| Identification | Back Directory | [Name]
ABT-888 | [CAS]
912445-05-7 | [Synonyms]
ABT-88
ABT-888
Willipani
ABT888 HCl
Veliparib HCl
ABT 888;ABT888
Veliparib 2HCl
ABT888(2HCl salt)
ABT-888 USP/EP/BP
ABT888(Veliparib HCL)
ABT-888 dihydrochloride
Veliparib hydrochloride
Veliparib dihydrochloride
Veliparib dihydrochloride salt
Veliparib dihydrochloride, >=98%
Veliparib (ABT-888 hydrochloride)
ABT-888(Veliparib dihydrochloride)
Veliparib (ABT-888) dihydrochloride
2-[(2S)-2-Methyl-2-pyrrolidinyl]-1H-benziMidazole-4-carboxaMide
ABT 888 dihydrochloride - Veliparib dihydrochloride | A 861695 dihydrochloride
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-7-carboxamide dihydrochloride
2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-4-carboxamide dihydrochloride
2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide,dihydrochloride
(R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide dihydrochloride
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4-
carboxamide,dihydrochloridesalt
1H-Benzimidazole-7-carboxamide, 2-[(2R)-2-methyl-2-pyrrolidinyl]-, hydrochloride (1:2)
(R)-2-(2-Methylpyrrolidin-2-yl)-1H-benimidazole-4-carboxamide dihydrochloride (VELIPARIB) | [EINECS(EC#)]
1592732-453-0 | [Molecular Formula]
C13H16N4O | [MDL Number]
MFCD12407402 | [MOL File]
912445-05-7.mol | [Molecular Weight]
244.296 |
| Chemical Properties | Back Directory | [Melting point ]
>173°C (dec.) | [storage temp. ]
Refrigerator | [solubility ]
Methanol (Slightly, Heated), THF (Slightly, Heated) | [form ]
Colorless to white crystalline solid. | [color ]
Off-White to Dark Yellow |
| Hazard Information | Back Directory | [Uses]
Potent inhibitor of PARP-1 and PARP-2 (potency ≤5nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibition and induction. Shows broad spectrum of chemo- and radiopotentiation. Is toxic to both oxic and hypoxic cells. Enantiomeric purity ≥97% suitable for in vivo studies. Does not show inherent cytotoxicity and shows no single agent activity in tumor models. Has excellent bioavailability and good blood-brain permeation. Increases tumor growth delay resulting from radiation and DNA-damaging agents. | [in vivo]
The oral bioavailability of Veliparib is 56%-92% in mice, SD rats, beagle dogs, and cynomolgus monkeys after oral administration[1]. Veliparib (25 mg/kg, i.p.) can improve tumor growth delay in a NCI-H460 xenograft model. Combination with radiation, veliparib decreases the tumor vessel formation[3]. Veliparib reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg in A375 and Colo829 xenograft models and the suppression can be maintained over time[4]. | [IC 50]
PARP-2: 2.9 nM (Ki); PARP-1: 5.2 nM (Ki) | [storage]
Store at -20°C |
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