| Identification | More | [Name]
Ammonium thioglycolate | [CAS]
5421-46-5 | [Synonyms]
AMMONIUM MERCAPTOACETATE
AMMONIUM THIOGLYCOLATE
AMMONIUM THIOGLYCOLLATE
ATG
MERCAPTOACETIC ACID AMMONIUM SALT
THIOGLYCOLIC ACID AMMONIUM SALT
Aceticacid,mercapto-,monoammoniumsalt
mercapto-aceticacimonoammoniumsalt
thiofacoa-50
thioglycolicacidammoniumsaltsol.
thioglycolicacidammoniumsaltsolution
thioglycollicacid,ammoniumsalt
usafmo-2
Ammonium thioglycolate solution
THIOGLYCOLIC ACID AMMONIUM SALT SOL., ~6 0% IN WATER
AmmoniumMercaptoacetateSolution
ammonium marcaptoacetate
Ammoniumthioglykolat
THIOGLYCOLIC ACID AMMONIUM SALT 60% SOLUTION IN WATER
Ammonium thioglycollate solution | [EINECS(EC#)]
226-540-9 | [Molecular Formula]
C2H7NO2S | [MDL Number]
MFCD00137451 | [Molecular Weight]
109.15 | [MOL File]
5421-46-5.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear colorless solution with characteristic odor | [Melting point ]
139-139.5 °C | [Boiling point ]
115℃[at 101 325 Pa] | [density ]
1.22 | [vapor pressure ]
0.001Pa at 25℃ | [storage temp. ]
2-8°C, stored under nitrogen | [form ]
Solution | [color ]
Clear colorless | [Specific Gravity]
1.245 (25℃) | [Odor]
strong skunk-like odor | [Water Solubility ]
Miscible | [Cosmetics Ingredients Functions]
HAIR WAVING OR STRAIGHTENING
REDUCING
DEPILATORY | [Cosmetic Ingredient Review (CIR)]
Ammonium thioglycolate (5421-46-5) | [InChI]
InChI=1S/C2H4O2S.H3N/c3-2(4)1-5;/h5H,1H2,(H,3,4);1H3 | [Contact allergens]
This substance is contained in “basic” permanent waves
solutions and causes contact dermatitis in hairdressers. | [InChIKey]
JYAVWXRMOOCSOD-UHFFFAOYSA-N | [SMILES]
C([O-])(=O)CS.[NH4+] | [LogP]
-2.99 at 20℃ | [CAS DataBase Reference]
5421-46-5(CAS DataBase Reference) | [EPA Substance Registry System]
5421-46-5(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colorless solution with characteristic odor | [General Description]
Colorless to faint pink liquid with a repulsive, skunk-like odor. | [Reactivity Profile]
AMMONIUM THIOGLYCOLATE(5421-46-5) may be sensitive to heat. This compound is incompatible with acids. | [Air & Water Reactions]
Water soluble. | [Fire Hazard]
Flash point data for this compound are not available. AMMONIUM THIOGLYCOLATE is combustible. | [Description]
Ammonium thioglycolate, also known as perm salt, is the chemical compound with the formula HSCH2CO2NH4. Being the salt of a weak acid and weak base, ammonium thioglycolic acid exists in solution as an equilibrium mixture of the salt itself as well as the free carboxylic acid thioglycolic acid (HSCH2CO2H) and ammonia : HSCH2COO- + NH4+ ? HSCH2COOH + NH3. | [Uses]
acts as a reducing agent in permanent-waving formulations for hair treatment and in shrink-resistant treatment of wool. | [Uses]
Ammonium thioglycolate is contained in permanent
waves solutions and causes contact dermatitis in
hairdressers. | [Uses]
Solutions of various strengths are used for hair waving and for hair removal. | [Definition]
ChEBI: Ammonium thioglycolate is an organic ammonium salt having thioglycolate(1-) as the counterion. Also known as perm salt, it has use in perming hair. It has a role as a reducing agent and an allergen. It contains a thioglycolate(1-). | [Health Hazard]
Exposure to this compound may cause sensitivity dermatitis of scalp or hands, with edema, erythema, subcutaneous lesions, burning of skin, papular rash and itching. It may also cause hypoglycemia. Other symptoms include central nervous system depression, convulsions and dyspnea. | [Flammability and Explosibility]
Notclassified | [Chemical concepts related to perms]
When discussing the chemistry of perms, one should consider two chemical facts. First is the thiol-disulfide equilibrium:
RSH + R'SSR' ? R'SH + RSSR'
where R and R' are organic substituents such as methyl (-CH3), ethyl (-C2H5), or -CH2COO-.
The thiol-disulfide exchange reaction is accelerated by bases such as ammonia, because the base generates some thiolate anion (RS- ), which attacks the disulfide. Thus the ammonia plays multiple roles (and more, see below) in this application.
The second chemical fact is that polar molecules are less volatile than nonpolar ones. So the glycolate substituent makes the thiol nonvolatile and hence non-odorous. An added advantage is that the glycolate confers some solubility in water. One could almost certainly use HSCH3 and ammonia to give a perm, but there would be serious olfactory consequences. | [The actual chemistry of perms]
A solution containing ammonium thioglycolate contains a lot of free ammonia, which swells hair, rendering it permeable. The thioglycolic acid in the perm solution reduces the disulfide cystine bonds in the cortex of the hair. In a sense, the thioglycolate removes crosslinks. After washing, the hair is treated with a mild solution of hydrogen peroxide, which oxidizes the cysteines back to cystine. These new chemical bonds impart the structural rigidity necessary for a successful perm. The rigidification process is akin to the vulcanization of rubber, where commonly polysulfide linkages are used to crosslink the polymer chains. However, not as many disulfide bonds are reformed as there were before the permanent. As a result, the hair is weaker than before the permanent was applied and repeated applications over the same spot may eventually cause strand breakage. |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS06 | [Signal word ]
Danger | [Hazard statements ]
H290-H301-H317 | [Precautionary statements ]
P280-P301+P310+P330-P302+P352 | [Hazard Codes ]
T | [Risk Statements ]
25-43 | [Safety Statements ]
36/37-45-37-24 | [RIDADR ]
2810 | [WGK Germany ]
1
| [RTECS ]
AI7525000
| [TSCA ]
TSCA listed | [REACH Registrations]
Active | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29309090 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Met. Corr. 1
Skin Sens. 1 | [Safety Profile]
Poison by intravenous
and intraperitoneal routes. An allergen; can
cause contact dermatitis. Emits hydrogen
sulfide. See also SULFIDES. When heated
to decomposition it emits very toxic NOx,
SOx, and NH3. | [Hazardous Substances Data]
5421-46-5(Hazardous Substances Data) | [Toxicity]
LD50 ipr-rat: 165 mg/kg JPETAB 97,349,49 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Maya High Purity Chemicals
|
| Telephone: |
+86 (573) 82222445 (0)18006601000 452520369 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15221/0_EN.htm |
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