| Identification | More | [Name]
N-Cyanoethyl-N-methylaniline | [CAS]
94-34-8 | [Synonyms]
3-(METHYLPHENYLAMINO)PROPIONITRILE
3-(N-METHYLANILINO)PROPIONITRILE
3-(N-methylanilino)propiononitrile
3-(N-METHYL-N-PHENYLAMINO)PROPIONITRILE
N-(2-CYANOETHYL)-N-METHYLANILINE
N-(B-CYANOETHYL)-N-METHYLANILINE
N-CYANOETHYL-N-METHYL ANILINE
N-METHYL-N-(2-CYANOETHYL)ANILINE
N-METHYL-N-(B-CYANOETHYL)ANILINE
3-(methylphenylamino)-propanenitril
N-Methyl-N-Cyanoethyl Aniline
3-(methyl(phenyl)amino)propanenitrile
3-(METHYLPHENYLAMINO)PROPIONITRILE 97%
N-(2-CYANOETHYL)-N-METHYLANILINE/3-(METHYLPHENYLAMINO)PROPIONITRILE
3-(N-Methyl-N-phenylamino)propiononitrile | [EINECS(EC#)]
202-325-5 | [Molecular Formula]
C10H12N2 | [MDL Number]
MFCD00019856 | [Molecular Weight]
160.22 | [MOL File]
94-34-8.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [TSCA ]
Yes | [PackingGroup ]
III | [HS Code ]
29214300 |
| Hazard Information | Back Directory | [Synthesis]
An activated carbon-supported platinum catalyst (Pt / C, 0.06 mg platinum, 0.0003 mmol, 0.1 mol percent) was added to a 10 mL Schlenk tube; after the evacuation of argon, add 1 mL of solvent (toluene). Under argon protection, to the above system, Were successively added phenylsilane (78.9 mg, 0.75 mmol), 3-Anilinopropionitrile (43.9 mg, 0.3 mmol) and formic acid (27.6 mg, 0.6 mmol). The whole anti-reaction was carried out at 80 ° C with stirring for 15 hours. After completion of the reaction, 3 mL of ethyl acetate was added to the system. The reaction was quenched with aqueous sodium hydroxide (3 mol / L, 3 mL). Ethyl acetate (3 x 10 mL), the organic phase was separated, Dried over anhydrous Na2SO4, and filtered; the solvent was removed by rotary evaporation. The residue was purified by column chromatography on ethyl acetate/petroleum ether = 1: 50 mixed solvent. Separation and purification gave N-(2-Cyanoethyl)-N-methyl aniline 226.4 mg, yield of 55 per cent. | [References]
[1] Journal of Organic Chemistry, 2015, vol. 80, # 20, p. 10375 - 10379
[2] Tetrahedron, 2013, vol. 69, # 6, p. 1712 - 1716
[3] Green Chemistry, 2010, vol. 12, # 5, p. 786 - 789
[4] Synthesis, 2008, # 24, p. 3931 - 3936
[5] Journal of the American Chemical Society, 1944, vol. 66, p. 725,728 |
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