| Identification | Back Directory | [Name]
diMethyl lithosperMate B | [CAS]
875313-64-7 | [Synonyms]
dmLSB
diMethyl lithosperMate B
Lithospermic acid B dimethyl ester
3-Benzofurancarboxylic acid, 2-(3,4-dihydroxyphenyl)-4-[(1E)-3-[(1R)-1-[(3,4-dihydroxyphenyl)methyl]-2-methoxy-2-oxoethoxy]-3-oxo-1-propen-1-yl]-2,3-dihydro-7-hydroxy-, (1R)-1-[(3,4-dihydroxyphenyl)methyl]-2-methoxy-2-oxoethyl ester, (2S,3S)- | [Molecular Formula]
C38H34O16 | [MDL Number]
MFCD32005142 | [MOL File]
875313-64-7.mol | [Molecular Weight]
746.67 |
| Chemical Properties | Back Directory | [Boiling point ]
968.3±65.0 °C(Predicted) | [density ]
1.525±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C, protect from light | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
9.43±0.60(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from Salvia miltiorrhiza. | [Uses]
Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to increased inward current during the early phases of the action potential (AP)[1][2]. | [target]
Calcium Channel | Sodium Channel | Potassium Channel | [storage]
-20°C, protect from light | [References]
[1] Fish JM, et al. Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome. Circulation. 2006 Mar 21;113(11):1393-400. DOI:10.1161/CIRCULATIONAHA.105.601690
[2] Yoon JY, et al. A novel Na+ channel agonist, dimethyl lithospermate B, slows Na+ current inactivation and increases action potential duration in isolated rat ventricular myocytes. Br J Pharmacol. 2004 Nov;143(6):765-73. DOI:10.1038/sj.bjp.0705969 |
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