| Identification | More | [Name]
2-Amino-5-bromopyrimidine | [CAS]
7752-82-1 | [Synonyms]
2-AMINO-5-BROMOPYRIMIDINE
5-BROMO-2-AMINOPYRIMIDINE
5-BROMO-2-PYRIMIDINAMINE
5-BROMO-2-PYRIMIDINYLAMINE
5-BROMOPYRIMIDIN-2-YLAMINE
TIMTEC-BB SBB000184
5-BROMOPYRIMIDIN-2-AMINE
2-Amino-5-Bormopyrimidine
2-Pyrimidinamine, 5-bromo-
2-Amino-5-bromopyrimide
2-Amino-5-bromopyrimidine ,98%
5-Bromopyrimidine-2-amine | [EINECS(EC#)]
629-581-4 | [Molecular Formula]
C4H4BrN3 | [MDL Number]
MFCD00012341 | [Molecular Weight]
174 | [MOL File]
7752-82-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Yellow Solid | [Melting point ]
241-243 °C (lit.) | [Boiling point ]
340.7±34.0 °C(Predicted) | [density ]
1.844±0.06 g/cm3(Predicted) | [storage temp. ]
Refrigerator (+4°C) | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Crystalline Powder, Crystals or Flakes | [pka]
1.93±0.10(Predicted) | [color ]
White to light beige | [Water Solubility ]
Insoluble | [Detection Methods]
HPLC,NMR | [InChI]
InChI=1S/C4H4BrN3/c5-3-1-7-4(6)8-2-3/h1-2H,(H2,6,7,8) | [InChIKey]
UHRHPPKWXSNZLR-UHFFFAOYSA-N | [SMILES]
C1(N)=NC=C(Br)C=N1 | [CAS DataBase Reference]
7752-82-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS07,GHS09 | [Signal word ]
Warning | [Hazard statements ]
H302-H319-H400 | [Precautionary statements ]
P264-P270-P273-P280-P301+P312-P305+P351+P338 | [Hazard Codes ]
Xn,N,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36:Irritating to the eyes.
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 3077 9/PG 3
| [WGK Germany ]
3
| [Hazard Note ]
Harmful | [HazardClass ]
IRRITANT, IRRITANT-HARMFUL | [PackingGroup ]
III | [HS Code ]
29335900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Aquatic Acute 1
Eye Irrit. 2 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Solid | [Uses]
2-Amino-5-bromopyrimidine was employed:
- in synthesis of pyridine, pyrimidine and pyridinone C-nucleoside phosphoramidites
- in synthesis of 2-phthalimido-5-bromopyrimidine
- as intermediate for the preparation of sulfanilamides and amino acids containing the pyrimidine ring system. The products are potential antiviral agents
| [General Description]
Crystal structure of 2-amino-5-bromopyrimidine was studied. | [Synthesis]
The synthesis of 2-Amino-5-bromopyrimidine is as follows:The 2-aminopyrimidine (2.5g, 26.29mmol) was dissolved in acetonitrile (25mL) was added N- bromosuccinimide (4.6g, 27.9mmol) under ice-cooling, stirred in the dark overnight at room temperature. Recovery of the solvent under reduced pressure, washed with water (100 mL) was washed, filtered off with suction, and dried in vacuo to give a white solid. Yield: 97%.
 | [storage]
Store in cool, well ventilated area. Keep container tightly closed. Light sensitive. Store under argon. | [References]
[1] Journal of Organic Chemistry, 2012, vol. 77, # 16, p. 6908 - 6916
[2] European Journal of Organic Chemistry, 2018, vol. 2018, # 43, p. 5921 - 5934
[3] Patent: CN106588884, 2017, A. Location in patent: Paragraph 0210; 0214; 0215; 0216
[4] Synthesis, 2004, # 17, p. 2809 - 2812
[5] Chemical Communications, 2017, vol. 53, # 44, p. 5997 - 6000 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
|