| Identification | Back Directory | [Name]
Monocrotophos | [CAS]
6923-22-4 | [Synonyms]
Sufos
BALWAN
APARIN
HUKRON
CROTON
CROTOS
Susvin
Ulvair
C 1414
MACABRE
AZODRIN
EFACRON
SD 9129
Apadrin
Azadrin
monocos
OMS 834
Monicil
Azobane
Monocil
MUVACRON
Monodhan
Monostar
Monodrin
Hazodrin
Bilobran
Crisodin
Biloborn
Parryfos
MONOCRON
corophos
Nuvacron
Plantdrin
Crisodrin
CIBA 1414
Croton 36
Kadett 36
Azodrin 60
Azodrin[R]
Azodrin-71
Monocil 40
ENT 27,129
Pillardrin
SD 9129 de
LUPHOS(TM)
NUVACRON(R)
Nuvacron-20
Azodrin 202R
Monokrotofos
Nuvacron 36SL
Glore phos 36
Monokrotofosz
MONOCROTOPHOS
Shell sd 9129
Azodrin(Shell)
Monocrothophos.
E-Monocrotophos
SD-9129 granules
Nuvacron(CibaGeigy)
Monocrotophos (ISO)
Azodrin insecticide
monocrotophos solution
MONOCROTOPHOS TECHNICAL
Monocrotophos Standard
MONOCROTOPHOS, 1GM, NEAT
Des-N-Methyl dicrotophos
MONOCROTOPHOS PESTANAL
MONOCROTOPHOS, 250MG, NEAT
Monocrotophos Solution, 100ppm
Monocrotophos 250mg [6923-22-4]
monocrotophos (bsi,iso,esa,jmaf)
Phosphamidon powder(content3%-25%)
Dimethoxyphosphinyloxy-N-methyl-cis-crotonamide
cis-1-Methyl-2-methyl carbamoyl vinyl phosphate
3-(Dimethoxyphosphinyloxy)N-methyl-cis-crotonamide
CIS-3-[DIMETHOXYPHOSPHINYLOXY]-N-METHYL-CROTONAMIDE
3-Hydroxy-N-methyl-cis-crotonamide dimethyl phosphate
PHOSPHORICACID,DIMETHYLESTER,ESTERWITH3-HYDROXY-N-ME.
Dimethyl phosphate of 3-hydroxy-N-methyl-cis-crotonamide
O,O-Dimetil-O-(2-N-metilcarbamoil-1-metil-vinil)-fosfato
dimethyl (e)-1-methyl-2-(methylcarbamoyl)vinyl phosphate
DIMETHYL CIS-1-METHYL-2-(METHYLCARBAMOYL) VINYL PHOSPHATE
Dimethyl 1-methyl-2-(methylcarbamoyl)vinyl phosphate, cis
Crotonamide, 3-hydroxy-N-methyl-, dimethylphosphate, (E)-
Crotonamide, 3-hydroxy-N-methyl-, dimethylphosphate, cis-
O,O-Dimethyl-O-(2-N-methylcarbamoyl-1-methyl-vinyl)-fosfaat
(E)-diMethyl (4-(MethylaMino)-4-oxobut-2-en-2-yl) phosphate
O,O-Dimethyl-O-(2-N-methylcarbamoyl-1-methyl)-vinyl-phosphat
O,O-Dimethyl-O-(2-N-methylcarbamoyl-1-methyl-vinyl) phosphate
O,O-Dimethyl-O-(1-methyl-2-N-methyl-carbamoyl)-vinyl-phosphat
Phosphate de dimethyle et de 2-methylcarbamoyl 1-methyl vinyle
DIMETHYL PHOSPHATE ESTER OF 3-HYDROXY-N-METHYL-CIS-CROTONAMIDE
Dimethyl phosphate ester with (E)-3-hydroxy-N-methylcrotonamide
(E)-Dimethyl 1-methyl-3-(methylamino)-3-oxo-1-propenyl phosphate
Dimethyl (1E)-1-methyl-3-(methylamino)-3-oxo-1-propenyl phosphate
Dimethyl (1E)-1-methyl-3-(methylamino)-3-oxoprop-1-en-1-yl phosphate
monocrotophos (ISO) dimethyl-1-methyl-2-(methylcarbamoyl)vinyl phosphate
Phosphoric acid [(E)-1-methyl-3-(methylamino)-3-oxo-1-propenyl] dimethyl
phosphoricacid,dimethyl1-methyl-3-(methylamino)-3-oxo-1-propenylester,(E)-
phosphoric acid (e)-dimethyl 1-methyl-3-(methylamino)-3-oxo-1-propenyl ester
Phosphoric acid, dimethyl ester, ester with cis-3-hydroxy-N-methylcrotonamide
Phosphoric acid, dimethyl ester, ester with (E)-3-hydroxy-N-methylcrotonamide
Phosphoric Acid DiMethyl (1E)-1-Methyl-3-(MethylaMino)-3-oxo-1-propenyl Ester
Phosphoric acid, dimethyl ester, ester with 3-hydroxy-N-methylcrotonamide, (E)-
Phosphoric acid, dimethyl 1-methyl-3-(methylamino)-3-oxo-1-propenyl ester, (E)- | [EINECS(EC#)]
230-042-7 | [Molecular Formula]
C7H14NO5P | [MDL Number]
MFCD00055291 | [MOL File]
6923-22-4.mol | [Molecular Weight]
223.16 |
| Hazard Information | Back Directory | [Uses]
Monocrotophos is an organophosphorous insecticide. Monocrotophos is used mainly against cotton pests but it is also used in the protection of citrus, rice, potatoes, vegetables and other crops. | [Definition]
ChEBI: An alkenyl phosphate that is the 4-(methylamino)-4-oxobut-2-en-2-yl ester of dimethyl phosphate. | [Uses]
