| Identification | More | [Name]
ETHYLMALONIC ACID | [CAS]
601-75-2 | [Synonyms]
2-CARBOXY BUTYRIC ACID
ETHYLMALONIC ACID
RARECHEM DK HD C012
1,1-Propanedicarboxylic acid
2-Ethylmalonic acid
alpha-Carboxybutyric acid
Malonic acid, ethyl-
Propanedioic acid, ethyl-
Ethyl propoinic acid
Ethylmalonicacid,98%
2-ethylpropanedioic acid
Ethylpropanedioic acid. | [EINECS(EC#)]
210-007-2 | [Molecular Formula]
C5H8O4 | [MDL Number]
MFCD00002668 | [Molecular Weight]
132.11 | [MOL File]
601-75-2.mol |
| Chemical Properties | Back Directory | [Appearance]
white to faintly pink crystalline powder | [Melting point ]
112-114 °C (lit.) | [Boiling point ]
292.77°C (rough estimate) | [density ]
1.5633 (rough estimate) | [refractive index ]
1.4016 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
pK1:2.90(0);pK2:5.55(+1) (25°C) | [color ]
Off-White | [Water Solubility ]
Soluble in water, methanol (very faint turbidity), and ethanol. | [BRN ]
774334 | [CAS DataBase Reference]
601-75-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Ethylmalonic acid(601-75-2) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HS Code ]
29171990 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Hydrochloric acid-->Water-->Diethyl ethylmalonate-->Ethyl potassium malonate | [Preparation Products]
3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol-->3-[1,1'-Biphenyl]-4-yl-1,2,3,4-tetrahydro-1-naphthol-->2-ETHYLACRYLIC ACID 98-->Ethylmalonic acid dibutyl ester-->Benzenepropanoic acid, β-amino-3,5-dichloro-, ethyl ester |
| Hazard Information | Back Directory | [Chemical Properties]
white to faintly pink crystalline powder | [Uses]
Ethylmalonic acid is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field. | [Definition]
ChEBI: Ethylmalonic acid is a dicarboxylic acid obtained by substitution of one of the methylene hydrogens of malonic acid by an ethyl group. It has a role as a human metabolite. It is a dicarboxylic acid and a dicarboxylic fatty acid. It is functionally related to a malonic acid. It is a conjugate acid of an ethylmalonate and an ethylmalonate(2-). | [Synthesis]
Step 2: In a 250 mL three-necked flask equipped with a magnetic stirrer, a dosing funnel and a thermometer, monoethyl malonate potassium salt (17.77 g, 104.49 mmol) was dissolved in 18 mL of water. The reaction mixture was cooled in an ice bath and 8 mL of concentrated hydrochloric acid (about 2 mL) was added slowly and dropwise. Upon completion of the reaction, the mixture was filtered to remove the resulting KCl precipitate and the precipitate was washed with ether (3 x 50 mL). The filtrate was separated and the aqueous phase was further extracted with ether (3 x 50 mL). All ether phases were combined, dried with anhydrous MgSO4, filtered and concentrated under reduced pressure to give the colorless oily product ethylmalonic acid (13.45 g, 82% overall yield in two steps). | [IC 50]
Human Endogenous Metabolite | [storage]
Store at -20°C | [References]
[1] Patent: US6780887, 2004, B1 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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