| Identification | More | [Name]
Iodoacetic acid | [CAS]
64-69-7 | [Synonyms]
IODOACETIC ACID
IODOACETIC ACID MONO
MONOIODOACETIC ACID
RARECHEM AL BO 0101
VITAS-BB TBB000669
Aceticacid,iodo-
CH2ICOOH
IA
iodoacetate
iodoacetic
iodo-aceticaci
Kyselina jodoctova
kyselinajodoctova
monoiodoacetate
IODOACETIC ACID FREE ACID APPROX 99%,*YE LLOW POWDER
IODOACETIC ACID APPROX. 99% WHITE TO OFF
IODOACETIC ACID R. G.
IodoaceticAcid>99%
IodoaceticAcid97%
IODOACETICACID,REAGENT | [EINECS(EC#)]
200-590-1 | [Molecular Formula]
C2H3IO2 | [MDL Number]
MFCD00002685 | [Molecular Weight]
185.95 | [MOL File]
64-69-7.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystalline powder | [Melting point ]
79 °C | [Boiling point ]
208°C | [density ]
2.2003 (estimate) | [Fp ]
208°C | [storage temp. ]
2-8°C
| [solubility ]
H2O: soluble, clear to hazy | [form ]
Liquid | [pka]
3.12(at 25℃) | [color ]
faintly yellow
| [Stability:]
Stable. Incompatible with strong oxidizing agents, bases, strong reducing agents. Store at-20 C. | [biological source]
synthetic | [Water Solubility ]
600 g/L (20 ºC) | [Sensitive ]
Light Sensitive | [Merck ]
14,5025 | [BRN ]
1739079 | [InChI]
1S/C2H3IO2/c3-1-2(4)5/h1H2,(H,4,5) | [InChIKey]
JDNTWHVOXJZDSN-UHFFFAOYSA-N | [SMILES]
OC(=O)CI | [CAS DataBase Reference]
64-69-7(CAS DataBase Reference) | [NIST Chemistry Reference]
Acetic acid, iodo-(64-69-7) | [EPA Substance Registry System]
64-69-7(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS06 | [Signal word ]
Danger | [Hazard statements ]
H301-H314 | [Precautionary statements ]
P260-P280-P301+P310+P330-P303+P361+P353-P305+P351+P338+P310 | [Hazard Codes ]
T,C | [Risk Statements ]
R25:Toxic if swallowed.
R35:Causes severe burns. | [Safety Statements ]
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2923 8/PG 1
| [WGK Germany ]
1
| [RTECS ]
AI3500000
| [F ]
8-9 | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29159080 | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 3 Oral
Eye Dam. 1
Skin Corr. 1A | [Hazardous Substances Data]
64-69-7(Hazardous Substances Data) | [Toxicity]
LD50 intravenous in dog: 45mg/kg |
| Hazard Information | Back Directory | [General Description]
Colorless or white crystals. | [Reactivity Profile]
IODOACETIC ACID(64-69-7) reacts vigorously with bases and is corrosive. | [Air & Water Reactions]
May be sensitive to heat, light, and air. Water soluble | [Fire Hazard]
Flash point data for this chemical are not available, but IODOACETIC ACID is probably non-flammable. | [Chemical Properties]
white to light yellow crystalline powder | [Uses]
Used as a general reagent in acylation reactions. A byproduct formed in treated waters, and found in marine life. | [Definition]
ChEBI: A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom. | [Biochem/physiol Actions]
Iodoacetic acid (IAA) blocks the thiol group of cysteine. IAA inhibits glyceraldehyde-3-phosphate dehydrogenase (G3PDH) by interacting with sulfhydryl group of the active site cysteine. IAA inhibits the progression of solid Ehrlich carcinoma. IAA is one of the iodinated disinfection byproducts in drinking water. It is cytotoxic to mammalian cells. | [Purification Methods]
Crystallise it from pet ether (b 60-80o) or CHCl3/CCl4. [Beilstein 2 IV 534.] |
|
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