| Identification | Back Directory | [Name]
Radezolid | [CAS]
869884-78-6 | [Synonyms]
RX 1741
RX-1741
radezolid
Unii-53pc6lo35w
RX-1741;RX 1741;RX1741
N-[[(5S)-3-[2-Fluoro-4'-[[(1H-1,2,3-triazol-5-yLmethyl)amino]methyl][1,1'-biphenyl]-4-yl]-2-ox
(5S)-N-[3-(2-fluoro-4'-{[(1H-[1,2,3]triazol-4-ylmethyl)amino]methyl}biphenyl-4-yl)-2-oxo-oxazolidin-5-ylmethyl]acetamide
N-[[(5S)-3-[2-Fluoro-4'-[[(1H-1,2,3-triazol-5-ylmethyl)amino]methyl][1,1'-biphenyl]-4-yl]-2-oxo-5-oxazolidinyl]methyl]acetamide
Acetamide, N-[[(5S)-3-[2-fluoro-4'-[[(1H-1,2,3-triazol-5-ylmethyl)amino]methyl][1,1'-biphenyl]-4-yl]-2-oxo-5-oxazolidinyl]methyl]- | [Molecular Formula]
C22H23FN6O3 | [MDL Number]
MFCD22628873 | [MOL File]
869884-78-6.mol | [Molecular Weight]
438.45 |
| Chemical Properties | Back Directory | [Boiling point ]
712.5±60.0 °C(Predicted) | [density ]
1.336 | [storage temp. ]
Store at -20°C | [solubility ]
≥43.8 mg/mL in DMSO; insoluble in H2O; ≥18.08 mg/mL in EtOH with gentle warming | [form ]
solid | [pka]
15.53±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Radezolid (RX-1741) is a oxazolidinone antibiotic. Radezolid is active against Staphylococcus, Chlamydia, and Legionella species, and remains active against Linezolid-resistant strains[1][2]. | [IC 50]
Oxazolidinone | [storage]
Store at -20°C | [References]
[1] Lemaire S, et al. Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. DOI:10.1128/AAC.01724-09
[2] Locke JB, et al. Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations.
Antimicrob Agents Chemother. 2010 Dec;54(12):5337-43. DOI:10.1128/AAC.00663-10 |
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