| Identification | More | [Name]
5-Hydroxyisophthalic acid | [CAS]
618-83-7 | [Synonyms]
5-HIPA
5-HYDROXY-1,3-BENZENEDICARBOXYLIC ACID
5-HYDROXYBENZENE-1,3-DICARBOXYLIC ACID
5-HYDROXYISOPHTHALIC ACID
5-HYDROXYISOPTHALIC ACID
HYDROXYISOPHTHALIC-5 ACID
HYDROXYISOPHTHALIC ACID, 5-
OHIPA
5-hydroxy-3-benzenedicarboxylicacid
5-hydroxy-isophthalicaci
sym-Hydroxy-iso-phthalicacid
5-Hydroxy-m-phthalic acid
5-Hydroxy-1,3-benzenedicarboxy
5-Hydroxy isophtalic acid
5-HYDROXYISOPHTHHALIC ACID
5-Hydroxy Isophthalate
3,5-Dicarboxyphenol | [EINECS(EC#)]
210-565-7 | [Molecular Formula]
C8H6O5 | [MDL Number]
MFCD00002515 | [Molecular Weight]
182.13 | [MOL File]
618-83-7.mol |
| Chemical Properties | Back Directory | [Appearance]
white to slightly yellow powder | [Melting point ]
298-302 °C (lit.) | [Boiling point ]
235.5°C (rough estimate) | [density ]
1.3293 (rough estimate) | [vapor pressure ]
0Pa at 25℃ | [refractive index ]
1.4330 (estimate) | [storage temp. ]
Store below +30°C. | [solubility ]
0.6g/l | [form ]
Powder | [pka]
3.41±0.10(Predicted) | [color ]
White to slightly yellow | [PH]
<7 (H2O, 20℃) | [Water Solubility ]
0.6g/L(15 ºC) | [BRN ]
2693561 | [InChI]
1S/C8H6O5/c9-6-2-4(7(10)11)1-5(3-6)8(12)13/h1-3,9H,(H,10,11)(H,12,13) | [InChIKey]
QNVNLUSHGRBCLO-UHFFFAOYSA-N | [Dissociation constant]
0-0 at 23℃ | [CAS DataBase Reference]
618-83-7(CAS DataBase Reference) | [EPA Substance Registry System]
618-83-7(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing . | [WGK Germany ]
2
| [RTECS ]
CZ4280000
| [TSCA ]
Yes | [HS Code ]
29182990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
white to slightly yellow powder | [Uses]
5-Hydroxyisophthalic Acid is used as a reagent in the synthesis of silver carboxylate metal organic framework (MOF) complexes. 5-Hydroxyisophthalic Acid is also used as the starting material in the synthesis of N,NтАЩ-Bis(2,3-dihydroxypropyl)-5-[(N-(2-hydroxyethyl)carbamoyl)methoxy]-2,4,6-triiodoisophthalamide (B426310); a compound related to Ioversol( I737000) which is a nonionic, low osmolality, radiographic contrast agent. | [General Description]
The hydrothermal reaction of 5-hydroxyisophthalic acid, Co(II)/Cu(II) and dipyridophenazine, that forms two 3D chiral coordination polymers, was studied. | [Synthesis]
The general procedure for the synthesis of 5-hydroxyisophthalic acid from dimethyl 5-hydroxyisophthalate was as follows: dimethyl 5-hydroxyisophthalate (40 g, 19.03 mmol) was dissolved in THF (10 mL), followed by the addition of aqueous lithium hydroxide (20 mL, 2 M). The reaction mixture was stirred at 40 °C overnight. Upon completion of the reaction, THF was removed by distillation under reduced pressure. the pH of the remaining aqueous solution was adjusted to about 2 with 6N hydrochloric acid to precipitate the product. The precipitated 5-hydroxyisophthalic acid was collected by filtration and dried in a vacuum oven to give 20 g of white solid product in 58% yield. | [References]
[1] Patent: WO2010/78449, 2010, A2. Location in patent: Page/Page column 317 |
|
|