| Identification | More | [Name]
2-Picoline-N-oxide | [CAS]
931-19-1 | [Synonyms]
2-METHYLPYRIDINE 1-OXIDE
2-METHYLPYRIDINE N-OXIDE
2-PICOLINE-N-OXIDE
ALPHA-PICOLINE N-OXIDE
N-OXIDE OF 2-METHYL PYRIDINE
2-methyl-pyridin1-oxide
2-Picoline, 1-oxide
2-picoline-oxide
alpha-Picoline 1-oxide
-Picoline N-oxide
Pyridine,2-methyl-,1-oxide
2-PICOLINE N-OXIDE, 96+%
Alfa picoline oxide
2-PICOLINE-N-OXIDE 95%(MIN)
2-Methylpyridine-N-oxide hemihydrate(2-Picoline-N-oxide hemihydrate)
Alpha-picoline N-oxide, 2-Picoline N-oxide
2-Methyl-1-oxidopyridin-1-ium
a-Picoline 1-oxide
a-Picoline N-oxide
1-Oxylato-2-methylpyridinium | [EINECS(EC#)]
213-230-3 | [Molecular Formula]
C6H7NO | [MDL Number]
MFCD00006199 | [Molecular Weight]
109.13 | [MOL File]
931-19-1.mol |
| Chemical Properties | Back Directory | [Appearance]
light yellow to brown crystalline low melting mass | [Melting point ]
41-45 °C(lit.)
| [Boiling point ]
259-261 °C
| [density ]
1.1143 (rough estimate) | [refractive index ]
1.5444 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
RT, stored under nitrogen | [form ]
powder to lump to clear liquid | [pka]
pK1:1.029(+1) (25°C) | [color ]
White or Colorless to Light yellow | [Water Solubility ]
soluble | [Sensitive ]
Hygroscopic | [BRN ]
106916 | [InChI]
InChI=1S/C6H7NO/c1-6-4-2-3-5-7(6)8/h2-5H,1H3 | [InChIKey]
CFZKDDTWZYUZKS-UHFFFAOYSA-N | [SMILES]
C1(C)[N+]([O-])=CC=CC=1 | [CAS DataBase Reference]
931-19-1(CAS DataBase Reference) | [NIST Chemistry Reference]
Pyridine, 2-methyl-, 1-oxide(931-19-1) | [EPA Substance Registry System]
931-19-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn,F | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R10:Flammable. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes .
S16:Keep away from sources of ignition-No smoking . | [WGK Germany ]
3
| [F ]
3 | [TSCA ]
Yes | [HS Code ]
29333990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
light yellow to brown crystalline low melting mass | [Uses]
2-Picoline N-oxide is used in proteomics research. Also used as pharmaceutical intermediates. | [Application]
2-Methylpyridine 1-oxide is a useful building block for organic synthesis. | [Definition]
ChEBI: Picoline N-oxide is a member of methylpyridines and a member of pyridine N-oxides. | [Synthesis]
K2CO3 (20 mmol) and urea peroxide (10 mmol) were dissolved in dry 1,4-dioxane (100 mL), which was then stirred and reacted at room temperature for 1 hour. Trifluoroacetic anhydride (10 mmol) was added dropwise to the mixture below 12 °C to bring the mixtu | [Purification Methods]
Purify the N-oxide by fractional distillation, and it can be recrystallised from *C6H6/hexane but is hygroscopic. [Bullitt & Maynard J Am Chem Soc 76 1370 1954, Ross et al. J Am Chem Soc 78 3625 1956, IR: Wiley & SlaymAker J Am Chem Soc 79 2233 1957.] The picrate has m 125-126.5o (from EtOH) [Boekelheide & Linn J Am Chem Soc 76 1286 1954]. The phthalate has m 115-116o (from EtOH) [den Hertog et al. Recl Trav Chim Pays-Bas 70 591 1951.]. [Beilstein 20 III/IV 2689, 20/5 V 479.] |
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