| Identification | More | [Name]
Ethyl 2-oxo-4-phenylbutyrate | [CAS]
64920-29-2 | [Synonyms]
2-OXO-4-PHENYLBUTANOIC ACID ETHYL ESTER
2-OXO-4-PHENYLBUTYRIC ACID ETHYL ESTER
4-PHENYL-2-OXOBUTYRIC ACID ETHYL ESTER
BENZYLPYRUVIC ACID ETHYL ESTER
ETHYL-2 OXO-4 PHENYL BUTANOATE
ETHYL 2-OXO-4-PHENYLBUTYRATE
ETHYL BENZYLPYRUVATE
KETO ESTER
Benzenebutanoicacid,.alpha.-oxo-,ethylester
ETHYL-2-OXO-4-PHENYLBUTRATE
Ethyl 2-oxo-phenylbutrate (EOPB)
Benzenebutanoic acid, a-oxo-, ethyl ester
Ethyl 2-oxo-4-phenylbutyrate, 90+%
α-Oxobenzenebutanoic acid ethyl ester
α-Oxobenzenebutyric acid ethyl ester
Ethy 2-oxo-4-phenylbutyrate | [EINECS(EC#)]
265-276-9 | [Molecular Formula]
C12H14O3 | [MDL Number]
MFCD00037533 | [Molecular Weight]
206.24 | [MOL File]
64920-29-2.mol |
| Chemical Properties | Back Directory | [Boiling point ]
132 °C/2 mmHg (lit.) | [density ]
1.091 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.504(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly) | [form ]
Oil | [color ]
Colourless | [BRN ]
2725083 | [InChI]
InChI=1S/C12H14O3/c1-2-15-12(14)11(13)9-8-10-6-4-3-5-7-10/h3-7H,2,8-9H2,1H3 | [InChIKey]
STPXIOGYOLJXMZ-UHFFFAOYSA-N | [SMILES]
C(C1C=CC=CC=1)CC(=O)C(=O)OCC | [CAS DataBase Reference]
64920-29-2(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [synthesis]
Potassium tert-butoxide (4.3 g, 38.34 mmol) was added in 1 portion to a solution of the diester (8 g, 25.56 mmol) in toluene (80 mL) at 0 °C. After being stirred at the same temperature for 30 min, the reaction mixture was kept at room temperature overnight. Water (100 mL) was added, the phases were separated, and the aqueous phase was extracted with EtOAc (3 × 100 mL). The combined organic extracts were dried and evaporated. The residue was purifified by flflash chromatography eluting with EtOAc:light petroleum (1:9) to give 5.6 g (78%) of the keto-ester as an orange oil. |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24/25:Avoid contact with skin and eyes .
S36/37:Wear suitable protective clothing and gloves .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [REACH Registrations]
Active | [Storage Class]
10 - Combustible liquids |
| Hazard Information | Back Directory | [Chemical Properties]
light yellow oily liquid | [Uses]
Ethyl 2-oxo-4-phenylbutyrate may be used in the synthesis of ethyl (R)-2-hydroxy-4-phenylbutyrate, an important chiral precursor for angiotensin-converting enzyme (ACE) inhibitor. | [General Description]
Ethyl 2-oxo-4-phenylbutyrate is an aliphatic α-ketoester. Bioreduction of ethyl 2-oxo-4-phenylbutyrate is reported to yield ethyl (R)-2-hydroxy-4-phenylbutanoate. The effect of ionic liquid on the asymmetric reduction of ethyl 2-oxo-4-phenylbutyrate by Saccharomyces cerevisiae has been reported. Asymmetric reduction of ethyl 2-oxo-4-phenylbutyrate using a bacterial reductase is reported. Enantioselective hydrogenation of ethyl 2-oxo-4-phenylbutyrate using homogeneous Rh-diphosphine and heterogeneous Pt/Al2O3-cinchona catalysts has been reported. |
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| Company Name: |
Henan yingchuang Gold
|
| Telephone: |
16650708709 |
| Website: |
www.hnyingchuang.com/ |
| Company Name: |
J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
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