| Identification | More | [Name]
Triethyl orthoacetate | [CAS]
78-39-7 | [Synonyms]
1,1,1-TRIETHOXYETHANE
ETHYL ORTHOACETATE
LABOTEST-BB LT00067780
ORTHOACETIC ACID TRIETHYL ESTER
TEOA
TRIETHYL-O-ACETATE
TRIETHYL ORTHACETATE
TRIETHYL ORTHOACETATE
TRIETHYL-ORTHO ACETOACETATE
1,1,1-triethoxy-ethan
Triethylorthoacetate,98%
Triethyl Orthoacetate-1,2-13C2
Ethane, 1,1,1-triethoxy-
Triethylorthoacetat
triethyl ester orthoacetic acid
ETHYL O-ACETATE
Methylorthoformic acid triethyl ester
Orthoacetic acid triethyl | [EINECS(EC#)]
201-112-4 | [Molecular Formula]
C8H18O3 | [MDL Number]
MFCD00009223 | [Molecular Weight]
162.23 | [MOL File]
78-39-7.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colourless to slightly yellowish liquid | [Boiling point ]
142 °C (lit.) | [density ]
0.885 g/mL at 25 °C(lit.)
| [vapor pressure ]
3.4 hPa (20 °C) | [refractive index ]
n20/D 1.396(lit.)
| [RTECS ]
KJ4075000 | [Fp ]
97 °F
| [storage temp. ]
Flammables area | [solubility ]
soluble in Chloroform, Ethyl Acetate | [form ]
Liquid | [color ]
Clear colorless to slightly yellow | [explosive limit]
0.9-7.0%(V) | [Water Solubility ]
SLIGHTLY SOLUBLE | [Sensitive ]
Moisture Sensitive | [BRN ]
506201 | [InChI]
1S/C8H18O3/c1-5-9-8(4,10-6-2)11-7-3/h5-7H2,1-4H3 | [InChIKey]
NDQXKKFRNOPRDW-UHFFFAOYSA-N | [SMILES]
CCOC(C)(OCC)OCC | [LogP]
2.6 at 20℃ | [Uses]
Intermediate. | [CAS DataBase Reference]
78-39-7(CAS DataBase Reference) | [NIST Chemistry Reference]
Ethane, 1,1,1-triethoxy-(78-39-7) | [EPA Substance Registry System]
78-39-7(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS02 | [Signal word ]
Warning | [Hazard statements ]
H226 | [Precautionary statements ]
P210 | [Hazard Codes ]
Xi | [Risk Statements ]
R10:Flammable.
R36/38:Irritating to eyes and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 3272 3/PG 3
| [WGK Germany ]
1
| [Autoignition Temperature]
455 °C | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29159080 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Flam. Liq. 3 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Sodium chloride-->Ammonium chloride-->4-Chlorobenzaldehyde-->Acetamide-->Sodium ethylate solution,in ethyl alcohol-->Trimethyl orthoacetate-->Thymol Blue | [Preparation Products]
Permethrin-->1,2-Phenylenediacetic acid-->ethyl 3,3-dimethylpent-4-en-1-oate-->BROTIZOLAM-->4-Amino-6-methylpyrimidine-5-carbonitrile ,97%-->ethyl 4,6,6-trichloro-3,3-dimethyl-hex-5-enoate-->Diethyl acetamidomalonate-->Tazarotene-->4,4,4-TRICHLOROACETOACETIC ACID ETHYL ESTER-->2-ethylquinazolin-4-ol-->6-BROMO-2-METHYLOXAZOLO[4,5-B]PYRIDINE-->2-[3-(DIMETHYLAMINO)-1-METHOXY-2-PROPENYLIDENE]MALONONITRILE-->1,3,5(10), 9(11)-ESTRATETRAEN-3-OL-17-ONE-->ETHYL TRANS-4-DECENOATE-->4-Octenoic acid, 6-methyl-, ethyl ester, (E)- (9CI) |
| Questions And Answer | Back Directory | [Description]
Triethyl orthoacetate is the ethyl orthoester of acetic acid. It is an oily liquid with a pungent odor. Triethyl orthoacetate is used as a water scavenger and as intermediate for synthesis of pharmaceuticals. It is used in organic synthesis for the introduction of the acetate group to an alcohol and in the Johnson-Claisen rearrangement.
| [Reference]
- J. S. Lindsey, I. C. Schreiman, H. C. Hsu, P. C. Kearney, A. M. Marguerettaz, Rothemund and Adler-Longo reactions revisited: synthesis of tetraphenylporphyrins under equilibrium conditions, The Journal of Organic Chemistry, 1987, vol. 52, pp. 827-836
- R. C. Capozza, Polymeric orthoesters housing beneficial drug for controlled release therefrom, Patent US4066747A
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Weifang Mingran Chemical Co., Ltd. Gold
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Alfa Aesar
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Jia Xing Isenchem Co.,Ltd
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