ChemicalBook--->CAS DataBase List--->61270-78-8

61270-78-8

61270-78-8 Structure

61270-78-8 Structure
IdentificationMore
[Name]

Cefonicid sodium
[CAS]

61270-78-8
[Synonyms]

5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-[(HYDROXYPHENYLACETYL)AMINO]-8-OXO-3-[[[1-(SULFOMETHYL)-1H-TETRAZOL-5-YL]THIO]METHYL]-, DISODIUM SALT
CEFONICID DISODIUM
CEFONICID SODIUM
disodium (6r,7r)-7-[[(2r)-2-hydroxy-2-phenyl-acetyl]amino]-8-oxo-3-[[1-(sulfonatomethyl)tetrazol-5-yl]sulfanylmethyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
CEFONICID SODIUM[5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-[(HYDROXYPHENYLACETYL)AMINO]-8-OXO-3-[[[1-(SULFOMETHYL)-1H-TETRAZOL-5-YL]THIO]METHYL]-, DISODIUM SALT]
CEFONICID DISODIUM SALT
CefonicidDisodiumC18H16N6Na2O8S3
CefonicidSodium(Sterile)
Disodium (6R,7R)-7-[[(2R)-2-hydroxy-2-phenyl-acetyl]amino]-8-oxo-3-[[1-(sulfonatomethyl)tetrazol-5-yl]sulfanylmethyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
(6R,7R)-7α-[[(R)-Hydroxyphenylacetyl]amino]-8-oxo-3-[[[1-(sodiooxysulfonylmethyl)-1H-tetrazol-5-yl]thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
SKF D-75073-Z2
[EINECS(EC#)]

612-109-6
[Molecular Formula]

C18H16N6Na2O8S3
[MDL Number]

MFCD00941437
[Molecular Weight]

586.53
[MOL File]

61270-78-8.mol
Chemical PropertiesBack Directory
[Appearance]

White Powder
[Melting point ]

> 160°C
[storage temp. ]

Store at 0-5°C
[solubility ]

DMSO (Slightly), Methanol (Slightly)
[form ]

Solid
[color ]

White to Pale Yellow
[CAS DataBase Reference]

61270-78-8(CAS DataBase Reference)
Safety DataBack Directory
[HS Code ]

2941906000
Hazard InformationBack Directory
[Description]

Cefonicid sodium is the first of the second-generation cephalosporin antibiotics with a long enough serum half-life b4.5 hr.) to allow once-daily i.v. administration. Cefonicid is resistant to β-lactamases produced by S. aureus, H. influenzae, -N. gonorrhea, and related organisms. As with other drugs of this class, it is useful in the treatment of urinary tract and lower respiratory tract infections, skin and skin structure infections, and bone and joint infections, as well as in surgical prophylaxis.
[Chemical Properties]

White Powder
[Originator]

Smith Kline & French (USA)
[Uses]

A semi-synthetic cephalosporin antibiotic related to Cefamandole. Antibacterial.
[Definition]

ChEBI: Cefonicid sodium is an organic sodium salt. It contains a cefonicid(2-).
[Brand name]

MONOCID
[Clinical Use]

Cefonicid Sodium (Monocid) is a second-generationcephalosporin that is structurally similar to cefamandole,except that it contains a methane sulfonic acid groupattached to the N-1 position of the tetrazole ring. Theantimicrobial spectrum and limited β-lactamase stabilityof cefonicid are essentially identical with those ofcefamandole.
Cefonicid is unique among the second-generationcephalosporins in that it has an unusually long serum halflifeof approximately 4.5 hours. High plasma protein bindingcoupled with slow renal tubular secretion are apparentlyresponsible for the long duration of action. Despite the high fraction of drug bound in plasma, cefonicid is distributedthroughout body fluids and tissues, with the exception of thecerebrospinal fluid.
Cefonicid is supplied as a highly water-soluble disodiumsalt, in the form of a sterile powder to be reconstituted forinjection. Solutions are stable for 24 hours at 25°C and for72 hours when refrigerated.
[in vitro]

