-(4-morpholino)pyridine
6-(4-Morpholinyl)-3-pyridinamine
6-Morpholinopyridine-3-amine
3-Amino-6-(4-morpholinyl)pyridine | [EINECS(EC#)]
257-613-3 | [Molecular Formula]
C9H13N3O | [MDL Number]
MFCD00119562 | [Molecular Weight]
179.22 | [MOL File]
52023-68-4.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36/37:Wear suitable protective clothing and gloves . | [RIDADR ]
2811 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
2934999090 |
| Hazard Information | Back Directory | [Uses]
5-Amino-2-(4-morpholinyl)pyridine is used as pharmaceutical intermediate. | [Synthesis]
General procedure for the synthesis of 3-amino-6-morpholinopyridine from 4-(5-nitropyridin-2-yl)morpholine: a mixture of 1.65 g (7.8 mmol) of 4-(5-nitro-2-pyridinyl)morpholine, 160 mg of 5% Pt/C catalyst, and 20 mL of ethanol was placed in a reactor. The reaction was carried out under 50 psi hydrogen atmosphere for 5 hours. Upon completion of the reaction, the mixture was filtered through a pad of diatomaceous earth to remove the catalyst, followed by evaporation of the solvent under reduced pressure to afford 1.4 g (100% yield) of 6-(4-morpholino)-3-pyridinamine, the product being a purple solid. Its 1H NMR (400 MHz, DMSO-d6) data were as follows: δ 7.60 (d, J=2.9 Hz, 1H), 6.92 (dd, J=8.8 and 2.9 Hz, 1H), 6.62 (d, J=8.8 Hz, 1H), 4.59 (brs, 2H), 3.65-3.72 (m, 4H), 3.17 (dt, J= 4.9 and 2.4 Hz, 4H). | [References]
[1] Patent: WO2009/32667, 2009, A1. Location in patent: Page/Page column 148
[2] Patent: WO2009/76140, 2009, A1. Location in patent: Page/Page column 237
[3] Patent: WO2010/104899, 2010, A1. Location in patent: Page/Page column 106
[4] Patent: WO2009/154769, 2009, A1. Location in patent: Page/Page column 35
[5] Patent: WO2014/12360, 2014, A1. Location in patent: Paragraph 00355 |
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