| Identification | More | [Name]
7-Hydroxyquinoline | [CAS]
580-20-1 | [Synonyms]
7-HYDROXYQUINOLINE
7-QUINOLINOL
quinolin-7-ol
7-HYDROXYQUINOLINE 99%
1H-Quinolin-7-one | [EINECS(EC#)]
209-457-2 | [Molecular Formula]
C9H7NO | [MDL Number]
MFCD00016730 | [Molecular Weight]
145.16 | [MOL File]
580-20-1.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powder | [Melting point ]
239-244 °C | [Boiling point ]
264.27°C (rough estimate) | [density ]
1.1555 (rough estimate) | [refractive index ]
1.4500 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Powder | [pka]
pK1:5.48(＋1);pK2:8.85(0) (20°C) | [color ]
Beige to pale brown | [Water Solubility ]
454.3mg/L(20 ºC) | [Detection Methods]
HPLC | [InChI]
InChI=1S/C9H7NO/c11-8-4-3-7-2-1-5-10-9(7)6-8/h1-6,11H | [InChIKey]
XCRPPAPDRUBKRJ-UHFFFAOYSA-N | [SMILES]
N1C2C(=CC=C(O)C=2)C=CC=1 | [CAS DataBase Reference]
580-20-1(CAS DataBase Reference) | [NIST Chemistry Reference]
7-Quinolinol(580-20-1) | [Storage Precautions]
Store under nitrogen;Heat sensitive;Light sensitive;Air sensitive | [EPA Substance Registry System]
580-20-1(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319 | [Precautionary statements ]
P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
WGK 3 | [RTECS ]
VC4160000 | [TSCA ]
TSCA listed | [HazardClass ]
IRRITANT | [HS Code ]
29334900 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powder | [Uses]
7-Hydroxyquinoline is an amphoteric molecule containing both acidic hydroxyl and basic nitrogen moieties, exhibiting a solvent-dependent equilibrium between enol and keto/zwitterion tautomers[2][3]. The compound serves as a local reporter for examining drug-binding sites in human serum albumin and for measuring fluorescence spectra in ionic liquids such as [bmim][Tf2N] and [bmim][PF6] with varying methanol concentrations[2][3]. | [Definition]
ChEBI: A monohydroxyquinoline carrying a hydroxy substituent at position 7. | [Synthesis]
The general procedure for the synthesis of 7-hydroxyquinoline from acrolein diethyl acetal and 3-aminophenol was as follows: the reaction was carried out in a Panasonic NN-K5541JF microwave reactor equipped with a magnetic stirring device. The typical operation was as follows: acrolein diethyl acetal (1 mmol), excess 3-aminophenol (4 mmol) and solid catalyst were added to a round bottom flask; subsequently, the mixture was placed in a microwave reactor. The reaction was carried out by continuous microwave radiation under reflux and stirring conditions for 1 to 40 min. Upon completion of the reaction, the products were analyzed and identified using a Varian Saturn 2200/CP-3800 gas chromatography-mass spectrometer (GC-MS) equipped with two CP8944 capillary columns (VF-5, 30 m × 0.25 mm × 0.25 μm). | [References]
[1] Catalysis Communications, 2018, vol. 115, p. 21 - 25 |
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J & K SCIENTIFIC LTD.
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https://www.jkchemical.com |
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Energy Chemical
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Jia Xing Isenchem Co.,Ltd
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Maya High Purity Chemicals
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