| Identification | More | [Name]
2,3-Dimethoxypyridine | [CAS]
52605-97-7 | [Synonyms]
2,3-DIMETHOXYPYRIDINE
PYRIDINE, 2,3-DIMETHOXY-
2,3-Dimethoxypyridine ,98% | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C7H9NO2 | [MDL Number]
MFCD03095043 | [Molecular Weight]
139.15 | [MOL File]
52605-97-7.mol |
| Chemical Properties | Back Directory | [Appearance]
Yellow Liquid | [Melting point ]
121-122 °C | [Boiling point ]
98-100°C 16mm | [density ]
1,104 g/cm3 | [refractive index ]
1.5205 | [Fp ]
98-100°C/16mm | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Chloroform, Ethyl Acetate | [form ]
Yellow Liquid | [pka]
4.70±0.10(Predicted) | [Detection Methods]
GC,NMR,MS | [BRN ]
1526067 | [CAS DataBase Reference]
52605-97-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37:Wear suitable gloves .
S36/37:Wear suitable protective clothing and gloves . | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Liquid | [Uses]
2,3-Dimethoxypyridine (cas# 52605-97-7) is a compound useful in organic synthesis. | [Synthesis]
To a three-necked flask was added 2-chloro-3-methoxypyridine (5.58 g, 39.0 mmol), N,N-dimethylformamide (60 mL) and sodium methanol (6.20 g, 115.0 mmol). The reaction mixture was stirred at 60 °C overnight. After completion of the reaction, the mixture was cooled to room temperature, water (120 mL) was added and extracted with ethyl acetate (80 mL x 3). The organic phases were combined and washed sequentially with water (100 mL x 2) and saturated brine (100 mL), then dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated by rotary evaporator to give 2,3-dimethoxypyridine (4.0 g, 28.9 mmol, 74% yield) as a yellow liquid. | [References]
[1] Journal of Organic Chemistry, 1994, vol. 59, # 21, p. 6173 - 6178
[2] Patent: CN107286084, 2017, A. Location in patent: Paragraph 0008
[3] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 23, p. 5083 - 5090
[4] Patent: WO2007/123995, 2007, A2. Location in patent: Page/Page column 40-41
[5] Patent: US2008/261919, 2008, A1. Location in patent: Page/Page column 18-19 |
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