| Identification | More | [Name]
4-Phenylpyridine | [CAS]
939-23-1 | [Synonyms]
4-AZABIPHENYL
4-PHENYLPYRIDINE
4-PYRIDYLBENZENE
TIMTEC-BB SBB008518
4-Aza-1,1'-biphenyl
4-phenyl-pyridin
p-Phenylpyridine
Pyridine, 4-phenyl-
4-PHENYLPYRIDINE APPROX. 90%
4-Phenylpyridine,99% | [EINECS(EC#)]
213-357-4 | [Molecular Formula]
C11H9N | [MDL Number]
MFCD00006420 | [Molecular Weight]
155.2 | [MOL File]
939-23-1.mol |
| Chemical Properties | Back Directory | [Appearance]
LIGHT YELLOW TO BEIGE CRYSTALLINE POWDER | [Melting point ]
69-73 °C (lit.) | [Boiling point ]
274-275 °C (lit.) | [density ]
1.1088 (rough estimate) | [refractive index ]
1.6210 (estimate) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform, Methanol | [form ]
Crystalline Powder | [pka]
5.45±0.10(Predicted) | [color ]
Light yellow to beige | [Water Solubility ]
SOLUBLE | [BRN ]
110490 | [InChI]
1S/C11H9N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-9H | [InChIKey]
JVZRCNQLWOELDU-UHFFFAOYSA-N | [SMILES]
c1ccc(cc1)-c2ccncc2 | [LogP]
2.590 | [CAS DataBase Reference]
939-23-1(CAS DataBase Reference) | [NIST Chemistry Reference]
4-phenyl-pyridine(939-23-1) | [EPA Substance Registry System]
939-23-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
UT7141000
| [F ]
10 | [TSCA ]
TSCA listed | [HazardClass ]
IRRITANT, KEEP COLD | [HS Code ]
29333990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
LIGHT YELLOW TO BEIGE CRYSTALLINE POWDER | [Uses]
4-Phenylpyridine is a useful synthetic intermediate. 4-Phenylpyridine has been shown to induce inhibition of mitochondrial respiration in mice. | [Definition]
ChEBI: 4-Phenylpyridine is a phenylpyridine. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 78, p. 1702, 1956 DOI: 10.1021/ja01589a060
Synthetic Communications, 21, p. 619, 1991 DOI: 10.1080/00397919108020828
Tetrahedron Letters, 36, p. 5247, 1995 DOI: 10.1016/0040-4039(95)00983-J | [Enzyme inhibitor]
?This substituted pyridine (FW = 155.20 g/mol; CAS 939-23-1; M.P. = 69- 73°C; B.P. = 274-275°C), which occurs naturally and is likewise a manmade pollutant, inhibits human placental aromatase, Ki = 0.36 μM, monoamine oxidase, and NADH dehydrogenase. 4-Phenylpyridine is also an effective inhibitor of mitochondrial complex I. Note that it both occurs naturally and is an environmental pollutant. |
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