| Identification | More | [Name]
2-Chloro-1,3,2-dioxaphospholane-2-oxide | [CAS]
6609-64-9 | [Synonyms]
2-CHLORO-1,3,2-DIOXAPHOSPHOLANE-2-OXIDE
2-CHLORO-2-OXO-1,3,2-DIOXAPHOSPHOLANE
ETHYLENE CHLOROPHOSPHATE
ETHYLENE CYCL-CHLOROPHOSPHATE
2-Chloro-1,2,3-dioxaphospholane-2-oxide
Ethylene cycl-chlorophosphate (2-chloro-2-oxo-1,3,2-dioxaphospholane)
Ethylene chlorophosphate, tech. 90%
2-Chloro-2-oxo-1,3,2-dioxaphospholane, Ethylene cycl-chlorophosphate
2-Chloro-1,3,2-dioxaphospholane-2-oxide, Ethylene cycl-chlorophosphate
1,3,2-Dioxaphospholane, 2-chloro-, 2-oxide
2-Chloro-1,3-dioxa-2-phosphacyclopentane 2-oxide | [EINECS(EC#)]
229-560-6 | [Molecular Formula]
C2H4ClO3P | [MDL Number]
MFCD00043138 | [Molecular Weight]
142.48 | [MOL File]
6609-64-9.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colourless liquid | [Melting point ]
12-14 °C
| [Boiling point ]
89-91 °C0.8 mm Hg(lit.)
| [density ]
1.55 g/mL at 25 °C(lit.)
| [vapor pressure ]
1.06hPa at 25℃ | [refractive index ]
n20/D 1.45(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
−20°C
| [solubility ]
Chloroform (Soluble), Ethyl Acetate (Slightly) | [form ]
Solid or Film | [color ]
White to off-white or clear | [Water Solubility ]
Miscible with water and chloroform. | [Sensitive ]
Moisture Sensitive | [BRN ]
606582 | [Stability:]
Extremely moisture sensitive | [InChIKey]
SBMUNILHNJLMBF-UHFFFAOYSA-N | [LogP]
-0.485 at 25℃ and pH7 | [CAS DataBase Reference]
6609-64-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS05 | [Signal word ]
Danger | [Hazard statements ]
H314 | [Precautionary statements ]
P280-P305+P351+P338-P310 | [Hazard Codes ]
C | [Risk Statements ]
R14:Reacts violently with water.
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S8:Keep container dry .
S25:Avoid contact with eyes .
S27:Take off immediately all contaminated clothing . | [RIDADR ]
UN 3265 8/PG 2
| [WGK Germany ]
3
| [F ]
10 | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29209090 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colourless liquid | [Uses]
2-Chloro-1,3,2-dioxaphospholane-2-oxide is used in the synthesis of α-naphthylphosphorylcholine as a method to detect phospholipase C activity. | [General Description]
2-Chloro-1,3,2-dioxaphospholane 2-oxide (COP) is a cyclic chlorophosphate reagent that can be prepared from 2-chloro-1,3,2-dioxaphospholane by reacting with molecular oxygen. | [Purification Methods]
It should be distilled under high vacuum as some polymerisation occurs at -1atmospheric pressure. It has IR bands at 3012, 2933, 1477, 1366, 1325, 1040, 924 and 858 cm . It is hydrolysed to HOCH2CH2OPO3H2 in 30minutes in H2O at 100o [IR: Cox & Westheimer J Am Chem Soc 80 5441 1958]. [Beilstein 1 IV 2419.] |
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