Insecticide. | [General Description]
Colorless crystals with a mild ester odor, commercial product is a reddish-brown solid. Used as a fast acting insecticide with both systemic and contact action against a wide range of pests on cotton, sugar cane, tobacco, potatoes, peanuts, tomatoes, and ornamentals. Very toxic. | [Air & Water Reactions]
Water soluble. Rapidly hydrolyzed. | [Reactivity Profile]
Monocrotophos is incompatible with the following: Metals, low molecular weight alcohols & glycols [Note: Corrosive to black iron, drum steel, stainless steel 304 & brass. Should be stored at 70-80°F.] . Incompatible with alkaline compounds. | [Health Hazard]
Monocrotophos is an organophosphorus pesticide. It is a cholinesterase inhibitor and acts on the nervous system. Extremely toxic; probable oral lethal dose to humans 5-50 mg/kg or between 7 drops and 1 teaspoon for a 70 kg (150 lb.) person. Repeated inhalation or skin contact with Monocrotophos may, without symptoms, progressively increase susceptibility to poisoning. | [Fire Hazard]
Wear positive pressure breathing apparatus and full protective clothing. Container may explode in heat of fire. Toxic fumes evolved when heated to decomposition. Incompatible with alkaline compounds. Unstable in aqueous solution above pH 7.0; in low molecular weight alcohols and glycols. Stable in ketones and higher molecular weight alcohols and glycols. Stable when stored in glass or polyethylene containers. Relatively stable in sunlight. Keep away from temperatures above 80F; do not store below 70F. Corrosive to black iron, drum steel, stainless steel 304 and brass, but not to glass, aluminum, or stainless steel 316. | [Hazard]
Flammable, dangerous fire risk. Use
may be restricted. Toxic via ingestion, inhala-
tion, and skin absorption. Questionable carcinogen.
Cholinesterase inhibitor.
| [Potential Exposure]
The liquid form is a severely hazardous
pesticide formulation. A potential danger to those
involved in the manufacture, formulation, and application
of this insecticide. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Speed in removing material from skin
is of extreme importance. Shampoo hair promptly if
contaminated. Seek medical attention immediately. If this
chemical has been inhaled, remove from exposure, begin
rescue breathing (using universal precautions, including
resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medical
attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit.
Obtain authorization and/or further instructions from the
local hospital for administration of an antidote or
performance of other invasive procedures. | [Shipping]
UN2783 Organophosphorus pesticides, solid,
toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. | [Incompatibilities]
Alkaline pesticides. Attacks black iron,
drum steel; stainless steel; brass. | [Description]
Monocrotophos is a colorless to reddish-brownsolid with a mild ester odor. Molecular weight = 223.19;Specific gravity (H2O:1)= 13; Boiling point= 125℃; Freezing/Melting point = 53.9℃ (pure); 25- -30℃ (thereddish brown technical product); Vapor pressure =7X10-mm at 20^C; Flash point= >93*C. HazardIdentification (based on NFPA-704 M Rating System):Health 3, Flammability 1, Reactivity 0. Soluble in water.Commercially available as a water-miscible solution. | [Chemical Properties]
Monocrotophos is a colorless to reddishbrown
solid with a mild ester odor. | [Waste Disposal]
Small amounts may be
hydrolyzed with water. Incineration in a unit with
effluent gas scrubbing is recommended for larger amounts.
