| Identification | More | [Name]
4-Nitrobiphenyl | [CAS]
92-93-3 | [Synonyms]
1,1'-BIPHENYL, 4-NITRO-
4-NITRO-1,1'-BIPHENYL
4-NITROBIPHENYL
4-NITROLBIPHENYL
AKOS 223-11
p-Nitrodiphenyl
1-Nitro-4-phenylbenzene
4-nitro-1’-biphenyl
4-nitro-bipheny
4-nitrobiphenyle
4-Nitrodiphenyl
4-Phenylnitrobenzene
4-phenyl-nitrobenzene
Ba 2794
Biphenyl, 4-nitro-
p-Nitrobiphenyl
p-Phenylnitrobenzene
p-phenyl-nitrobenzene
PARA-NITROBIPHENYL
PARA-NITRODIPHENYL | [EINECS(EC#)]
202-204-7 | [Molecular Formula]
C12H9NO2 | [MDL Number]
MFCD00007342 | [Molecular Weight]
199.21 | [MOL File]
92-93-3.mol |
| Chemical Properties | Back Directory | [Appearance]
4-Nitrobiphenyl exists as yellow plates or needles.. | [Melting point ]
114 °C | [Boiling point ]
340 °C | [density ]
1.1919 (rough estimate) | [refractive index ]
1.5880 (estimate) | [Fp ]
43 °C | [solubility ]
Soluble in acetic acid, benzene, chloroform, and ether (Weast, 1986) | [form ]
Solid | [color ]
White | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
insoluble | [Henry's Law Constant]
2.8×100 mol/(m3Pa) at 25℃, HSDB (2015) | [Exposure limits]
OSHA PEL-TWA: Ca | [InChI]
InChI=1S/C12H9NO2/c14-13(15)12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H | [InChIKey]
BAJQRLZAPXASRD-UHFFFAOYSA-N | [SMILES]
C1(C2=CC=CC=C2)=CC=C([N+]([O-])=O)C=C1 | [CAS DataBase Reference]
92-93-3(CAS DataBase Reference) | [IARC]
3 (Vol. 4, Sup 7) 1987 | [NIST Chemistry Reference]
1,1'-Biphenyl, 4-nitro-(92-93-3) | [EPA Substance Registry System]
92-93-3(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS08,GHS09 | [Signal word ]
Danger | [Hazard statements ]
H350-H411 | [Precautionary statements ]
P202-P308+P313 | [Hazard Codes ]
T,N | [Risk Statements ]
R45:May cause cancer.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
2811 | [RTECS ]
DV5600000 | [TSCA ]
TSCA listed | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29042090 | [Safety Profile]
Confirmed carcinogen
with experimental carcinogenic,
neoplastigenic, and tumorigenic data. Poison
by intraperitoneal route. Moderately toxic by
ingestion. Mutation data reported. When
heated to decomposition it emits toxic
fumes of NOx. See also NITRO
COMPOUNDS OF AROMATIC
HYDROCARBONS. | [Hazardous Substances Data]
92-93-3(Hazardous Substances Data) | [Toxicity]
Acute oral LD50 for rats 2,230 mg/kg, rabbits 1,970 mg/kg (quoted, RTECS, 1985). |
| Hazard Information | Back Directory | [General Description]
White to yellow needle-like crystalline solid with a sweetish odor. | [Reactivity Profile]
4-NITROBIPHENYL(92-93-3) is incompatible with the following: Strong reducers . | [Air & Water Reactions]
Insoluble in water. | [Hazard]
Toxic by ingestion and skin contact. Confirmed carcinogen. | [Potential Exposure]
4-Nitrobiphenyl was formerly used in
the synthesis of 4-aminodiphenyl. It is presently used only
for research purposes; there are no commercial uses. | [First aid]
Move victim to fresh air. Call 911 or emergency
medical service. Give artificial respiration if victim is not
breathing. Do not use mouth-to-mouth method if victim
ingested or inhaled the substance; give artificial respiration
with the aid of a pocket mask equipped with a one-way valve
or other proper respiratory medical device. Administer oxygen
if breathing is difficult. Remove and isolate contaminated
clothing and shoes. In case of contact with substance, immediately
flush skin or eyes with running water for at least
20 minutes. For minor skin contact, avoid spreading material
on unaffected skin. Keep victim warm and quiet. Effects of
exposure (inhalation, ingestion or skin contact) to substance
may be delayed. Ensure that medical personnel are aware of
the material(s) involved and take precautions to protect themselves.
Medical observation is recommended for 24 48 hours
after breathing overexposure, as pulmonary edema may be
delayed. As first aid for pulmonary edema, a doctor or authorized
paramedic may consider administering a drug or other
inhalation therapy. | [Shipping]
UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required. | [Incompatibilities]
Incompatible with strong reducing agents
such as hydrides, oxidizers (chlorates, nitrates, peroxides,
permanganates, perchlorates, chlorine, bromine, fluorine,
etc.); contact may cause fires or explosions. Keep away
from alkaline materials, strong bases, strong acids, oxoacids,
epoxides. | [Chemical Properties]
4-Nitrobiphenyl exists as yellow plates or needles.. | [Chemical Properties]
Yellow Solid | [Waste Disposal]
Incineration @ 982℃/2.0 seconds
(minimum) with scrubbing for nitrogen oxides
abatement. | [Uses]
4-Nitrobiphenyl has some uses as a plasticizer, fungicide, and
wood preservative. | [Uses]
Formerly in preparation of p-biphenylamine, q.v. | [Uses]
Formerly used as an intermediate for
4-aminobiphenyl | [Definition]
ChEBI: 4-Nitrobiphenyl is a member of biphenyls. | [Synthesis Reference(s)]
Tetrahedron Letters, 37, p. 4499, 1996 DOI: 10.1016/0040-4039(96)00924-0 | [Health Hazard]
p-Nitrobiphenyl (PNB) is a
urinary bladder carcinogen in dogs. | [Toxicology]
4-Nitrobiphenyl is no longer manufactured or used in the United States. Limited information is available on the health effects of 4-nitrobiphenyl. Acute (short-term) exposure to 4-nitrobiphenyl in humans results in irritation of the eyes, mucous membranes, and respiratory tract, such as headache, nausea, vomiting, and fatigue. Chronic (long-term) exposure to high concentrations of 4-nitrobiphenyl in workers has resulted in effects on the peripheral and central nervous systems as well as the liver and kidney. No information on the reproductive, developmental, or carcinogenic effects of 4-nitrobiphenyl in humans is available. EPA has not classified 4-nitrobiphenyl for carcinogenicity. 4-Nitrobiphenyl is no longer manufactured, imported, used, or sold in the United States.
| [Carcinogenicity]
The case for the carcinogenicity of PNB
is supported by (1) the induction of urinary
bladder cancer in dogs after administration of
PNB; (2) the evidence that PNB is metabolized
in vivo to 4-aminobiphenyl (a potent carcinogen);
and (3) the possibility that the cases of
human urinary bladder cancer attributed to 4-
aminobiphenyl may also have been induced by
exposure to PNB.1 |
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