| Identification | Back Directory | [Name]
D-Glucitol, 1,5-dideoxy-1,5-epithio-1-C-[5-[(4-ethoxyphenyl)Methyl]-2-Methoxy-4-Methylphenyl]-, (1S)- | [CAS]
898537-18-3 | [Synonyms]
TS-71
TS 071
(Lusefi)
Luseogliflozin
TS 071; TS071; TS-71
Luseogliflozin USP/EP/BP
(1S)-1,5-Dideoxy-1,5-epithio-1-C-[5-[(4-ethoxyphenyl)methyl]-2-methoxy-4-methylphenyl]-D-glucitol
D-Glucitol, 1,5-dideoxy-1,5-epithio-1-C-[5-[(4-ethoxyphenyl)Methyl]-2-Methoxy-4-Methylphenyl]-, (1S)-
(2S,3R,4R,5S,6R)-2-[5-[(4-ethoxyphenyl)methyl]-2-methoxy-4-methylphenyl]-6-(hydroxymethyl)thiane-3,4,5-triol
D-Glucitol, 1,5-dideoxy-1,5-epithio-1-C-[5-[(4-ethoxyphenyl)Methyl]-2-Methoxy-4-Methylphenyl]-, (1S)- USP/EP/BP
Luseogliflozin,D-Glucitol, 1,5-dideoxy-1,5-epithio-1-C-[5-[(4-ethoxyphenyl)Methyl]-2-Methoxy-4-Methylphenyl]-, (1S)- | [Molecular Formula]
C23H30O6S | [MDL Number]
MFCD18251435 | [MOL File]
898537-18-3.mol | [Molecular Weight]
434.56 |
| Chemical Properties | Back Directory | [Melting point ]
155.0-157.0℃ | [Boiling point ]
624.5±55.0 °C(Predicted) | [density ]
1.278±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.25±0.70(Predicted) | [color ]
White to off-white | [InChIKey]
WHSOLWOTCHFFBK-ZQGJOIPISA-N | [SMILES]
[C@H]1(S[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C1=CC(CC2=CC=C(OCC)C=C2)=C(C)C=C1OC |
| Hazard Information | Back Directory | [Uses]
Luseogliflozin is used n biological studies as a potent and selective renal sodium-glucose cotransporter 2 (SGLT2) inhibitor with anti-hyperglycemic activity. | [Definition]
ChEBI: Luseogliflozin is a diarylmethane. | [in vivo]
Luseogliflozin (10 mg/kg, oral, 7 days) improves hyperglycemia and promotes β-cell proliferation in mice[2]. | Animal Model: | C57BL/6J male mice induced by OSI-906[2] | | Dosage: | 10 mg/kg/daily, 7 days | | Administration: | Oral | | Result: | Inhibited SGLT2 and significantly improved hyperglycemia in mice, but did not improve hyperinsulinemia.Had no effect on hepatic steatosis and adipose tissue atrophy, and improved the quality and proliferation of β cells. |
| [IC 50]
SGLT2: 2.26 nM (IC50); SGLT1: 3990 nM (IC50) |
|
| Company Name: |
Lynnchem
|
| Tel: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
| Company Name: |
Novachemistry
|
| Tel: |
44-20819178-90 02081917890 |
| Website: |
https://www.novachemistry.com/ |
|