| Identification | More | [Name]
6-Chloro-5-(2,3-dichlorophenoxy)-2-methylthio-benzimidazole | [CAS]
68786-66-3 | [Synonyms]
5-CHLORO-6-(2,3-DICHLOROPHENOXY)-2-METHYLTHIO-1H-BENZIMIDAZOLE
6-CHLORO-5-(2,3-DICHLOROPHENOXY)-2-METHYLTHIO-BENZIMIDAZOLE
CGA-89317
FASINEX
TRICLABENDAZOLE
5-chloro-6-(2,3-dichlorophenoxy)-2-(methylthio)-1h-benzimidazol
Tricalbendazole
5-Chloro-6-(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole, CGA-89317, Fasinex
1H-Benzimidazole, 5-chloro-6-(2,3-dichlorophenoxy)-2-(methylthio)-
5-CHLORO-6-(2,3-DICHLOROPHENOXY)-2-(METHYLTHIO)-1H-BENZIMIDAZOL(TRICLABENDAZOLE) | [EINECS(EC#)]
614-728-7 | [Molecular Formula]
C14H9Cl3N2OS | [MDL Number]
MFCD00864519 | [Molecular Weight]
359.66 | [MOL File]
68786-66-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-White Solid | [Melting point ]
175-176°C | [Boiling point ]
240.6°C (rough estimate) | [density ]
1.3875 (rough estimate) | [refractive index ]
1.6000 (estimate) | [storage temp. ]
0-6°C | [solubility ]
Acetonitrile (Slightly, Sonicated), Methanol (Slightly) | [form ]
neat | [pka]
7.91±0.10(Predicted) | [color ]
White to Beige | [Stability:]
Stability | [Usage]
An anthelmintic (fasciola) | [Merck ]
14,9652 | [BCS Class]
4/3 | [InChI]
InChI=1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19) | [InChIKey]
NQPDXQQQCQDHHW-UHFFFAOYSA-N | [SMILES]
C1(SC)NC2=CC(Cl)=C(OC3=CC=CC(Cl)=C3Cl)C=C2N=1 | [CAS DataBase Reference]
68786-66-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3 | [RTECS ]
DD6747000 | [HS Code ]
29339900 | [Toxicity]
LD50 oral in rabbit: 206mg/kg |
| Hazard Information | Back Directory | [Description]
Triclabendazole is a benzimidazole anthelmintic.1 It eliminates both immature and adult flukes in a sheep model of F. hepatica infection when administered at a dose of 10 mg/kg.2 Triclabendazole (5 μM) also protects against glucose- or α-synuclein-induced apoptosis in S. cerevisiae via inhibition of adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A (PKA) nutrient sensing pathway.3 | [Chemical Properties]
Off-White Solid | [Uses]
An anthelmintic (fasciola) | [Uses]
An anthelmintic (fasciola). | [Uses]
Triclabendazole is classified under the category of ‘Anthelmintic flukicide for veterinary use. | [Definition]
ChEBI: 6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole is an aromatic ether. | [Synthesis]
Synthesis of Triclabendazole
 | [in vivo]
Triclabendazole (20-100 mg/kg, Intraperitoneal injection, twice a week for 2 weeks) has anti-tumor effect in the xenograft MDA-MB-231 cells model nude mice[1]. | [IC 50]
Caspase-8; Caspase-9; Caspase 3; Leishmania; Bcl-2; Bax; PARP | [storage]
Store at -20°C | [References]
[1] Patent: CN106632067, 2017, A. Location in patent: Paragraph 0016; 0020 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
|