| Identification | More | [Name]
4-Amino-2-picoline | [CAS]
18437-58-6 | [Synonyms]
2-METHYL-4-AMINOPYRIDINE
2-METHYLPYRIDIN-4-AMINE
2-METHYL-PYRIDIN-4-YLAMINE
4-AMINO-2-METHYLPYRIDINE
4-AMINO-2-PICOLINE
4-AMINO-6-PICOLINE
AKOS BBS-00006740
AURORA 2465
4-Pyridinamine,2-methyl-(9CI)
4-AMINO-2-PICOLINE DIHYDROCHLORIDE
4-AMINO-2-METHYLPYRIDINE (4-AMINO-2-PICOLINE)
4-Pyridinamine,2-methyl-
4-Amino-2-methylpyridine ,97%
4-AMINO-2-PICOLINE, 98+%
2-Methyl-4-pyridinamine | [EINECS(EC#)]
625-782-6 | [Molecular Formula]
C6H8N2 | [MDL Number]
MFCD00186509 | [Molecular Weight]
108.14 | [MOL File]
18437-58-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Light yellow Cryst | [Melting point ]
93-97 °C | [Boiling point ]
143°C/9mmHg(lit.) | [density ]
1.068±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Soluble in methanol. | [form ]
Powder | [pka]
9?+-.0.30(Predicted) | [color ]
Tan | [Detection Methods]
HPLC | [InChI]
1S/C6H8N2/c1-5-4-6(7)2-3-8-5/h2-4H,1H3,(H2,7,8) | [InChIKey]
GNCLPNMQEGMNTG-UHFFFAOYSA-N | [SMILES]
Cc1cc(N)ccn1 | [CAS DataBase Reference]
18437-58-6(CAS DataBase Reference) | [Storage Precautions]
Store under nitrogen |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H302-H315-H318-H335 | [Precautionary statements ]
P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | [Hazard Codes ]
Xn,T,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/39:Wear suitable protective clothing and eye/face protection .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Harmful | [HazardClass ]
IRRITANT, TOXIC | [HS Code ]
29333990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow Cryst | [Uses]
4-Amino-2-methylpyridine is used to prepare 2-methyl-pyridin-4-ol; nitrate at 20°C. | [Synthesis]
General procedure for the synthesis of 2-methyl-4-aminopyridine from 2-methyl-4-nitropyridine-N-oxide: 2-methyl-4-nitropyridine-N-oxide (5 g, 32.4 mmol) and iron powder (18.1 g, 324 mmol) were mechanically stirred for 3 hours in acetic acid (300 mL) at 70 °C. After completion of the reaction, the mixture was cooled to room temperature and concentrated under vacuum. The pH of the residue was adjusted to greater than 10 with aqueous NaOH, taking care to use a minimum amount of water. The reaction mixture was transferred to a liquid-liquid extractor and continuously extracted with chloroform for 12 hours. The organic layer was separated and dried over anhydrous sodium sulfate and subsequently concentrated in vacuum to afford the target product 4-amino-2-methylpyridine (3.5 g, >99% yield). | [References]
[1] Patent: WO2004/14913, 2004, A2. Location in patent: Page 81
[2] Patent: EP1403252, 2004, A1. Location in patent: Page 8
[3] Patent: WO2005/30213, 2005, A1. Location in patent: Page/Page column 166
[4] Patent: WO2008/57497, 2008, A2. Location in patent: Page/Page column 292
[5] Patent: WO2007/89669, 2007, A2. Location in patent: Page/Page column 203 |
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