| Identification | More | [Name]
Tyramine hydrochloride | [CAS]
60-19-5 | [Synonyms]
2-(3-INDOLYL)ETHYLAMINE HYDROCHLORIDE
3-(2-AMINOETHYL)INDOLE HCL
3-(2-AMINOETHYL)INDOLE HYDROCHLORIDE
TIMTEC-BB SBB000359
TRYPTAMINE HCL
TRYPTAMINE HYDROCHLORIDE
4-(2-aminoethyl)-phenohydrochloride
p-(2-aminoethyl)-phenomonohydrochloride
Phenol,4-(2-aminoethyl)-,hydrochloride
p-tryaminehydrochloride
tyraminemonochloride
4-hydroxyphenethylammonium chloride
4-HYDROXYPHENETHYLAMINE HYDROCHLORIDE (T YRAMINE HCL) DOPA
TYRAMINE HYDROCHLORIDE 99%
P-HYDROXYPHENETHYLAMINE HCL
P-HydroxyphenylEthylamineHydrochloride
Tyraminehydrochloride,98%
2-(4-Hydroxyphenyl)ethanamine
2-p-Hydroxyphenethylamine hydrochloride
Mydrial | [EINECS(EC#)]
206-446-4 | [Molecular Formula]
C8H12ClNO | [MDL Number]
MFCD00012682 | [Molecular Weight]
173.64 | [MOL File]
60-19-5.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-White to Light Yellow Powder | [Melting point ]
253-255 °C(lit.) | [Boiling point ]
269°C/760mmHg | [storage temp. ]
Store at RT. | [solubility ]
H2O: soluble50 mg/ml, clear, colorless to faintly yellow | [form ]
Crystalline Powder | [color ]
White to almost white | [PH]
<7 (H2O) | [Water Solubility ]
H2O: soluble 50 mg/ml, clear, colorless to faintly yellow | [Sensitive ]
Hygroscopic | [Usage]
Adrenergic | [Merck ]
14,9835 | [BRN ]
3627058 | [Stability:]
Hygroscopic | [Cosmetics Ingredients Functions]
ANTIOXIDANT
SKIN CONDITIONING - MISCELLANEOUS | [InChI]
1S/C8H11NO.ClH/c9-6-5-7-1-3-8(10)4-2-7;/h1-4,10H,5-6,9H2;1H | [InChIKey]
RNISDHSYKZAWOK-UHFFFAOYSA-N | [SMILES]
Cl[H].NCCc1ccc(O)cc1 | [LogP]
0.722 (est) | [CAS DataBase Reference]
60-19-5(CAS DataBase Reference) | [EPA Substance Registry System]
60-19-5(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White to Light Yellow Powder | [Occurrence]
Tyramine was originally a compound isolated from ergot alkaloids and decaying animal tissue. It has pharmacological effects such as increasing blood pressure and exciting the uterus. | [Uses]
A naturally occurring monoamine derived from tyrosine. | [Uses]
Adrenergic | [Uses]
Tyramine Hydrochloride is a naturally occurring monoamine derived from tyrosine. Neurotransmitter. | [Application]
Tyramine hydrochloride (T-HCl) is a kind of fluorogenic substrate of peroxidase. It is a naturally occurring monoamine derived from tyrosine. Tyramine Hydrochloride has been used:
coinfused with adenosine in control subjects and patients in order to reduce leg blood flow by 50% without affecting arterial blood pressure.
labelled with fluorescence dyes (Atto 488 and Atto 655) to serve as a substrate for peroxidase in immunofluorescence analysis.
used in dimethylformamide, labelled with 5-(and-6)carboxyfluorescein, succinimidyl ester/biotin to serve as a substrate for peroxidase in tyramide signal amplification.
Neurotransmitter. | [Hazard]
Tyramine hydrochloride can cause eye irritation and damage in some persons.It also can cause inflammation of the skin oncontact in some persons.Long-term exposure to respiratory irritants may result in disease of the airways involving difficult breathing and related systemic problems.Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis.
| [Biochem/physiol Actions]
Tyramine is a biogenic amine and a neuromodulator localized to the nervous system. Tyrosine decarboxylase catalysis the formation of tyramine from tyrosine. Tyramine is found to be associated with a number of psychiatric disorders. Tyramine ingestion depletes serotonin, epinephrine and norepinephrine reserves. This results in elevated biological events such as cardiovascular function, blood pressure, glucose production and overall metabolism. It also causes depression, migraine and insomnia. Tyramine is present is several food sources. The process of food fermentation and spoilage increases its tyramine content. | [Synthesis]
Tyramine [2-(p-hydroxyphenyl) ethylamine], a significant metabolite of tyrosine, enzymatic synthesis of tyramine was established by two-step biocatalytic reaction (Scheme 1). Firstly, l-tyrosine was prepared from raw pyruvate fermentation broth under the catalysis of TPL. Pyruvate fermentation broth was simply centrifuged, and then the supernatant was diluted and used as substrate to produce l-tyrosine. Secondly, l-tyrosine was collected as starting material to synthesize tyramine by immobilized TDC cells from Lactobacillus brevis. Pyridoxal phosphate was the common coenzyme for these two enzymes. | [Purification Methods]
Crystallise the hydrochloride from EtOH by addition of diethyl ether, or from conc HCl. [Beilstein 3 II 355.] |
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