| Identification | More | [Name]
Ethyl trifluoroacetate | [CAS]
383-63-1 | [Synonyms]
ETHYL 2,2,2-TRIFLUOROACETATE
ETHYL TRIFLUOROACETATE
RARECHEM AL BI 0416
TIMTEC-BB SBB008466
TRIFLUOROACETIC ACID ETHYL ESTER
VITAS-BB TBB000648
aceticacid,trifluoro-,ethylester
CF3COOC2H5
Ethyl ester of Trifluoroacetic acid
Ethyl trifluoroethanoate
ethylperfluoroacetate
Trifluoressigsαureethylester
trifluoro-aceticaciethylester
3,4,5-Trimethoxybenzenesulfonic Acid Sodium
TFAET
ETHYL TRIFLUOROACETATE 98% (GC)
Ethyl trifluoroacetate,99%
Ethyl trifluoroacetate 99%
2,2,2-TRIFLOUROETHYL ACETATE (TFAET)
Ethyltrifluoracetat | [EINECS(EC#)]
206-851-6 | [Molecular Formula]
C4H5F3O2 | [MDL Number]
MFCD00000419 | [Molecular Weight]
142.08 | [MOL File]
383-63-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless to yellow liquid | [Melting point ]
-78 °C
| [Boiling point ]
60-62 °C(lit.)
| [density ]
1.194 g/mL at 25 °C(lit.)
| [vapor pressure ]
18.5kPa@20°C | [refractive index ]
n20/D 1.307(lit.)
| [Fp ]
30 °F
| [storage temp. ]
2-8°C
| [solubility ]
4g/l | [form ]
Liquid | [pka]
0.43[at 20 °C] | [color ]
Clear | [Specific Gravity]
1.194 | [PH]
4 (4g/l, H2O, 20℃) | [Water Solubility ]
HYDROLYSIS | [Sensitive ]
Moisture Sensitive | [Detection Methods]
GC | [BRN ]
1761411 | [Henry's Law Constant]
8.9×10-4 mol/(m3Pa) at 25℃, Burkholder et al. (2019) | [Stability:]
Hygroscopic, Moisture Sensitive, Volatile | [InChI]
1S/C4H5F3O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3 | [InChIKey]
STSCVKRWJPWALQ-UHFFFAOYSA-N | [SMILES]
CCOC(=O)C(F)(F)F | [LogP]
0.79-1.032 at 25℃ | [CAS DataBase Reference]
383-63-1(CAS DataBase Reference) | [NIST Chemistry Reference]
Acetic acid, trifluoro-, ethyl ester(383-63-1) | [Storage Precautions]
Moisture sensitive | [EPA Substance Registry System]
383-63-1(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
  
GHS02,GHS05,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H225-H302-H315-H318-H335 | [Precautionary statements ]
P210-P261-P280-P305+P351+P338 | [Hazard Codes ]
F,Xn,C | [Risk Statements ]
R11:Highly Flammable.
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R34:Causes burns. | [Safety Statements ]
S9:Keep container in a well-ventilated place .
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/39:Wear suitable protective clothing and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN 1993 3/PG 2
| [WGK Germany ]
1
| [Hazard Note ]
Flammable/Corrosive | [TSCA ]
T | [REACH Registrations]
Active | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29159080 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Flam. Liq. 2
Skin Irrit. 2
STOT SE 3 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Trifluoroacetic acid-->Ethyl trifluoromethanesulfonate | [Preparation Products]
6,7-Dimethoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride-->Hexafluoroacetylacetone-->Methyl5,5,5-trifluoro-4-oxopentanoate-->2-Amino-6-t-butyl-4-(trifluoromethyl)pyrimidine-->2-Amino-4-phenyl-6-(trifluoromethyl)pyrimidine-->2-[1-Methyl-5-(trifluoromethyl)pyrazol-3-yl]-thiophene-5-carboxaldehyde-->Europium D-3-trifluoroacetylcamphorate-->3-Trifluoroacetyl-D-camphor-->Efavirenz-->1,1,1-Trifluoro-2-hexanone-->8-Chloro-2-(trifluoromethyl)quinoline-4-carbonitrile-->4-(Trifluoromethyl)-alpha,alpha,alpha-trifluoroacetophenone-->4,4,4-Trifluoro-1-phenyl-1,3-butanedione-->Benzaldehyde diethyl acetal-->1,1,1-Trifluoro-5,5-dimethyl-2,4-hexanedione-->2-(Trifluoromethyl)pyrimidine-4,6-diol-->3'-Methoxy-2,2,2-trifluoroacetophenone-->3-Phenyl-1,1,1-trifluoropropan-2-one-->1-(2-Amino-5-chlorophenyl)-2,2,2-trifluoroethanone |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to yellow liquid | [Uses]
Ethyl Trifluoroacetate is an intermediate used in the synthesis of various pharmaceutically active molecules and agricultural products. Ethyl Trifluoroacetate is also useful for the preparation of tri
fluoroacylated compounds. | [Uses]
Widely used in the synthetic process of medicine, pesticides and organic intermediate. | [Definition]
ChEBI: TRIFLUOROACETIC ACID ETHYL ESTER is an organohalogen compound. It is functionally related to a carboxylic acid. | [Preparation]
Trifluoroacetic acid and ethanol were used as starting materials with strong-acid cation exchange resin as catalysts at 40 ~ 50 she℃. Add ethanol drop and temperature rising reflux divides the mixture of water and ethanol. After that, collect the mix of thick product ethanol and Ethyl trifluoroacetate. The crude product collected is added a small amount of water, and layering can obtain a content of more than 99.5%. The qualified product Ethyl trifluoroacetate, whose moisture is less than 0.1%, yields more than 95%.
| [Synthesis Reference(s)]
Journal of the American Chemical Society, 72, p. 3527, 1950 DOI: 10.1021/ja01164a056 | [Flammability and Explosibility]
Highlyflammable(100%) | [Purification Methods]
Fractionate it through a long Vigreux column (p 11). IR has max at 1800 (CO2) and 1000 (OCO) cm-1 [Fuson et al. J Chem Phys 20 1627 1952, Bergman J Org Chem 23 476 1958]. [Beilstein 2 IV 463.] |
|
| Company Name: |
Alfa Aesar
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400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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| Telephone: |
0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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