Back to ChemicalBook Home--->CAS DataBase List--->859-18-7

859-18-7

859-18-7 Structure

859-18-7 Structure
IdentificationBack Directory
[Name]

Lincomycin hydrochloride
[CAS]

859-18-7
[Synonyms]

Lizpion
Lincorex
U-10149A
Lincogap
Lincocin
Luniamycin
Pelancocin
Lintamycin
Lyncomycin,HCl
LINCOMYCIN HCL
Lincoymcin Hcl
lincomycin solution
Lincomycin (U-10149A)
LINCOCIN HYDROCHLORIDE
Lincocin hydrocheoride
LINCOMYCIN CHLOROHYDRATE
LINCOMYCIN HYDROCHLORIDE
Lineomycin Hydrochloride
LINOCOMYCIN HYDROCHLORIDE
Lincomycin hydrochloride 90%
lincomycin standard solution
Linocin, NSC 70731, U 10149a
Lincomycin hydrochloride BP98
LINCOMYCINHYDROCHLORIDEANHYDROUS
Lincomycin hydrochloride (Lincocin)
LincoMycin hydrochloride (U-10149A)
LINCOMYCIN HYDROCHLORIDE >= 95.0% (T
Lincomycin hydrochloride monohydrate
LINCOMYCIN HYDROCHLORIDE CELL CULTURE*TE STED
N-[2-HYDROXY-1-(3,4,5-TRIHYDROXY-6-METHYLSULFANYL-OXAN-2-YL)-PROPYL]-1-METHYL-4-PROPYL-PYRROLIDINE-2-CARBOXAMIDE
Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside hydrochloride
ALPHA-METHYL-6,8-DIDEOXY-6-[1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO]-1-THIO-D-ERYTHRO-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE
METHYL 6,8-DIDEOXY-6-(1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO)-1-THIO-D-ERYTHRO-ALPHA-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE
Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside hydrochloride
(2S-trans)-Methyl 6,8-Dideoxy-6-[[(1-Methyl-4-propyl-2-pyrrolidinyl)carbonyl] aMino]-1-thio-D3-threo-α-D-galactooctopyranoside Hydrochloride
methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-α-D-galacto-octopyranoside,hydrochloride (1:1)
(2S,E)-Methyl-6,8-didezoxy-6(1-methyl-4-propylpirrolidine-yl-carbonylamino)-1-thio-D-eritro-a-D-halaktooktopiranoziide, hydrochloride monohydrate
D-erythro-.alpha.-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(2S,4R)-1-methyl-4-propyl-2-pyrrolidinylcarbonylamino-1-thio-, monohydrochloride
D-erythro-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, monohydrochloride, trans-a- (8CI)
Methyl (2S-trans)-6,8-dideoxy-6-[[(1-methyl-4-propylpyrrolidin-2-yl)carbonyl]amino]-1-thio-D-erythro-alpha-D-galacto-octopyranoside monohydrochloride
Lincocin hydrochloride, Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside hydrochloride
D-erythro-a-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, monohydrochloride, (2S-trans)-
D-erythro-a-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, monohydrochloride (9CI)
(2S,4R)-N-{(1S)-2-hydroxy-1-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)-tetrahydro-2H-2-pyranyl]propyl}-1-methyl-4-propylpyrrolidine-2-carboxamide Hydrochloride
Lincomycin hydrochloride,Lincocin hydrochloride, Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside hydrochloride
[EINECS(EC#)]

212-726-7
[Molecular Formula]

C18H35ClN2O6S
[MDL Number]

MFCD00058237
[MOL File]

859-18-7.mol
[Molecular Weight]

443
Chemical PropertiesBack Directory
[Appearance]

Crystalline
[Melting point ]

156-158C
[storage temp. ]

2-8°C
[solubility ]

H2O: 50 mg/mL, clear, colorless
[color ]

white to white with yellow cast
[Water Solubility ]

Soluble in water.
Hazard InformationBack Directory
[Chemical Properties]

Crystalline
[Uses]

Lincomycin hydrochloride is a salt of lincomycin formed at the basic N-methylproline. The hydrochloride salt is the preferred formulation for pharmaceutical use. Lincomycin hydrochloride is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.
[Uses]

An antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.
[Uses]

Antibacterial;Ribosomal protein synthesis inhibitor
Safety DataBack Directory
[Hazard Codes ]

Xi,Xn
[Risk Statements ]

36/37/38-20/21/22
[Safety Statements ]

26-36
[WGK Germany ]

2
[RTECS ]

RH6315000
[F ]

10
[HS Code ]

