| Identification | More | [Name]
Doxylamine succinate | [CAS]
562-10-7 | [Synonyms]
DOXYLAMINE SUCCINATE
DOXYLAMINE SUCCINATE SALT
LABOTEST-BB LT00244822
N,N-DIMETHYL-2-[1-PHENYL-1-(2-PYRIDINYL)ETHOXY]ETHENAMINE SUCCINATE
2-(alpha-(2-(dimethylamino)ethoxy)-alpha-methylbenzyl)-pyridinsuccinate(1
2-(alpha-(2-dimethylaminoethoxy)-alpha-methylbenzyl)pyridinesuccinate
2-dimethylaminoethoxyphenylmethyl-2-picolinesuccinate
alsadorm
decapryn
decarpynsuccinate(1:1)
dimethylaminoethoxy-methyl-benzyl-pyridinesuccinate
doxylaminesuccinate(1:1)
gittalun
hoggarn
mereprine
phenyl2-pyridylmethyl-beta-n,n-dimethylaminoethylethersuccinate
sedaplus
unisom
Decapryn succinate
DOXYLAMINESUCCINATE,USP | [EINECS(EC#)]
209-228-7 | [Molecular Formula]
C21H28N2O5 | [MDL Number]
MFCD00056168 | [Molecular Weight]
388.46 | [MOL File]
562-10-7.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light cream powder | [Melting point ]
95-98?C | [Fp ]
9℃ | [storage temp. ]
2-8°C | [solubility ]
Very soluble in water, freely soluble in ethanol (96 per cent). | [form ]
neat | [color ]
White to Off-White | [Stability:]
Stable, but may be light sensitive. Incompatible with strong oxidizing agents, acids, bases. | [InChI]
InChI=1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8) | [InChIKey]
KBAUFVUYFNWQFM-UHFFFAOYSA-N | [SMILES]
C(C)(OCCN(C)C)(C1=NC=CC=C1)C1C=CC=CC=1.C(C(=O)O)CC(=O)O | [LogP]
2.519 (est) | [CAS DataBase Reference]
562-10-7(CAS DataBase Reference) | [IARC]
3 (Vol. 79) 2001 | [EPA Substance Registry System]
562-10-7(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves . | [RIDADR ]
UN1230 - class 3 - PG 2 - Methanol, solution | [WGK Germany ]
2
| [RTECS ]
US9275000
| [HS Code ]
2933399090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
STOT SE 3 | [Toxicity]
LD50 in mice, rabbits (mg/kg): 470, 250 orally; 62, 49 i.v.; in mice, male rats, female rats (mg/kg): 460, 440, 445 s.c. (Brown, Werner) |
| Hazard Information | Back Directory | [General Description]
White or creamy white powder. pH (1% aqueous solution) between 4.9 and 5.1. | [Air & Water Reactions]
Water soluble. | [Health Hazard]
SYMPTOMS: Symptoms of exposure to this compound may include drowsiness, excitability, nervousness, dizziness and sleeplessness. | [Fire Hazard]
Flash point data for this chemical are not available. DOXYLAMINE SUCCINATE is probably combustible. | [Chemical Properties]
white to light cream powder | [Uses]
antihistaminic, hypnotic | [Uses]
H1 Histamine receptor antagonist. Antihistaminic; sedative; hypnotic. | [Definition]
ChEBI: Doxylamine succinate is an organic molecular entity. | [Brand name]
Decapryn (Sanofi Aventis); Unisom (Pfizer). | [Biochem/physiol Actions]
H1 histamine receptor antagonist; hypnotic.Doxylamine suppresses histamine at the H1 receptor. It is associated with the short term management of insomnia and temporary relief of common cold symptoms. On the other hand, doxylamine intoxication is linked with rhabdomyolysis and secondary acute renal failure.Studies in mice show that doxylamine induces liver microsomal cytochrome P450 and other enzymes involved in thyroxine (T4) metabolism. In combination with pyridoxine hydrochloride, this drug is used to treat morning sickness. |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Telephone: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
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