| Identification | More | [Name]
4-Methoxycinnamic acid | [CAS]
830-09-1 | [Synonyms]
(2E)-3-(4-METHOXYPHENYL)ACRYLIC ACID
3-(4-methoxyphenyl)-2-propenoic acid
3-(4-METHOXY-PHENYL)-ACRYLIC ACID
4-METHOXYCINNAMIC ACID
AKOS B000181
AKOS BB/0034
AKOS BBS-00000769
(E)-3-(4-METHOXYPHENYL)ACRYLIC ACID
LABOTEST-BB LT00108121
METHOXYCINNAMIC ACID,4-
O-METHYL-P-COUMARIC ACID
O-METHYL-P-CUMARIC ACID
OTAVA-BB BB0123400502
PMCA
P-METHOXYCINNAMIC ACID
RARECHEM BK HC T257
TIMTEC-BB SBB005717
TRANS-3-(4-METHOXYPHENYL)ACRYLIC ACID
TRANS-4-METHOXYCINNAMIC ACID
(2E)-3-(4-Methoxyphenyl)-2-propenoic acid | [EINECS(EC#)]
213-405-4 | [Molecular Formula]
C10H10O3 | [MDL Number]
MFCD00004398 | [Molecular Weight]
178.18 | [MOL File]
830-09-1.mol |
| Chemical Properties | Back Directory | [Appearance]
white fine crystalline powde | [Melting point ]
173.5 °C(lit.)
| [Boiling point ]
250.41°C (rough estimate) | [density ]
1.1479 (rough estimate) | [refractive index ]
1.5088 (estimate) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Soluble in dimethyl sulfoxide and methanol. | [form ]
Fine Crystalline Powder | [pka]
pK1:4.539 (25°C) | [color ]
White | [Detection Methods]
HPLC,NMR | [InChI]
InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12) | [InChIKey]
AFDXODALSZRGIH-UHFFFAOYSA-N | [SMILES]
C(O)(=O)C=CC1=CC=C(OC)C=C1 | [LogP]
2.680 | [CAS DataBase Reference]
830-09-1(CAS DataBase Reference) | [NIST Chemistry Reference]
2-Propenoic acid, 3-(4-methoxyphenyl)-(830-09-1) | [EPA Substance Registry System]
830-09-1(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
UD3391300
| [F ]
8 | [Hazard Note ]
Irritant | [TSCA ]
Yes | [REACH Registrations]
Active | [HS Code ]
29173990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
white fine crystalline powde | [Uses]
4-Methoxycinnamic acid(p-MCA) exerted antihyperglycemic/hypoglycemic effect by stimulating insulin secretion from pancreas and could be developed into a new potential for therapeutic agent used in type 2 diabetic patients.
| [Definition]
ChEBI: A methoxycinnamic acid having a single methoxy substituent at the 4-position on the phenyl ring. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 79, p. 3452, 1957 DOI: 10.1021/ja01570a037
Tetrahedron Letters, 31, p. 5913, 1990 DOI: 10.1016/S0040-4039(00)97992-9 | [Synthesis]
4-methoxycinnamic acid is synthesized by refluxing 4-coumaric acid with potassium carbonate and methyl iodide in acetone[1]. | [Purification Methods]
Crystallise the acid from MeOH to constant melting point and UV spectrum. [Beilstein 10 IV 1005.] | [References]
[1] Hidalgo, W., Kai, M., & Schneider, B. (2015). 4-Methoxycinnamic acid – An unusual phenylpropanoid involved in phenylphenalenone biosynthesis in Anigozanthos preissii. Phytochemistry, 117, 476–481. https://doi.org/10.1016/j.phytochem.2015.07.017
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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