29419000
Questions And AnswerBack Directory
[Antibiotic medicines]

Lincomycin hydrochloride appears as a white crystalline powder at room temperature with slight odor or special smell and bitter taste. It is soluble in water and methanol. Feed often applied its hydrochloride salt form. The drug is the product during the growth of the population of the Streptomyces genus (Streptomyces lincolnensis), as a kind of lincosamides alkaline antibiotics. Through interaction with the 50S ribosomal subunit of the sensitive bacteria, it prevents the peptide chain elongation, thereby inhibiting protein synthesis of the bacterial cell with antimicrobial effect. However, at high concentrations, it also has bactericidal effect on the highly sensitive bacteria. Its antibacterial spectrum is the same as lincomycin but with a stronger antibacterial activity and can be subject to oral absorption quickly and completely (about 90%) with meal having little effect on the absorption. Lincomycin hydrochloride mainly has strong antibacterial effect against Gram-positive bacteria, and some anaerobic bacteria as well as Mycoplasma with its antibacterial spectrum narrower than erythromycin. Staphylococcus aureus, Streptococcus pneumoniae and Mycoplasma pneumonia Mycoplasma hyopneumoniae, and Mycoplasma gallisepticum are sensitive to the chemicals, but enterococci is generally resistant to the chemicals; anaerobic bacteria such as Bacteroides spp., Clostridium tetani, Clostridium difficile, Clostridium perfringens and Peptococcus are also sensitive to the chemicals. It is mainly used for the treatment of infections caused by Gram-positive bacteria in particular the various penicillin-resistant Gram-positive bacteria , the poultry chronic respiratory disease caused by Mycoplasma, swine enzootic pneumonia, anaerobic infections such as chicken necrotizing enterocolitis. It can also be used for the treatment of treponema dysentery, toxoplasmosis and actinomycosis of dogs and cats.
Lincomycin hydrochloride has therapeutic effect when being used for the treatment of Sepsis, female genital tract, endometritis, non-gonococcal tubo-ovarian abscess, pelvic cellulitis; postoperative vaginal annex infections, peritonitis, abscesses, pneumonia, lung abscess, skin and soft tissue infections caused by most Gram-negative bacteria and some anaerobic bacteria. It can also be used for the surgical adjuvant treatment of Sepsis caused by streptococci and staphylococci, bone and joint infections, chronic bone and joint infections as well as the acute hematogenous osteomyelitis of Staphylococcus aureus. But this product can’t penetrate into cerebrospinal fluid and therefore not suitable for the treatment of meningitis. Topical administration can be applied for the treatment of Gram-positive bacteria purulent infection.
[Clinical application]

1. Oral formulations is suitable for treating respiratory infections, abdominal infection, female reproductive tract infections, pelvic infections, skin and soft tissue infections caused by sensitive Staphylococcus aureus and Streptococcus pneumoniae.
2. In addition to the treatment of the above infections, injected formulations are suitable for treatment of severe infections caused by streptococcus, pneumococcus and staphylococcus such as the surgical adjuvant therapy of septicemia, bone and joint infections, chronic bone and joint infections and Staphylococcus-induced acute hematogenous osteomyelitis.
3. Lincomycin hydrochloride may also be used for the treatment of infectious diseases in patients allergic to penicillin or not suitable for administration of penicillin-type drugs.
Tablets: Each tablet 0.25g, 0.5g; Injection: each 0.2g, 0.6g.
This information is edited by Xiongfeng Dai from Chemicalbook.
Spectrum DetailBack Directory
[Spectrum Detail]

Lincomycin hydrochloride(859-18-7) MS
859-18-7 suppliers list
Company Name: Anhui Royal Chemical Co., Ltd.
Tel: +86-025-86736275
Fax:
Website: www.royal-chem.com
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-13650506873
Fax:
Website: www.chemdad.com
Company Name: HubeiwidelychemicaltechnologyCo.,Ltd
Tel: 18627774460
Fax:
Website: www.chemicalbook.com/ShowSupplierProductsList1110588/0.htm
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Fax: 027-59338440
Website: www.chemicalbook.com/ShowSupplierProductsList1549548/0.htm
Company Name: Xiamen AmoyChem Co., Ltd
Tel: +86 592-605 1114
Fax:
Website: www.amoychem.com
Company Name: Chemwill Asia Co.,Ltd.
Tel: 86-21-51086038
Fax: 86-21-51861608
Website: www.chemwill.com
Company Name: Cangzhou Wanyou New Material Technology Co.,Ltd
Tel: 18631714998
Fax:
Website: www.chemicalbook.com/ShowSupplierProductsList1382651/0.htm
Company Name: Hubei XinRunde Chemical Co., Ltd.
Tel: +8615102730682; +8618874586545
Fax: 02783214688
Website: www.xrdchem.guidechem.com
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Fax:
Website: www.dakentech.com
Company Name: career henan chemical co
Tel: +86-371-86658258
Fax:
Website: www.coreychem.com
Company Name: PI & PI BIOTECH INC.
Tel: 020-81716320
Fax: 020-81716319
Website: www.pipitech.com
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 86-0551-65418684 18949823763
Fax: 86-0551-65418684
Website: www.tnjchem.com
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Fax: 0371-55170693
Website: www.tianfuchem.net
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Fax: +86-0592-6210733
Website: www.mainchem.com
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Fax: 0755-23311925
Website: www.chemicalbook.com/ShowSupplierProductsList30406/0_EN.htm
Company Name: Hubei Tuochukangyuan Pharmaceutical Co.,Ltd.  Gold
Tel:027-86939098,89082698,18995659299,13317199916,15392822292,13607115983,027-89771658
Fax:+86-027-86939098
Website:www.tcky-api.com
Company Name: Hubei Jinsuo Biological Technology Co., Ltd.  Gold
Tel:13627110650;027-8375119;QQ2982627749
Fax:027-83751119
Website:www.jinsuobio.com
Company Name: Wuhan yuqing jiaheng pharmaceutical co. LTD  Gold
Tel:027-83855381 15827508403
Fax:027-83855381
Website:www.chemicalbook.com/ShowSupplierProductsList61923/0.htm
Tags:859-18-7 Related Product Information
7179-49-9 74223-64-6 507-09-5 88-12-0 143390-89-0 67-56-1 62-55-5 21462-39-5 872-50-4 10102-17-7 123-75-1 101200-48-0 99-76-3 119-36-8 96-33-3 119413-54-6