In accordance with 40CFR165, follow recommendations
for the disposal of pesticides and pesticide containers.
Must be disposed properly by following package label
directions or by contacting your local or federal environmental
control agency, or by contacting your regional
EPA office. | [Environmental Fate]
Plant. Decomposes in plants forming the N-hydroxy compound in small amounts
(Hartley and Kidd, 1987).
Chemical/Physical. Hua et al. (1995) studied the titanium dioxide-mediated photooxidation
of monocrotophos using a recirculating photoreactor. The initial concentration and
flow rate used were 50 nM and 30 mL/minute, respectively. The irradiation
Emits toxic fumes of phosphorus and nitrogen oxides when heated to decomposition
(Sax and Lewis, 1987; Lewis, 1990). | [Metabolic pathway]
Technical monocrotophos contains 75-80% of the Ε-isomer and 9% of the
2-isomer, the balance being various impurities. Most studies on the metabolic
fate of this compound have used purified material containing >99%
E-isomer. Monocrotophos is a systemic vinyl phosphate insecticide with
a particularly high water solubility and low log Kow. This hydrophilic
property influences its metabolism and environmental fate in that it
tends to remain in the water phase and does not bioaccumulate.
The main routes of metabolic degradation are demethylation to des-
O-methylmonocrotophos and hydrolysis to dimethylphosphate and
N-methylacetoacetamide. Hydroxylation of the N-methyl group in animals
and plants followed by N-demethylation are also important from
a toxicological points of view, since these metabolic steps yield active
acetylcholinesterase inhibitors. | [storage]
Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area. Sources of ignition, such as smoking andopen flames, are prohibited where this chemical is handled,used, or stored. Metal containers involving the transfer of 5gallons or more of this chemical should be grounded andbonded. Drums must be equipped with self-closing valves,pressure vacuum bungs, and flame arresters. Use only nonsparking tools and equipment, especially when opening andclosing containers of this chemical. Wherever this chemicalis used, handled, manufactured, or stored, use explosionproof electrical equipment and fittings | [Degradation]
Monocrotophos is thermally labile, decomposing exothermically at
>55°C (PM). This thermo-instability has been known to cause manufacturing
problems. It is relatively stable at acidic and neutral pH values
but it is hydrolysed in alkaline solutions (PM). The DT50s at pH 3, 6 and
9 were 131, 134 and 26 days, respectively. Products of hydrolysis were
N-methylacetoacetamide (2), the main product at alkaline pH values, and
O-desmethylmonocrotophos (3), which predominated in acid and neutral
solutions (Lee et al., 1990). Further decomposition of N-methylacetoacetamide
(2) then gave acetone (4), CO2 and methylamine (5), whereas
under acidic conditions the O-desmethylmonocrotophos was shown to
decompose to inorganic phosphate (6), monomethyl phosphate (7), methanol
(B), acetone (4) and N-methylacetoacetamide (2) (Beynon et al., 1973).
Since monocrotophos does not significantly absorb light at wavelengths
greater than 300 nm, little photolysis would be expected to take place in
sunlight. Photolysis experiments in which aqueous solutions of monocrotophos
were exposed to sunlight in quartz tubes showed no products
other than the hydrolysis products 2 and 3, neither was their rate of
production accelerated. A soil surface photolysis experiment indicated
loss of monocrotophos, probably as CO2, due to microbial action. No
particular photolytic degradation products were detected apart from
minor amounts of the hydrolytic products 2 and 3 (Lee et al., 1990) (see Scheme 1). |
| Safety Data | Back Directory | [Hazard Codes ]
T+;N,N,T+,Xn,F | [Risk Statements ]
24-26/28-50/53-68-67-65-38-11-36-20/21/22 | [Safety Statements ]
1/2-36/37-45-60-61-62-26-16 | [RIDADR ]
UN 2783 | [WGK Germany ]
3 | [RTECS ]
TC4375000 | [HazardClass ]
6.1(a) | [PackingGroup ]
II | [HS Code ]
29241200 | [Safety Profile]
Poison by ingestion,
inhalation, skin contact, intraperitoneal,
subcutaneous, and intravenous routes.
Mutation data reported. Use may be
restricted. When heated to decomposition it
emits very toxic NOx and POx. | [Hazardous Substances Data]
6923-22-4(Hazardous Substances Data) | [Toxicity]
LD50 in male, female rats (mg/kg): 17, 20 orally; 126, 112 dermally (Gaines) |
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