| Identification | Back Directory | [Name]
4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone | [CAS]
56632-83-8 | [Synonyms]
2’-Deoxy-2’-fluoro-β-D-arabinocytidine
2'-Deoxy-2'-fluoro-beta-D-arabinocytidine
2'-Fluoro-2'-deoxy-arabinofuranosyl-cytidine
2’-Deoxy-2’-fluoro-beta-D-arabinocytidine, FAC
1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine
FN-008 2'-Fluoro-2'-deoxy-arabinofuranosyl-cytidine
1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosine
1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine HCl
1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine Hydrochloride
4-Amino-1-(2-deoxy-2-fluoro--D-arabinofuranosyl)-2(1H)-pyrimidinone
2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone
4-amino-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
4-AMino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidin-2(1H)-one | [Molecular Formula]
C9H12FN3O4 | [MDL Number]
MFCD07374399 | [MOL File]
56632-83-8.mol | [Molecular Weight]
245.21 |
| Chemical Properties | Back Directory | [Melting point ]
136-138 °C | [Boiling point ]
500.1±60.0 °C(Predicted) | [density ]
1.82±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO: Soluble
Methanol: Soluble | [form ]
Solid | [pka]
12.84±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 4-amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone: 4-amino-1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone (3.60 mmol) was dissolved in saturated ammonia methanol solution (30 mL ) in saturated ammonia methanol solution (30 mL) and the reaction was stirred at room temperature for 15 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure to obtain the crude product. 5.64 (dd, J = 19.44 Hz, 1H, H-3'), 5.26 (d, J = 48.2 Hz, 1H, H-2'), 4.50 (m, 1H, H-4'), 3.70-3.77 (m, 2H, H-5'). | [References]
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
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