| Identification | More | [Name]
3-Aminopyrazine-2-carboxylic acid | [CAS]
5424-01-1 | [Synonyms]
3-AMINO-2-PYRAZINECARBOXYLIC ACID
3-AMINOPIPERAZINE-2-CARBOXYLIC ACID
3-AMINOPYRAZINE-2-CARBOXYLIC ACID
TIMTEC-BB SBB004179
3-Aminophrazine-2-carboxylic acid
3-AMINOPYRAZINE-2-CARBOXYLIC ACIDCRYSTAL LINE
3-AMINOPYRAZINE-2-CARBOXYLIC ACID, 99+%
Pyrazinecarboxylic acid, 3-amino-(7CI,8CI,9CI)
3-Aminopyrazine-2-carboxylic acid 98%
3-AMINO-2-PYRAZINECARBOXYLIC ACID, TECHN. 97%
2-Aminopyrazine-3-carboxylic acid
3-Aminopyrazinoic acid | [EINECS(EC#)]
226-558-7 | [Molecular Formula]
C5H5N3O2 | [MDL Number]
MFCD00006141 | [Molecular Weight]
139.11 | [MOL File]
5424-01-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Pale Brown Crystalline Solid | [Melting point ]
205-210 °C (dec.) (lit.) | [Boiling point ]
255.04°C (rough estimate) | [density ]
1.4551 (rough estimate) | [refractive index ]
1.5900 (estimate) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
DMSO (Sparingly) , Methanol (Slightly) | [form ]
Crystalline Powder | [pka]
3.65±0.10(Predicted) | [color ]
Yellow-greenish | [Usage]
Antidiabetic | [Detection Methods]
T,NMR,M.P | [BRN ]
124835 | [InChI]
InChI=1S/C5H5N3O2/c6-4-3(5(9)10)7-1-2-8-4/h1-2H,(H2,6,8)(H,9,10) | [InChIKey]
ZAGZIOYVEIDDJA-UHFFFAOYSA-N | [SMILES]
C1(C(O)=O)=NC=CN=C1N | [LogP]
-3.1 at 20℃ and pH7 | [Surface tension]
73.6mN/m at 1g/L and 20℃ | [CAS DataBase Reference]
5424-01-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [REACH Registrations]
Active | [HS Code ]
29339900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Dam. 1 |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Brown Crystalline Solid | [Uses]
Antidiabetic | [Synthesis]
General procedure for the synthesis of 3-aminopyrazine-2-carboxylic acid from methyl 3-aminopyrazine-2-carboxylate: Methyl 3-aminopyrazine-2-carboxylate (2.08 g, 13.6 mmol) was suspended in methanol (40 mL) under nitrogen protection, and treated with 1N aqueous sodium hydroxide (30 mL). The reaction mixture was warmed up to room temperature and stirred for 50 min. Subsequently, methanol (about 45 mL) was partially evaporated under reduced pressure. The resulting mixture was cooled in an ice water bath and 1N aqueous hydrochloric acid solution (70 mL) was slowly added. Initially the mixture appeared as a solution and gradually a precipitate was generated with further addition of acid. The solid product was collected by filtration, washed with water (3 x 10 mL) and finally dried under vacuum to give 1.48 g of the target product 3-aminopyrazine-2-carboxylic acid. | [References]
[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 7, p. 2320 - 2330
[2] Patent: WO2013/169907, 2013, A1. Location in patent: Page/Page column 44 |
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Alfa Aesar
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Energy Chemical
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Jia Xing Isenchem Co.,Ltd
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