| Identification | More | [Name]
2-Fluoro-6-methoxyphenylboronic acid | [CAS]
78495-63-3 | [Synonyms]
(2-FLUORO-6-METHOXYBENZENE)BORONIC ACID
2-FLUORO-6-METHOXYPHENYLBORONIC ACID
AKOS BRN-0424
2-FLUORO-6-METHOXYLPHENYLBORONIC ACID
2-Fluoro-6-Methoxyphenylboroni
2-Fluoro-6-methoxybenzeneboronic acid 96%
2-Fluoro-6-methoxybenzeneboronicacid96%
3-Fluoroanisole-2-boronic acid | [Molecular Formula]
C7H8BFO3 | [MDL Number]
MFCD02179483 | [Molecular Weight]
169.95 | [MOL File]
78495-63-3.mol |
| Questions And Answer | Back Directory | [Preparation]
Under effective stirring, a suspension of reduced iron powder (50 mmol) in 80 mL of ethanol was added to concentrated hydrochloric acid (5 mmol), heated at 65 °C for 0.5 h, and then cooled to 55–60 °C over 10 min. Then, 8 mL of 25% ammonium chloride aqueous solution was added. Substituted 4-bromo-nitronaphthalene (10 mmol) was added in portions (exothermic) while maintaining the internal temperature at 65–80 °C. The mixture was stirred at 55–65 °C for another 1–3 h and cooled to 40 °C. Diatomaceous earth was added, and the mixture was filtered through a diatomaceous earth mat. The filter cake was washed with dichloromethane (20 mL), and the liquid phase was extracted with dichloromethane. The organic phase was dried over sodium sulfate and concentrated under reduced pressure to obtain the desired 4-bromo-1-naphthylamine. |
| Chemical Properties | Back Directory | [Melting point ]
120-125 °C (lit.) | [Boiling point ]
303.1±52.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
8.35±0.58(Predicted) | [color ]
White to Off-White | [InChI]
InChI=1S/C7H8BFO3/c1-12-6-4-2-3-5(9)7(6)8(10)11/h2-4,10-11H,1H3 | [InChIKey]
XOVMDVZAWWQSDC-UHFFFAOYSA-N | [SMILES]
B(C1=C(OC)C=CC=C1F)(O)O | [CAS DataBase Reference]
78495-63-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P280a-P304+P340-P305+P351+P338-P405-P501a | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
2931900090 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Uses]
Reactant for:• ;Preparation of functionally selective allosteric modulators of GABAA receptors1• ;Suzuki cross-coupling reaction2,3• ;Preparation of inhibitors of the checkpoint kinase Wee14 | [Uses]
suzuki reaction |
|
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
|