| Identification | Back Directory | [Name]
NU1025 | [CAS]
90417-38-2 | [Synonyms]
NU1025
NSC 696807
NU1025
(NSC 696807)
PARP Inhibitor VI, NU1025
8-Hydroxy-2-methylquinazolin-4(3H)
8-HYDROXY-2-METHYLQUINAZOLINE-4-ONE
8-HYDROXY-2-METHYL-4(3H)-QUINAZOLINONE
8-HYDROXY-2-METHYLQUINAZOLIN-4[3H]-ONE
8-hydroxy-2-methyl-1H-quinazolin-4-one
8-hydroxy-2-methylquinazolin-4(1H)-one
4(3H)-Quinazolinone, 8-hydroxy-2-Methyl-
8-Hydroxy-2-methylquinazoline-4-one ,97% | [Molecular Formula]
C9H8N2O2 | [MDL Number]
MFCD00942555 | [MOL File]
90417-38-2.mol | [Molecular Weight]
176.17 |
| Chemical Properties | Back Directory | [Appearance]
Off-White to Pale Yellow Solid | [Melting point ]
253-258°C | [Boiling point ]
345.4±44.0 °C(Predicted) | [density ]
1.42 | [storage temp. ]
−20°C
| [solubility ]
DMSO: 35 mg/mL, soluble
| [form ]
solid
| [pka]
8.68±0.20(Predicted) | [color ]
off-white | [CAS DataBase Reference]
90417-38-2 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White to Pale Yellow Solid | [Uses]
A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively | [Definition]
ChEBI: A member of the class of quinazolines that is quinazolin-4(1H)-one substituted by a hydroxy group at position 8 and a methyl group at position 2. It has been shown to exhibit inhibitory activity against poly(ADP-ribose) polymerase. | [Uses]
NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.[Cayman Chemical] | [Biological Activity]
Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). K i and IC 50 values are 48 and 400 nM respectively. | [Description]
NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM).1 It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs.2,3 NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.4 | [storage]
Store at RT | [References]
[1] ROGER J. GRIFFIN. Resistance-Modifying Agents. 5. 1 Synthesis and Biological Properties of Quinazolinone Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase (PARP)[J]. Journal of Medicinal Chemistry, 1998, 41 26: 5247-5256. DOI: 10.1021/jm980273t
[2] KJ BOWMAN. Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064[J]. British Journal of Cancer, 1998, 78 10: 1269-1277. DOI: 10.1038/bjc.1998.670
[3] C A DELANEY. Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines.[J]. Clinical Cancer Research, 2000, 6 7: 2860-2867.
[4] SLAWOMIR KUMALA. Repair of DNA strand breaks in a minichromosome in vivo: kinetics, modeling, and effects of inhibitors.[J]. PLoS ONE, 2013: e52966. DOI: 10.1371/journal.pone.0052966 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
BioPharmaMatrix,Inc.
|
| Telephone: |
0510-86010668 13395169561; |
| Website: |
http://www.biopharmamatrix.com |
|