| Identification | More | [Name]
Tetramethylsilane | [CAS]
75-76-3 | [Synonyms]
SILICON TETRAMETHYL
TETRAMETHYLSILANE
TMS
(CH3)4Si
CT2050
Si(CH3)4
tetramethyl-silan
Tetramethylsilicane
TetramethylsilaneNMRgrade
TETRAMETHYLSILANE, 99.99+%, ELECTRONIC G RADE
TETRAMETHYLSILANE (TMS), REFERENCE SUBST ANCE FOR NMR SPECTROSCOPY, PACK. WITH 6
TETRAMETHYLSILANE, 99.9+%, NMR GRADE, A. C.S. REAGENT
TETRAMETHYLSILANE 99.9+% NMR GRADE &
TETRAMETHYLSILANE GAUGING SUBSTANCE FO&
TETRAMETHYLSILANE, ACS, CALIBRATION STD FOR NMR-SPECTROSCOPY
Tetramethylsilane, 99.9%
Tetramethylsilane, NMR grade, 99.9+%
Silane, tetramethyl-
TETRAMETHYLSILANE,REAGENT
Tetramethylsilane [for NMR] | [EINECS(EC#)]
200-899-1 | [Molecular Formula]
C4H12Si | [MDL Number]
MFCD00008274 | [Molecular Weight]
88.22 | [MOL File]
75-76-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless clear liquid | [Melting point ]
-99 °C (lit.) | [Boiling point ]
26-28 °C (lit.) | [density ]
0.648 g/mL at 25 °C(lit.)
| [vapor pressure ]
11.66 psi ( 20 °C)
| [refractive index ]
n20/D 1.358(lit.)
| [RTECS ]
VV5706000 | [Fp ]
−17 °F
| [storage temp. ]
0-6°C
| [solubility ]
0.02g/l | [form ]
liquid | [color ]
colorless | [Specific Gravity]
0.648 | [Stability:]
Stable. Highly flammable-readily forms explosive mixtures with air. Note the boiling point close to room temperature, the low flash point and high vapour pressure. Incompatible with oxidizing agents. Refrigerate before opening. | [explosive limit]
1.0-37.9%(V) | [Water Solubility ]
0.02 G/L (25 ºC) | [Specific Heat Capacity]
Cp(liquid):204.1J/(g·K);Cp(gas):1.63115J/(g·K),at 25℃ | [Hydrolytic Sensitivity]
1: no significant reaction with aqueous systems | [Merck ]
9229 | [BRN ]
1696908 | [Henry's Law Constant]
2.3×10-6 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) | [Dielectric constant]
1.9199999999999999 | [InChI]
1S/C4H12Si/c1-5(2,3)4/h1-4H3 | [InChIKey]
CZDYPVPMEAXLPK-UHFFFAOYSA-N | [SMILES]
C[Si](C)(C)C | [CAS DataBase Reference]
75-76-3(CAS DataBase Reference) | [NIST Chemistry Reference]
Silane, tetramethyl-(75-76-3) | [EPA Substance Registry System]
75-76-3(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS02 | [Signal word ]
Danger | [Hazard statements ]
H224 | [Precautionary statements ]
P210-P403+P233 | [Hazard Codes ]
Xn,F+ | [Risk Statements ]
R12:Extremely Flammable.
R48/20/22:Harmful: danger of serious damage to health by prolonged exposure through inhalation and if swallowed .
R40:Limited evidence of a carcinogenic effect.
R38:Irritating to the skin.
R22:Harmful if swallowed. | [Safety Statements ]
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S33:Take precautionary measures against static discharges .
S3/7:Keep container tightly closed in a cool place .
S16:Keep away from sources of ignition-No smoking .
S9:Keep container in a well-ventilated place . | [RIDADR ]
UN 2810 6.1/PG 3
| [WGK Germany ]
3
| [F ]
10 | [Autoignition Temperature]
842 °F | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
3 | [PackingGroup ]
I | [HS Code ]
29319090 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Flam. Liq. 1 | [Hazardous Substances Data]
75-76-3(Hazardous Substances Data) |
| Hazard Information | Back Directory | [General Description]
A colorless, mildly acidic volatile liquid. Flash point 0°F. Boiling point 78°F. A serious fire hazard. Mildly toxic by ingestion. Emits acrid smoke and fumes when heated to high temperatures. Less dense than water and insoluble in water, but soluble in most organic solvents. Used as an aviation fuel and as an internal standard for nmr analytical instruments. | [Reactivity Profile]
Hydrides, such as TETRAMETHYLSILANE, are reducing agents and react rapidly and dangerously with oxygen and with other oxidizing agents, even weak ones. Thus, they are likely to ignite on contact with alcohols. Hydrides are incompatible with acids, alcohols, amines, and aldehydes. | [Air & Water Reactions]
Highly flammable. TETRAMETHYLSILANE(75-76-3) is insoluble in water. | [Health Hazard]
May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. | [Fire Hazard]
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. | [Chemical Properties]
Tetramethylsilane (TMS) is the simplest tetraalkylsilane. It is a colorless, highly volatile liquid with a characteristic organometallic odor. TMS is chemically stable, insoluble in water, and soluble in most organic solvents.
In nuclear magnetic resonance (NMR) spectroscopy, TMS is widely used as an internal standard for chemical shift measurements. Chemical shift is a relative value and is generally referenced to TMS, whose chemical shift is defined as 0 ppm. The protons in TMS experience a strong shielding effect, requiring a relatively high external magnetic field to achieve resonance. As a result, few compounds exhibit signals at a higher field than TMS, making it an ideal reference standard for NMR analysis. | [Uses]
NMR reference standard. In semiconductor applications (chemical vapor deposition). Tetramethylsilane (TMS) is used as a chemical shift reference for proton, carbon-13, and silicon-29 analysis in organic solvents and is given 0 as its chemical shift position.
| [Uses]
Tetramethylsilane is used as a building block in organometallic chemistry. It acts as a by-product in the production of methyl chlorosilanes. Also, it serves as a precursor to silicon dioxide or silicon carbide. It is used as internal reference standard for the calibration of chemical sift for 1, 13 and 29 NMR spectroscopy. In addition, it is used as an aviation fuel. | [Definition]
ChEBI: Tetramethylsilane is an organosilicon compound that is silane in which the hydrogens have been replaced by methyl groups. | [Preparation]
At present, the synthesis method of Tetramethylsilane mainly comprises two methods, namely, tetrachlorosilane or tetraethoxysilane is reacted with methyl magnesium iodide to prepare the tetramethylsilane. The second one is prepared by reacting chloromethane and silicon powder in the presence of copper catalyst and then carrying out fine fractionation. | [Hazard]
Flammable, high fire risk. | [Purification Methods]
Distil it from conc H2SO4 (after shaking with it) or LiAlH4, through a 5ft vacuum-jacketed column packed with glass helices into an ice-cooled condenser, then percolate it through silica gel to remove traces of halide. [Beilstein 4 IV 3875.] | [Toxics Screening Level]
Tetramethysilane had an ITSL of 1300 μg/m3 annual average. |
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Alfa Aesar
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Energy Chemical
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Maya High Purity Chemicals
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