| Identification | More | [Name]
Methyl 3-methoxysalicylate | [CAS]
6342-70-7 | [Synonyms]
2-HYDROXY-3-METHOXYBENZOIC ACID METHYL ESTER
AKOS 214-56
METHYL 2-HYDROXY-3-METHOXY-BENZOATE
METHYL 3-METHOXYSALICYLATE
RARECHEM AL BF 0033 | [EINECS(EC#)]
228-737-5 | [Molecular Formula]
C9H10O4 | [MDL Number]
MFCD00239511 | [Molecular Weight]
182.17 | [MOL File]
6342-70-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
65-68 °C (lit.) | [Boiling point ]
105 °C(Press: 2 Torr) | [density ]
1.216±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
9.76±0.10(Predicted) | [color ]
White to Gray to Red | [λmax]
320nm(Dioxane)(lit.) | [InChI]
InChI=1S/C9H10O4/c1-12-7-5-3-4-6(8(7)10)9(11)13-2/h3-5,10H,1-2H3 | [InChIKey]
BWRCJLJJIXYLNV-UHFFFAOYSA-N | [SMILES]
C(OC)(=O)C1=CC=CC(OC)=C1O | [CAS DataBase Reference]
6342-70-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HS Code ]
29189900 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of methyl 2-hydroxy-3-methoxybenzoate from methanol and 3-methoxysalicylic acid: 25.5 g (0.152 mol) of 3-methoxysalicylic acid was added to 250 ml of methanol containing 1 ml of concentrated sulfuric acid. The reaction mixture was heated to reflux for 4 days. After completion of the reaction, the mixture was concentrated to dryness. The concentrate was extracted with ethyl acetate. The organic layer was washed sequentially with water, 10% sodium carbonate solution, water and saturated sodium chloride solution. After the above treatment, 25.2 g of the target product methyl 2-hydroxy-3-methoxybenzoate was obtained in 91.2% yield. The melting point was 68-69°C. | [References]
[1] Bioorganic and Medicinal Chemistry, 1998, vol. 6, # 9, p. 1447 - 1456
[2] Patent: KR2018/56603, 2018, A. Location in patent: Paragraph 0441; 0453-0455
[3] Australian Journal of Chemistry, 2003, vol. 56, # 11, p. 1099 - 1106
[4] Synthetic Communications, 1995, vol. 25, # 6, p. 915 - 920
[5] Journal of Medicinal Chemistry, 1991, vol. 34, # 5, p. 1612 - 1624 |
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