cefonicid was found to be similar to cefamandole in its superiority to first generation cephalosporins against several enterobacteriaceae and haemophilus influenzae, such as beta-lactamase-producing strains. its activity against staphylococcus aureus was similar to that of cefoxitin and inferior to cefamandole and first generation cephalosporins. cefonicid has excellent in-vitro activity against neisseria gonorrhoeae, but is inactive against pseudomonas, serratia, acinetobacter, and bacteroides fragilis [1].
[in vivo]

the purpose of a previous study was to determine whether cefonicid caused testicular toxicity when subcutaneously administered to sprague-dawley male rats at doses of 50 to 1,000 mg/kg per day. the histological findings were confirmed by marked reductions in testicular sperm production rates and cauda epididymal sperm numbers. in addition, cefonicid had no treatment-related adverse effects on the sexual maturation males [2].
[References]

[1] saltiel, e; brogden, r. n. (1986). cefonicid. a review of its antibacterial activity, pharmacological properties and therapeutic use. drugs. 32 (3): 222–59.
[2] manson jm, zolna le, kang yj, johnson cm. effects of cefonicid and other cephalosporin antibiotics on male sexual development in rats. antimicrob agents chemother. 1987 jul;31(7):991-7.
Spectrum DetailBack Directory
[Spectrum Detail]

Cefonicid sodium(61270-78-8)1HNMR
61270-78-8 suppliers list
Company Name: Hebei Jingbo New Material Technology Co., Ltd
Tel: +8619931165850 , +8619931165850
Website: www.hbjingbo.cn
Company Name: Hebei Saisier Technology Co., LTD
Tel: +86-18400010335 +86-18034520335 , +86-18034520335
Website: www.hbsaisier.cn
Company Name: Hebei Longbang Technology Co., LTD
Tel: +86-18032476855 +86-18032476855 , +86-18032476855
Website: www.hblongbang.com/
Company Name: HebeiShuoshengImportandExportco.,Ltd
Tel: +86-18532138899 +86-18532138899 , +86-18532138899
Website: www.shuoshengchem.cn
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com/
Company Name: Xiamen AmoyChem Co., Ltd
Tel: +86-592-6051114 +8618959220845 , +8618959220845
Website: http://www.amoychem.com/
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-6139-8061 +86-86-13650506873 , +86-86-13650506873
Website: http://www.chemdad.com/
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427 , +8618523575427
Website: http://www.conier.com/
Company Name: SIMAGCHEM CORP
Tel: +86-13806087780 , +86-13806087780
Website: http://www.simagchem.com/
Company Name: Hebei Runbin Biotechnology Co. LTD
Tel: 13180553332 , 13180553332
Website: runbin.web.aa5.com.cn/vip_runbin.html
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: Longyan Tianhua Biological Technology Co., Ltd
Tel: 0086 18039857276 18039857276 , 18039857276
Website: tianhuaapi.en.alibaba.com
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: +86-0551-65418671 +8618949823763 , +8618949823763
Website: www.tnjchem.com
Company Name: Hebei Henghe Import and Export Trading Co. LTD
Tel: +8618032935937 18032916000 , 18032916000
Website: www.chemicalbook.com/ShowSupplierProductsList1232494/0.htm
Company Name: ANHUI WITOP BIOTECH CO., LTD
Tel: +8615255079626 , +8615255079626
Website: www.chemicalbook.com/showsupplierproductslist418627/0_en.htm
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-029-89586680 +86-18192503167 , +86-18192503167
Website: www.dideu.com
Company Name: AFINE CHEMICALS LIMITED
Tel: +86-0571-85134551
Website: www.afinechem.com/index.html
Company Name: Dayang Chem (Hangzhou) Co.,Ltd.
Tel: 571-88938639 +8617705817739 , +8617705817739
Website: https://www.dycnchem.com/
Tags:61270-78-8 Related Product Information
103-90-2 68-04-2 7601-54-9 7647-14-5 532-32-1 60-35-5 9005-38-3 75-36-5 1914-99-4 123-54-6 127-09-3 62-55-5 144-55-8 67146-22-9 15307-79-6 139-33-3 127-19-5 1310-73-2